F329Q_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : OP-resistance resistant to echothiophate decreases IC50 of smaller than (iso-OMPA) OP DFP Gnatt_1994_J.Neurochem_62_749

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 331

Kinetic Parameter : Butyrylthiocholine_F329Q_human-BCHE, Echothiophate_F329Q_human-BCHE, Iso-OMPA_F329Q_human-BCHE, DFP_F329Q_human-BCHE

News : No news

Comment :
p.F329Q Phe329Gln (p.F357Q Phe357Gln in primary sequence with 28 amino-acids signal peptide) resistant to echothiophate

References (1)

Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749
Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H
Ref : Journal of Neurochemistry , 62 :749 , 1994
Abstract :
PubMedSearch : Gnatt_1994_J.Neurochem_62_749
PubMedID: 8294937