Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k
IC50 0.027 +/- 0.008 microM (AChE), 0.043 +/- 0.004 microM (BChE), 0.353 +/- 0.01 microM (MAO-A), and 0.716 +/- 0.02 microM (MAO-B)
General
Type : Monoamine-oxidase-inhibitor,Multitarget,Urea derivative,Benzothiazol,Sulfur Compound,Sulfonamide
Chemical_Nomenclature :
Canonical SMILES : CCCCCCCCOC(C1=CC3=C(C=C1)N=C(N([H])C(N([S](C2=CC=C(C)C=C2)(=O)=O)[H])=S)S3)=O
InChI : InChI=1S\/C24H29N3O4S3\/c1-3-4-5-6-7-8-15-31-22(28)18-11-14-20-21(16-18)33-24(25-20)26-23(32)27-34(29,30)19-12-9-17(2)10-13-19\/h9-14,16H,3-8,15H2,1-2H3,(H2,25,26,27,32)
InChIKey : VOKKZFWLZWJWHW-UHFFFAOYSA-N
Other name(s) : Compound 6K
MW : 519.69
Formula : C24H29N3O4S3
CAS_number :
PubChem :
UniChem : VOKKZFWLZWJWHW-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k ligand of proteins in family: BCHE || ACHE
Stucture :
Protein : human-BCHE || human-ACHE
References (1)
| Title : Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase\/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study - Dinh Thanh_2024_Arch.Pharm.(Weinheim)__e2300557 |
| Author(s) : Dinh Thanh N , Son Hai D , Ngoc Toan V , Thi Kim Van H , Thi Kim Giang N , Minh Tri N |
| Ref : Arch Pharm (Weinheim) , :e2300557 , 2024 |
| Abstract : Dinh Thanh_2024_Arch.Pharm.(Weinheim)__e2300557 |
| ESTHER : Dinh Thanh_2024_Arch.Pharm.(Weinheim)__e2300557 |
| PubMedSearch : Dinh Thanh_2024_Arch.Pharm.(Weinheim)__e2300557 |
| PubMedID: 38321839 |