Dimethoxy-phenyl-pyrazino-indol-cpd5i
inhibition of A40 and A42 aggregation (85% and 90% inhibition at 25 M), inhibition of human cholinesterase enzymes (hAChE IC50 = 7.5 microM; hBuChE IC50 15 microM) and antioxidant property (39% inhibition at 25 M)
General
Type : Multitarget,Indole
Chemical_Nomenclature : 3-(3,4-dimethoxyphenyl)pyrazino[1,2-a]indol-1(2H)-one
Canonical SMILES : C1=CC=C2C(=C1)C=C3[N]2CC(NC3=O)C4=CC=C(C(=C4)OC)OC
InChI : InChI=1S\/C19H18N2O3\/c1-23-17-8-7-12(10-18(17)24-2)14-11-21-15-6-4-3-5-13(15)9-16(21)19(22)20-14\/h3-10,14H,11H2,1-2H3,(H,20,22)
InChIKey : HPCDIAFBFSKSJM-UHFFFAOYSA-N
Other name(s) : Compound 5i
MW : 322.36
Formula : C19H18N2O3
CAS_number :
PubChem :
UniChem : HPCDIAFBFSKSJM-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (1)
| Title : Design, synthesis and structure-activity relationship studies of 3-phenylpyrazino[1,2-a]indol-1(2H)-ones as amyloid aggregation and cholinesterase inhibitors with antioxidant activity - Gujral_2022_Eur.J.Med.Chem.Rep_6_100075 |
| Author(s) : Gujral SS , Shakeri A , Hejazi L , Rao PP |
| Ref : Eur J Med Chem Rep , 6 :100075 , 2022 |
| Abstract : Gujral_2022_Eur.J.Med.Chem.Rep_6_100075 |
| ESTHER : Gujral_2022_Eur.J.Med.Chem.Rep_6_100075 |
| PubMedSearch : Gujral_2022_Eur.J.Med.Chem.Rep_6_100075 |
| PubMedID: |