KBR-2822
KBR-2822 promotes OPIDP initiated by either DBDCVP or DFP by affecting a target other than NTE catalytic site
General
Type : Sulfur Compound,Organophosphate,Trifluo,Not A\/B H target
Chemical_Nomenclature : 2-chloro-3-[ethoxy(propylsulfanyl)phosphoryl]oxy-1,1,2-trifluorocyclobutane
Canonical SMILES : CCCSP(=O)(OCC)OC1CC(C1(F)Cl)(F)F
InChI : InChI=1S\/C9H15ClF3O3PS\/c1-3-5-18-17(14,15-4-2)16-7-6-8(11,12)9(7,10)13\/h7H,3-6H2,1-2H3
InChIKey : DEMICWQHGWSYPB-UHFFFAOYSA-N
Other name(s) : phosphorothioic acid-O-(2-chloro-2,3,3-trifluorocyclobutyl)-O-ethyl S-propyl ester,KBR 2822,O-(2-Chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate,Phosphorothioic acid, O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester
MW : 326.70
Formula : C9H15ClF3O3PS
CAS_number : 126988-60-1
PubChem : 182779
UniChem : DEMICWQHGWSYPB-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families :
Stucture :
Protein :
References (3)
| Title : Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors - Lotti_2002_Toxicology_181-182_245 |
| Author(s) : Lotti M |
| Ref : Toxicology , 181-182 :245 , 2002 |
| Abstract : Lotti_2002_Toxicology_181-182_245 |
| ESTHER : Lotti_2002_Toxicology_181-182_245 |
| PubMedSearch : Lotti_2002_Toxicology_181-182_245 |
| PubMedID: 12505319 |
| Title : Repeated low doses of O-(2-chloro-2,3,3 trifluorocyclobutyl) O-ethyl S- propyl phosphorothioate (KBR-2822) do not cause neuropathy in hens - Jokanovic_1998_Arch.Toxicol_72_93 |
| Author(s) : Jokanovic M , Moretto A , Lotti M |
| Ref : Archives of Toxicology , 72 :93 , 1998 |
| Abstract : Jokanovic_1998_Arch.Toxicol_72_93 |
| ESTHER : Jokanovic_1998_Arch.Toxicol_72_93 |
| PubMedSearch : Jokanovic_1998_Arch.Toxicol_72_93 |
| PubMedID: 9456080 |
| Title : The phosphorothioic acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester exacerbates organophosphate polyneuropathy without inhibition of neuropathy target esterase - Moretto_1994_Toxicol.Appl.Pharmacol_129_133 |
| Author(s) : Moretto A , Bertolazzi M , Lotti M |
| Ref : Toxicol Appl Pharmacol , 129 :133 , 1994 |
| Abstract : Moretto_1994_Toxicol.Appl.Pharmacol_129_133 |
| ESTHER : Moretto_1994_Toxicol.Appl.Pharmacol_129_133 |
| PubMedSearch : Moretto_1994_Toxicol.Appl.Pharmacol_129_133 |
| PubMedID: 7974486 |