human-BCHE

Homo sapiens (Human) butyrylcholinesterase

Comment

Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase. Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics.Various autosomal recessive mutations of the gene exist in human population || Another short contig contains a little bit of the gene AC069210.7.15194.32648 || Cterminus T peptide

Relationship

Family : BCHE

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

6EMI - Crystal structure of a variant of human butyrylcholinesterase expressed in bacteria 2Y1K - Structure of Human Butyrylcholinesterase Inhibited by CBDP (12h soak) : Phosphoserine Adduct 8CGO - Structure of human butyrylcholinesterase in complex with N-{[2-(benzyloxy)-3-methoxyphenyl]methyl}-N-[3-(2-fluorophenyl)propyl]cyclobutanamine 8AI7 - Human butyrylcholinesterase in complex with Cpd-6-8AI7 8AM1 - Human butyrylcholinesterase in complex with zinc and N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium 8AM2 - Human butyrylcholinesterase in complex with 2,2'-(((1E,1'E)-(2-phenylpyrimidine-4,6-diyl)bis(methaneylylidene))bis(hydrazin-1-yl-2-ylidene))bis(N,N,N-trimethyl-2-oxoethan-1-aminium) 7ZPB - Structure of hemiacetylated human butyrylcholinesterase upon reaction with 8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinoline-2-carbaldehyde 7QHD - Human Butyrylcholinesterase in complex with (S)-1-(4-((2-(1H-indol-3-yl)ethyl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide, compound 39 7QHE - Human Butyrylcholinesterase in complex with (S)-1-(4-((naphthalen-1-yl)carbamoyl)benzyl)-N-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperidine-3-carboxamide, compound 43 7QBQ - Human butyrylcholinesterase in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide 7QBR - Human butyrylcholinesterase in complex with (Z)-N-tert-butyl-1-(8-(3-(4-(prop-2-yn-1-yl)piperazin-1-yl)propoxy)quinolin-2-yl)methanimine oxide 7Q1M - Crystal structure of human butyrylcholinesterase in complex with N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide 7Q1N - Crystal structure of human butyrylcholinesterase in complex with N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-2,2-diphenylacetamide 7Q1O - Crystal structure of human butyrylcholinesterase in complex with N-[(2S)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide 7Q1P - Crystal structure of human butyrylcholinesterase in complex with N-[(2R)-3-[(cyclohexylmethyl)amino]-2-hydroxypropyl]-3,3-diphenylpropanamide 7AWI - Crystal structure of human butyrylcholinesterase in complex with compound 70 tert-butyl 3-(((2-((1-benzyl-1H-indol-4-yl)oxy)ethyl)amino)methyl]piperidine-1-carboxylate 7AWH - Crystal structure of human butyrylcholinesterase in complex with compound 54 tert-butyl 3-(((2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)amino)methyl)piperidine-1-carboxylate 7AWG - Crystal structure of human butyrylcholinesterase in complex with compound 27 (2-((1-(benzenesulfonyl)-1H-indol-4-yl)oxy)ethyl)(benzyl)amine 7P86 - WITHDRAWN Crystal structure of human butyrylcholinesterase inibited by omethoate 7P89 - WITHDRAWN Crystal structure of human butyrylcholinesterase inibited by chlorpyrifos oxon 7AMZ - Human butyrylcholinesterase in complexe with N-((2S,3R)-3-hydr oxy-4-(neopentylamino)-1-phenylbutan-2-yl)-2,2-diphenylacetamide (51) 7BO4 - Human Butyrylcholinesterase in complex with 3-(2-(butyl(2-cycloheptylethyl)amino)ethyl)-1H-indol-6-ol 7BO3 - Human Butyrylcholinesterase in complex with N-(2-(1H-Indol-3-yl)ethyl)-2-cycloheptyl-N-methylethan-1-amine 7BGC - Human Butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor 6T9P - Structure of human butyrylcholinesterase in complex with R enantiomer of oxime III, methylimidazole derivative of 2-hydroxyimino-N-(azidophenylpropyl)acetamide 6T9S - Structure of human butyrylcholinesterase in complex with S enantiomer of oxime III, methylimidazole derivative of 2-hydroxyimino-N-(azidophenylpropyl)acetamide 6SAM - Structure of human butyrylcholinesterase in complex with 1-(2,3-dihydro-1H-inden2-yl)piperidin-3-yl N-phenyl carbamate 6RUA - Structure of recombinant human butyrylcholinesterase in complex with a coumarin-based fluorescent probe linked to sulfonamide type inhibitor 6R6W - Structure of recombinant human butyrylcholinesterase in complex with a fluorescent NBD-based probe 6R6V - Structure of recombinant human butyrylcholinesterase in complex with a fluorescent coumarin-based probe 6QAA - Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(2-cycloheptylethyl)-3-(1H-indol-3-yl)propanamide 6QAB - Human Butyrylcholinesterase in complex with (S)-N-(1-((2-cycloheptylethyl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-N,N-dimethylbutan-1-aminium 6QAC - Human Butyrylcholinesterase in complex with (S)-2-(butylamino)-N-(3-cycloheptylpropyl)-3-(1H-indol-3-yl)propanamide 6QAD - Human Butyrylcholinesterase in complex with ((S)-2-(butylamino)-N-(2-(4-(dimethylamino)cyclohexyl)ethyl)-3-(1H-indol-3-yl)propanamide 6XTA - Human Butyrylcholinesterase in complex with compound 18 6QAE - Human Butyrylcholinesterase in complex with (S)-N2-butyl-N1-(2-cycloheptylethyl)-3-(1H-indol-3-yl)-N1,N2-dimethylpropane-1,2-diamine 6I2T - Model of full-length, fully-glycosylated human butyrylcholinesterase tetramer 6I0B - Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor 6I0C - Human butyrylcholinesterase in complex with the S enantiomer of a chlorotacrine-tryptophan multi-target inhibitor 6EZ2 - Human butyrylcholinesterase carbamylated. supersedes 6EUK 6EYF - Butyrylcholinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue (replaced 6EUL) 5NN0 - Human butyrylcholinesterase in complex with inhibitor with picomolar activity 6ESY - Human butyrylcholinesterase in complex with thioflavine T 6ESJ - Human butyrylcholinesterase in complex with propidium 6EQP - Human butyrylcholinesterase in complex with ethopropazine 6EQQ - Human butyrylcholinesterase in complex with huprine 19 6EP4 - Human butyrylcholinesterase in complex with decamethonium 6F7Q - Human Butyrylcholinesterase complexed with N-Propargyliperidines 5LKR - Human Butyrylcholinesterase complexed with N-Propargyliperidine 5LKR-6yc 5K5E - Discovery and structure-activity relationships of a highly selective Butyrylcholinesterase inhibitor by structure-based virtual screening (5JYW withdrawn) 5DYT - Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-methylnaphthalene-2-sulfonamide 5DYW - Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide 5DYY - Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamide 4XII - X-ray structure of human butyrylcholinesterase complex with 3-pyridin-4-yl-2,4-dihydro-indeno[1,2-.C.]pyrazole 6ZWI - Human butyrylcholinesterase in complex with ((6-((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamido)hexyl)triphenylphosphonium bromide) 4TPK - Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide 4BDS - Human butyrylcholinesterase in complex with tacrine 4BBZ - Structure of human butyrylcholinesterase inhibited by CBDP (2-min soak): Cresyl-phosphoserine adduct 4B0O - Crystal structure of soman-aged human butyrylcholinesterase in complex with benzyl pyridinium-4-methyltrichloroacetimidate 4B0P - Crystal structure of soman-aged human butyrylcholinesterase in complex with methyl 2-(pentafluorobenzyloxyimino)pyridinium 4AXB - Crystal structure of soman-aged human butyrylcholinesterase in complex with 2-PAM 4AQD - Crystal structure of fully glycosylated human butyrylcholinesterase 7AIY - Crystal structure of human butyrylcholinesterase in complex with 2-{1-[4-(12-Amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolin-9-yl)butyl]-1H-1,2,3-triazol-4-yl}-N-[4-hydroxy-3-methoxybenzyl]acetamide compound 5i 2XQF - X-ray Structure of human butyrylcholinesterase inhibited by racemic VX 2XQG - X-ray Structure of human butyrylcholinesterase inhibited by racemic VR 2XQJ - X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(R) 2XQK - X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S) 2XQI - X-ray Structure of human butyrylcholinesterase inhibited by racemic CVX 3O9M - Co-crystallization studies of full length recombinant BChE with cocaine offers insights into cocaine detoxification 2XMB - G117H mutant of human butyrylcholinesterase in complex with sulfate 2XMC - G117H mutant of human butyrylcholinesterase in complex with fluoride anion 2XMD - G117H mutant of human butyrylcholinesterase in complex with echothiophate 2XMG - G117H mutant of human butyrylcholinesterase in complex with VX 2WID - Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA1 2WIF - Aged form of human butyrylcholinesterase inhibited by tabun analogue TA1 2WIG - Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA4 2WIJ - Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA5 2WIK - Non aged form of human butyrylcholinesterase inhibited by tabun analogue TA6 2WIL - Aged form of human butyrylcholinesterase inhibited by tabun analogue TA5 2WSL - Aged form of human butyrylcholinesterase inhibited by tabun analogue TA4 3DJY - Nonaged Form of Human Butyrylcholinesterase Inhibited by Tabun 3DKK - Aged Form of Human Butyrylcholinesterase Inhibited by Tabun 2PM8 - Crystal structure of recombinant full length human butyrylcholinesterase 2J4C - Structure of human Butyrylcholinesterase in complex with 10mM HgCl2 1P0I - Crystal structure of human butyrylcholinesterase 1P0M - Crystal structure of human butyrylcholinesterase in complexe with a choline molecule 1P0P - Crystal structure of soman-aged human butyrylcholinesterase in complex with the substrate analog butyrylthiocholine 1P0Q - Crystal structure of soman-aged human butyrylcholinesterase 1XLU - X-Ray Structure Of Aged Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Bound To Butyrylcholinesterase 1XLV - Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate. 1XLW - Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate

Acetylcholine_WT_human-BCHE Acetylcholine_D70G_human-BCHE Propionylcholine_WT_human-BCHE Propionylcholine_D70G_human-BCHE Butyrylcholine_WT_human-BCHE Butyrylcholine_D70G_human-BCHE Pentanoylcholine_WT_human-BCHE Pentanoylcholine_D70G_human-BCHE Hexanoylcholine_WT_human-BCHE Hexanoylcholine_D70G_human-BCHE Heptanoylcholine_WT_human-BCHE Heptanoylcholine_D70G_human-BCHE Benzoylcholine_WT_human-BCHE Benzoylcholine_D70G_human-BCHE Succinyldithiocholine_WT_human-BCHE Succinyldithiocholine_D70G_human-BCHE Heroin_WT_human-BCHE Heroin_D70G_human-BCHE Procaine_WT_human-BCHE Procaine_D70G_human-BCHE Tetracaine_WT_human-BCHE Tetracaine_D70G_human-BCHE O-Nitrophenylbutyrate_WT_human-BCHE O-Nitrophenylbutyrate_D70G_human-BCHE 1-Naphtylacetate_WT_human-BCHE 1-Naphtylacetate_D70G_human-BCHE Methylprednisolone-acetate_WT_human-BCHE Methylprednisolone-acetate_D70G_human-BCHE Aspirin_WT_human-BCHE Aspirin_D70G_human-BCHE Choline_WT_human-BCHE Choline_D70G_human-BCHE Tetramethylammonium_WT_human-BCHE Tetramethylammonium_D70G_human-BCHE Meperidine_WT_human-BCHE Meperidine_D70G_human-BCHE Succinylcholine~Suxamethonium_WT_human-BCHE Succinylcholine~Suxamethonium_D70G_human-BCHE Decamethonium_WT_human-BCHE Decamethonium_D70G_human-BCHE Chlorpromazine_WT_human-BCHE Chlorpromazine_D70G_human-BCHE Dibucaine_WT_human-BCHE Dibucaine_D70G_human-BCHE Win5303_WT_human-BCHE Win5303_D70G_human-BCHE Win4510_WT_human-BCHE Win4510_human-BCHE Vecuronium_WT_human-BCHE Vecuronium_D70G_human-BCHE Pancuronium_WT_human-BCHE Pancuronium_D70G_human-BCHE 17-desoxypancuronium_WT_human-BCHE 17-desoxypancuronium_D70G_human-BCHE Neostigmine~Prostigmine_WT_human-BCHE Neostigmine~Prostigmine_D70G_human-BCHE Dibutyrate-pancuronium_WT_human-BCHE Dibutyrate-pancuronium_D70G_human-BCHE Physostigmine~Eserine_WT_human-BCHE Physostigmine~Eserine_D70G_human-BCHE Ro-2-0683_WT_human-BCHE Ro-2-0683_D70G_human-BCHE Bambuterol_WT_human-BCHE Paraoxon_G117H_human-BCHE Butyrylthiocholine_WT_human-BCHE Butyrylthiocholine_F525X_human-BCHE Benzoylcholine_F525X_human-BCHE O-Nitrophenylbutyrate_F525X_human-BCHE Butyrylthiocholine_L286K_human-BCHE Butyrylthiocholine_L286Q_human-BCHE Butyrylthiocholine_L286R_human-BCHE Butyrylthiocholine_L286D_human-BCHE Butyrylthiocholine_F329Q_human-BCHE Butyrylthiocholine_F329L_human-BCHE Butyrylthiocholine_F329C_human-BCHE Butyrylthiocholine_F329D_human-BCHE Butyrylthiocholine_Y440D_human-BCHE Echothiophate_WT_human-BCHE Echothiophate_L286K_human-BCHE Echothiophate_L286Q_human-BCHE Echothiophate_L286D_human-BCHE Echothiophate_F329Q_human-BCHE Echothiophate_F329L_human-BCHE Echothiophate_F329C_human-BCHE Echothiophate_F329D_human-BCHE Echothiophate_Y440D_human-BCHE Iso-OMPA_WT_human-BCHE Iso-OMPA_L286K_human-BCHE Iso-OMPA_L286Q_human-BCHE Iso-OMPA_L286D_human-BCHE Iso-OMPA_F329Q_human-BCHE Iso-OMPA_F329L_human-BCHE Iso-OMPA_F329C_human-BCHE Iso-OMPA_F329D_human-BCHE Iso-OMPA_Y440D_human-BCHE DFP_WT_human-BCHE DFP_L286Q_human-BCHE DFP_L286D_human-BCHE DFP_F329Q_human-BCHE DFP_F329L_human-BCHE DFP_F329C_human-BCHE DFP_F329D_human-BCHE DFP_Y440D_human-BCHE Butyrylthiocholine_D70G_human-BCHE Butyrylthiocholine_G115A_human-BCHE Butyrylthiocholine_G115S_human-BCHE Butyrylthiocholine_G115C_human-BCHE Butyrylthiocholine_G115D_human-BCHE Butyrylthiocholine_G115E_human-BCHE Butyrylthiocholine_G116E_human-BCHE Butyrylthiocholine_G117E_human-BCHE Butyrylthiocholine_G117D_human-BCHE Butyrylthiocholine_G116A\/G117D_human-BCHE Butyrylthiocholine_N68D_human-BCHE Butyrylthiocholine_N68K_human-BCHE Butyrylthiocholine_N68R_human-BCHE Butyrylthiocholine_N68Y_human-BCHE Butyrylthiocholine_N68A_human-BCHE Butyrylthiocholine_Q119A_human-BCHE Butyrylthiocholine_Q119E_human-BCHE Butyrylthiocholine_Q119G_human-BCHE Butyrylthiocholine_Q119H_human-BCHE Butyrylthiocholine_Q119K_human-BCHE Butyrylthiocholine_Q119R_human-BCHE Butyrylthiocholine_Q119Y_human-BCHE Butyrylthiocholine_T120E_human-BCHE Butyrylthiocholine_T120G_human-BCHE Butyrylthiocholine_T120H_human-BCHE Butyrylthiocholine_T120K_human-BCHE Butyrylthiocholine_W82Y_human-BCHE Butyrylthiocholine_W82F_human-BCHE Butyrylthiocholine_V127D_human-BCHE Tacrine_WT_human-BCHE Tacrine_D70G_human-BCHE Tacrine_N68D_human-BCHE Tacrine_N68K_human-BCHE Tacrine_N68R_human-BCHE Tacrine_N68Y_human-BCHE Tacrine_N68A_human-BCHE Tacrine_Q119A_human-BCHE Tacrine_Q119E_human-BCHE Tacrine_Q119G_human-BCHE Tacrine_Q119H_human-BCHE Tacrine_Q119K_human-BCHE Tacrine_Q119R_human-BCHE Tacrine_Q119Y_human-BCHE Tacrine_T120E_human-BCHE Tacrine_T120G_human-BCHE Tacrine_T120H_human-BCHE Tacrine_T120K_human-BCHE Tacrine_W82Y_human-BCHE Tacrine_W82F_human-BCHE Tacrine_G115A_human-BCHE Tacrine_G115S_human-BCHE Tacrine_G117E_human-BCHE Tacrine_V127D_human-BCHE Succinylcholine~Suxamethonium_N68D_human-BCHE Succinylcholine~Suxamethonium_N68K_human-BCHE Succinylcholine~Suxamethonium_N68R_human-BCHE Succinylcholine~Suxamethonium_N68Y_human-BCHE Succinylcholine~Suxamethonium_N68A_human-BCHE Succinylcholine~Suxamethonium_Q119A_human-BCHE Succinylcholine~Suxamethonium_Q119E_human-BCHE Succinylcholine~Suxamethonium_Q119G_human-BCHE Succinylcholine~Suxamethonium_Q119H_human-BCHE Succinylcholine~Suxamethonium_Q119K_human-BCHE Succinylcholine~Suxamethonium_Q119R_human-BCHE Succinylcholine~Suxamethonium_Q119Y_human-BCHE Succinylcholine~Suxamethonium_T120E_human-BCHE Succinylcholine~Suxamethonium_T120G_human-BCHE Succinylcholine~Suxamethonium_T120H_human-BCHE Succinylcholine~Suxamethonium_T120K_human-BCHE Succinylcholine~Suxamethonium_W82Y_human-BCHE Succinylcholine~Suxamethonium_W82F_human-BCHE Succinylcholine~Suxamethonium_G115A_human-BCHE Succinylcholine~Suxamethonium_G115S_human-BCHE Succinylcholine~Suxamethonium_G117E_human-BCHE Succinylcholine~Suxamethonium_V127D_human-BCHE Dibucaine_N68D_human-BCHE Dibucaine_N68K_human-BCHE Dibucaine_N68R_human-BCHE Dibucaine_N68Y_human-BCHE Dibucaine_N68A_human-BCHE Dibucaine_Q119A_human-BCHE Dibucaine_Q119E_human-BCHE Dibucaine_Q119G_human-BCHE Dibucaine_Q119H_human-BCHE Dibucaine_Q119K_human-BCHE Dibucaine_Q119R_human-BCHE Dibucaine_Q119Y_human-BCHE Dibucaine_T120E_human-BCHE Dibucaine_T120G_human-BCHE Dibucaine_T120H_human-BCHE Dibucaine_T120K_human-BCHE Dibucaine_W82Y_human-BCHE Dibucaine_W82F_human-BCHE Dibucaine_G115A_human-BCHE Dibucaine_G115S_human-BCHE Dibucaine_G117E_human-BCHE Dibucaine_V127D_human-BCHE Solanine_WT_human-BCHE Solanine_D70G_human-BCHE Solanine_N68D_human-BCHE Solanine_N68K_human-BCHE Solanine_N68R_human-BCHE Solanine_N68Y_human-BCHE Solanine_N68A_human-BCHE Solanine_Q119A_human-BCHE Solanine_Q119E_human-BCHE Solanine_Q119G_human-BCHE Solanine_Q119H_human-BCHE Solanine_Q119K_human-BCHE Solanine_Q119R_human-BCHE Solanine_Q119Y_human-BCHE Solanine_T120E_human-BCHE Solanine_T120G_human-BCHE Solanine_T120H_human-BCHE Solanine_T120K_human-BCHE Solanine_W82Y_human-BCHE Solanine_W82F_human-BCHE Solanine_G115A_human-BCHE Solanine_G115S_human-BCHE Solanine_G117E_human-BCHE Solanine_V127D_human-BCHE BW284C51_WT_human-BCHE BW284C51_D70G_human-BCHE BW284C51_N68D_human-BCHE BW284C51_N68K_human-BCHE BW284C51_N68R_human-BCHE BW284C51_N68Y_human-BCHE BW284C51_N68A_human-BCHE BW284C51_Q119A_human-BCHE BW284C51_Q119E_human-BCHE BW284C51_Q119G_human-BCHE BW284C51_Q119H_human-BCHE BW284C51_Q119K_human-BCHE BW284C51_Q119R_human-BCHE BW284C51_Q119Y_human-BCHE BW284C51_T120E_human-BCHE BW284C51_T120G_human-BCHE BW284C51_T120H_human-BCHE BW284C51_T120K_human-BCHE BW284C51_W82Y_human-BCHE BW284C51_W82F_human-BCHE BW284C51_G115A_human-BCHE BW284C51_G115S_human-BCHE BW284C51_G117E_human-BCHE BW284C51_V127D_human-BCHE Cocaine_WT_human-BCHE Cocaine_D70G_human-BCHE Cocaine_N68K_human-BCHE Cocaine_N68R_human-BCHE Cocaine_Q119K_human-BCHE Cocaine_Q119R_human-BCHE Cocaine_T120K_human-BCHE Cocaine_W82Y_human-BCHE Cocaine_W82F_human-BCHE Cocaine_G115A_human-BCHE Cocaine_G115S_human-BCHE Cocaine_G117E_human-BCHE Acetylthiocholine_WT_human-BCHE Edrophonium_WT_human-BCHE HuperzineA_WT_human-BCHE

No disease

(-)-phenethylcymserine 1,9-dimethyl-methylene-blue 10c-Salicylimine-Tacrine 123I-PIP 2-Chloroprocaine 3,5-dihydroxybenzamido-huprine-hybrid-11 3F9 40V 5-deoxo-3-hydroxyevodiamine-heptyl-carbamate 5-pyrid-3-yl-1,3,4-oxadiazole-5e 5DYT-5hb 5DYW-5hf 5DYW-5hf-C11 5DYW-5hf-F 5DYY-5hh 5LKR-6yc 5NN0-cpd3 6-(2-phenylethyl)-THAI-12b 6EUL-BY2 6F7Q-cpd11 6H6-Heptyl-Carbamate 6QAA-HUN 6QAB-HUQ 6QAC-HUT 6QAD-HUZ 6QAE-HUK 6RUA-3a 6SAM-cpd13 6XTA-cpd18 6ZWE-Cpd3 6o-5-HT3 8012-9656 8AM2-N0C 8IS-7Q1M 8IV-7Q1N 8U2-7AIX7AY-compound5i 8UW-7Q1P 9CI-7Q1O A87-7BO4 Aminoalkyl-tetrahydropyrimido-azocine-7c Amiridine-thiouracil-13c Aprophen Aromatic-tertiary-amine-17c Aroylacrylic-acid-amide-Tacrine-10 Aryl-carboxamide-benzoxazole-cpd36 Ass-IN-10 BChE-HDAC6-IN-2 BChE-IN-21 BChE-IN-3 BChE-IN-9 Benactyzine Benzimidazole-Diethylcarbamoyl-isopentyl-dimethylcarbamate-15d Benzimidazole-Ethoxybenzyl-isopentyl-azetidine-carboxylate-21d Benzimidazole-phenyl-azetidine-carboxylate-11d Benzyloxy-benzylamino-Carltonine-Cpd28 Benzyloxy-benzylamino-Carltonine-Cpd33 Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b C0I-7QHD C4I-7QHE CBD-carbamate-C16 CBDP CHEMBL4079247 CHEMBL4207101 CHEMBL4454960 CHEMBL4454960-PET CHEMBL459756 Caffeic-acid-phenethyl-ester Carltonine-A Carltonine-B Chinese-VX Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b Chlorotacrine-tryptophan-hybrid Choline Cocaine Coumarin-Pyridine-3f Cpd-6-8AI7 Cpd20-Benzimidazol-Oxadiazol DFP DL0410 Decamethonium Di-tert-butyl-phenol-octylamino-cycloheptaquinolin-18d Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 Dihydrobenzodioxepine-cymeserine Dimethylhydroxycarbaphen Donepezil-idebenone-cpd9 Echothiophate Ethopropazine FUB833 Fluoride Goodyschle-A H327 Hup-19 IA4-7BO3 Idalopirdine-rivastigmine Indazole-derivative-4q Indol-thioxotetrahydropyrimidine-Cpd7 Isosorbide-2-benzylcarbamate-5-benzoate Isosorbide-2-benzylcarbamate-5-benzyl-ether Isosorbide-2-benzylcarbamate-5-salicylate Isosorbide-2-butylcarbamate-5-lipoic-acid-ester JU5 JUB MT-031 MTDL-cpd36-diphenylacetamide MTDL-cpd51-diphenylacetamide Malachite-Green Meperidine Mivacurium N-10-Phenothiazine-1-Naphtyl-carbamate N-alkyl-quinuclidine-cpd14 N-demethylhuperzinine PE154 PGN33 Piperidine-4-carboxamide-alkyl-tacrine-cpd16 Propargyl-Tacrine-15 Propidium Pyranone-carbamate-cpd7p Pyridostigmine Quinone-polyamine-NSAID-4 Russian-VX S06-1011 S11-1014 S16-1029 S17-1001 SB-1448 ST052207 Salicylamide-8-Tacrine Sarin Soman Tacrine Tacrine-Sibiriline-Cpd7 Tacrine-methylanacardate-cpd5 Tacrine-pentylmethylene-tolylsulfonamide Tacrine-selegiline-7d Tacrine-selegiline-8g Tetracyclic-carbamate-UW-MD-95 Tetracyclic-carbamate-cp8 Tetracyclic-carbamate-ferulicacid-4a Thioflavin-T Toluidine-Blue Tosyl-L-lysine-chloromethyl-ketone Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k VX VX-Biotin ZINC20166201-cpd8 ZINC59501712 tacrine-isatin-Cpd7d

Sequence

Peptide

EDDIIIATKN GKVRGMNLTV FGGTVTAFLG IPYAQPPLGR LRFKKPQSLT KWSDIWNATK YANSCCQNID QSFPGFHGSE MWNPNTDLSE DCLYLNVWIP APKPKNATVL IWIYGGGFQT GTSSLHVYDG KFLARVERVI VVSMNYRVGA LGFLALPGNP EAPGNMGLFD QQLALQWVQK NIAAFGGNPK SVTLFGESAG AASVSLHLLS PGSHSLFTRA ILQSGSFNAP WAVTSLYEAR NRTLNLAKLT GCSRENETEI IKCLRNKDPQ EILLNEAFVV PYGTPLSVNF GPTVDGDFLT DMPDILLELG QFKKTQILVG VNKDEGTAFL VYGAPGFSKD NNSIITRKEF QEGLKIFFPG VSEFGKESIL FHYTDWVDDQ RPENYREALG DVVGDYNFIC PALEFTKKFS EWGNNAFFYY FEHRSSKLPW PEWMGVMHGY EIEFVFGLPL ERRDNYTKAE EILSRSIVKR WANFAKYGNP NETQNNSTSW PVFKSTEQKY LTLNTESTRI MTKLRAQQCR FWTSFFPKVL EMTGNIDEAE WEWKAGFHRW NNYMMDWKNQ FNDYTSKKES CVGL

References (65)

Title : Onset of Alzheimer disease in apolipoprotein sigma4 carriers is earlier in butyrylcholinesterase K variant carriers - Lane_2024_BMC.Neurol_24_116
Author(s) : Lane RM , Darreh-Shori T , Junge C , Li D , Yang Q , Edwards AL , Graham DL , Moore K , Mummery CJ
Ref : BMC Neurol , 24 :116 , 2024
PubMedID: 38594621
Gene_locus related to this paper: human-BCHE

Title : Butyrylcholinesterase signal sequence self-aggregates and enhances amyloid fibril formation in vitro - Jasiecki_2023_Chem.Biol.Interact_14ChEPon_110783
Author(s) : Jasiecki J , Targonska M , Janaszak-Jasiecka A , Kalinowski L , Waleron K , Wasag B
Ref : Chemico-Biological Interactions , :110783 , 2023
PubMedID: 37884182
Gene_locus related to this paper: human-BCHE

Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301
Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L
Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023
PubMedID: 36996715
Gene_locus related to this paper: human-BCHE

Title : Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies - Jing_2023_Bioorg.Chem_134_106465
Author(s) : Jing L , Wei W , Meng B , Chantegreil F , Nachon F , Martinez A , Wu G , Zhao H , Song Y , Kang D , Brazzolotto X , Zhan P , Liu X
Ref : Bioorg Chem , 134 :106465 , 2023
PubMedID: 36933339
Gene_locus related to this paper: human-BCHE

Title : 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases - Knez_2023_Acta.Pharmaceutica.Sinica.B_13_2152
Author(s) : Knez D , Diez-Iriepa D , Chioua M , Gottinger A , Denic M , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Meden A , Pislar A , Kos J , Zakelj S , Stojan J , Salat K , Serrano J , Patricia Fernandez AP , Sanchez-Garcia A , Martinez-Murillo R , Binda C , Lopez-Munoz F , Gobec S , Marco-Contelle J
Ref : Acta Pharmaceutica Sinica B , 13 :2152 , 2023
PubMedID: 37250172
Gene_locus related to this paper: human-BCHE

Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135
Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B
Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023
PubMedID: 36696766
Gene_locus related to this paper: human-BCHE

Title : Grid-type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions - Nachon_2022_Chembiochem_23_e202200456
Author(s) : Nachon F , Brazzolotto X , Dias J , Courageux C , Drozdz W , Cao XY , Stefankiewicz AR , Lehn JM
Ref : Chembiochem , 23 :e202200456 , 2022
PubMedID: 36193860
Gene_locus related to this paper: human-BCHE

Title : From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series - Meden_2022_Eur.J.Med.Chem_230_114248
Author(s) : Meden A , Knez D , Brazzolotto X , Nachon F , Dias J , Svete J , Stojan J , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 230 :114248 , 2022
PubMedID: 35299116
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Eur.J.Med.Chem_247_115048
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Zorovic M , Denic M , Pajk S , Zivin M , Nachon F , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 247 :115048 , 2022
PubMedID: 36586299
Gene_locus related to this paper: human-BCHE

Title : Pseudo-irreversible butyrylcholinesterase inhibitors: SAR, kinetic, computational, and crystallographic study of the N-dialkyl O-arylcarbamate warhead - Meden_2022_Chemrxiv__
Author(s) : Meden A , Knez D , Brazzolotto X , Modeste F , Perdih A , Pislar A , Zorman M , Denic M , Pajk S , Nachon F , Gobec S
Ref : Chemrxiv , : , 2022
PubMedID:
Gene_locus related to this paper: human-BCHE

Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972
Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021
PubMedID: 33829779
Gene_locus related to this paper: human-BCHE

Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792
Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A
Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021
PubMedID: 34530376
Gene_locus related to this paper: human-BCHE

Title : Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases - Chavarria_2021_Antioxidants.(Basel)_10_329
Author(s) : Chavarria D , Da Silva O , Benfeito S , Barreiro S , Garrido J , Cagide F , Soares P , Remiao F , Brazzolotto X , Nachon F , Oliveira PJ , Dias J , Borges F
Ref : Antioxidants (Basel) , 10 :329 , 2021
PubMedID: 33672269
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors - Meden_2020_Eur.J.Med.Chem_208_112766
Author(s) : Meden A , Knez D , Malikowska-Racia N , Brazzolotto X , Nachon F , Svete J , Salat K , Groselj U , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 208 :112766 , 2020
PubMedID: 32919297
Gene_locus related to this paper: human-BCHE

Title : N-alkylpiperidine carbamates as potential anti-Alzheimer's agents - Kosak_2020_Eur.J.Med.Chem_197_112282
Author(s) : Kosak U , Strasek N , Knez N , Jukic M , Zakelj S , Zahirovic A , Pislar A , Brazzolotto X , Nachon F , Kos J , Gobec S , Knez D
Ref : Eur Journal of Medicinal Chemistry , 197 :112282 , 2020
PubMedID: 32380361
Gene_locus related to this paper: human-BCHE

Title : Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes - Pajk_2020_J.Enzyme.Inhib.Med.Chem_35_498
Author(s) : Pajk S , Knez D , Kosak U , Zorovic M , Brazzolotto X , Coquelle N , Nachon F , Colletier JP , Zivin M , Stojan J , Gobec S
Ref : J Enzyme Inhib Med Chem , 35 :498 , 2020
PubMedID: 31914836
Gene_locus related to this paper: human-BCHE

Title : Enantioseparation, in vitro testing, and structural characterization of triple-binding reactivators of organophosphate-inhibited cholinesterases - Marakovic_2020_Biochem.J_477_2771
Author(s) : Marakovic N , Knezevic A , Roncevic I , Brazzolotto X , Kovarik Z , Sinko G
Ref : Biochemical Journal , 477 :2771 , 2020
PubMedID: 32639532
Gene_locus related to this paper: human-BCHE

Title : Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model. - Dighe_2019_Commun.Chem_2_35
Author(s) : Dighe SN , De la Mora E , Chan S , Kantham S , McColl G , Miles JA , Veliyath SK , Sreenivas BY , Nassar ZD , Silman I , Sussman JL , Weik M , McGeary RP , Parat MO , Brazzolotto X , Ross BP
Ref : Communications chemistry , 2 :35 , 2019
PubMedID:
Gene_locus related to this paper: human-BCHE , torca-ACHE

Title : Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease - Meden_2019_Chem.Commun.(Camb)_55_3765
Author(s) : Meden A , Knez D , Jukic M , Brazzolotto X , Grsic M , Pislar A , Zahirovic A , Kos J , Nachon F , Svete J , Gobec S , Groselj U
Ref : Chem Commun (Camb) , 55 :3765 , 2019
PubMedID: 30864579
Gene_locus related to this paper: human-BCHE

Title : Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly - Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
Author(s) : Leung MR , van Bezouwen LS , Schopfer LM , Sussman JL , Silman I , Lockridge O , Zeev-Ben-Mordehai T
Ref : Proc Natl Acad Sci U S A , 115 :13270 , 2018
PubMedID: 30538207
Gene_locus related to this paper: human-BCHE

Title : Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities - Knez_2018_Eur.J.Med.Chem_156_598
Author(s) : Knez D , Coquelle N , Pislar A , Zakelj S , Jukic M , Sova M , Mravljak J , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Eur Journal of Medicinal Chemistry , 156 :598 , 2018
PubMedID: 30031971
Gene_locus related to this paper: human-BCHE

Title : The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity - Kosak_2018_J.Med.Chem_61_119
Author(s) : Kosak U , Brus B , Knez D , Zakelj S , Trontelj J , Pislar A , Sink R , Jukic M , Zivin M , Podkowa A , Nachon F , Brazzolotto X , Stojan J , Kos J , Coquelle N , Salat K , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 61 :119 , 2018
PubMedID: 29227101
Gene_locus related to this paper: human-BCHE

Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_
Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F
Ref : Molecules , 22 : , 2017
PubMedID: 29186056
Gene_locus related to this paper: human-BCHE

Title : N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents - Kosak_2017_Bioorg.Med.Chem_25_633
Author(s) : Kosak U , Knez D , Coquelle N , Brus B , Pislar A , Nachon F , Brazzolotto X , Kos J , Colletier JP , Gobec S
Ref : Bioorganic & Medicinal Chemistry , 25 :633 , 2017
PubMedID: 27908752
Gene_locus related to this paper: human-BCHE

Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_
Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F
Ref : Molecules , 22 : , 2017
PubMedID: 29077024
Gene_locus related to this paper: human-BCHE

Title : The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment - Schopfer_2017_Molecules_22_
Author(s) : Schopfer LM , Delacour H , Masson P , Leroy J , Krejci E , Lockridge O
Ref : Molecules , 22 : , 2017
PubMedID: 28661448
Gene_locus related to this paper: human-BCHE

Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495
Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S
Ref : Sci Rep , 6 :39495 , 2016
PubMedID: 28000737
Gene_locus related to this paper: human-BCHE

Title : Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening - Dighe_2016_J.Med.Chem_59_7683
Author(s) : Dighe SN , Deora GS , De la Mora E , Nachon F , Chan S , Parat MO , Brazzolotto X , Ross BP
Ref : Journal of Medicinal Chemistry , 59 :7683 , 2016
PubMedID: 27405689
Gene_locus related to this paper: human-BCHE

Title : Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents - Knez_2015_Bioorg.Med.Chem_23_4442
Author(s) : Knez D , Brus B , Coquelle N , Sosic I , Sink R , Brazzolotto X , Mravljak J , Colletier JP , Gobec S
Ref : Bioorganic & Medicinal Chemistry , 23 :4442 , 2015
PubMedID: 26116179
Gene_locus related to this paper: human-BCHE

Title : Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase - Chen_2015_Biochem.J_466_243
Author(s) : Chen X , Huang X , Geng L , Xue L , Hou S , Zheng X , Brimijoin S , Zheng F , Zhan CG
Ref : Biochemical Journal , 466 :243 , 2015
PubMedID: 25486543
Gene_locus related to this paper: human-BCHE

Title : Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor - Brus_2014_J.Med.Chem_57_8167
Author(s) : Brus B , Kosak U , Turk S , Pislar A , Coquelle N , Kos J , Stojan J , Colletier JP , Gobec S
Ref : Journal of Medicinal Chemistry , 57 :8167 , 2014
PubMedID: 25226236
Gene_locus related to this paper: human-BCHE

Title : A highly efficient cocaine-detoxifying enzyme obtained by computational design - Zheng_2014_Nat.Commun_5_3457
Author(s) : Zheng F , Xue L , Hou S , Liu J , Zhan M , Yang W , Zhan CG
Ref : Nat Commun , 5 :3457 , 2014
PubMedID: 24643289
Gene_locus related to this paper: human-BCHE

Title : Amino-acid mutations to extend the biological half-life of a therapeutically valuable mutant of human butyrylcholinesterase - Fang_2014_Chem.Biol.Interact_214C_18
Author(s) : Fang L , Hou S , Xue L , Zheng F , Zhan CG
Ref : Chemico-Biological Interactions , 214C :18 , 2014
PubMedID: 24582612
Gene_locus related to this paper: human-BCHE

Title : A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase - Wandhammer_2013_Chem.Biol.Interact_203_19
Author(s) : Wandhammer M , De Koning MC , van Grol M , Loiodice M , Saurel L , Noort D , Goeldner M , Nachon F
Ref : Chemico-Biological Interactions , 203 :19 , 2013
PubMedID: 22922115
Gene_locus related to this paper: human-BCHE

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry - Carletti_2013_Chem.Res.Toxicol_26_280
Author(s) : Carletti E , Colletier JP , Schopfer LM , Santoni G , Masson P , Lockridge O , Nachon F , Weik M
Ref : Chemical Research in Toxicology , 26 :280 , 2013
PubMedID: 23339663
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905
Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F
Ref : Febs J , 279 :2905 , 2012
PubMedID: 22726956
Gene_locus related to this paper: human-BCHE

Title : X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger - Nachon_2011_Biochem.J_434_73
Author(s) : Nachon F , Carletti E , Wandhammer M , Nicolet Y , Schopfer LM , Masson P , Lockridge O
Ref : Biochemical Journal , 434 :73 , 2011
PubMedID: 21091433
Gene_locus related to this paper: human-BCHE

Title : Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis - Carletti_2011_Chem.Res.Toxicol_24_797
Author(s) : Carletti E , Schopfer LM , Colletier JP , Froment MT , Nachon F , Weik M , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 24 :797 , 2011
PubMedID: 21438623
Gene_locus related to this paper: human-BCHE

Title : Structural study of the complex stereoselectivity of human butyrylcholinesterase for the neurotoxic V-agents - Wandhammer_2011_J.Biol.Chem_286_16783
Author(s) : Wandhammer M , Carletti E , van der Schans M , Gillon E , Nicolet Y , Masson P , Goeldner M , Noort D , Nachon F
Ref : Journal of Biological Chemistry , 286 :16783 , 2011
PubMedID: 21454498
Gene_locus related to this paper: human-BCHE

Title : Cocrystallization studies of full-length recombinant butyrylcholinesterase (BChE) with cocaine - Asojo_2011_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_67_434
Author(s) : Asojo OA , Ngamelue MN , Homma K , Lockridge O
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 67 :434 , 2011
PubMedID: 21505234
Gene_locus related to this paper: human-BCHE

Title : Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. - Carletti_2009_Biochem.J_421_97
Author(s) : Carletti E , Aurbek N , Gillon E , Loiodice M , Nicolet Y , Fontecilla-Camps JC , Masson P , Thiermann H , Nachon F , Worek F
Ref : Biochemical Journal , 421 :97 , 2009
PubMedID: 19368529
Gene_locus related to this paper: human-BCHE

Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011
Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F
Ref : Journal of the American Chemical Society , 130 :16011 , 2008
PubMedID: 18975951
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Mechanisms of cholinesterase inhibition by inorganic mercury - Frasco_2007_FEBS.J_274_1849
Author(s) : Frasco MF , Colletier JP , Weik M , Carvalho F , Guilhermino L , Stojan J , Fournier D
Ref : Febs J , 274 :1849 , 2007
PubMedID: 17355286
Gene_locus related to this paper: human-BCHE

Title : Crystallization and X-ray structure of full-length recombinant human butyrylcholinesterase - Ngamelue_2007_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_63_723
Author(s) : Ngamelue MN , Homma K , Lockridge O , Asojo OA
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 63 :723 , 2007
PubMedID: 17768338
Gene_locus related to this paper: human-BCHE

Title : Naturally occurring mutation Leu307Pro of human butyrylcholinesterase in the Vysya community of India - Manoharan_2006_Pharmacogenet.Genomics_16_461
Author(s) : Manoharan I , Wieseler S , Layer PG , Lockridge O , Boopathy R
Ref : Pharmacogenet Genomics , 16 :461 , 2006
PubMedID: 16788378
Gene_locus related to this paper: human-BCHE

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging - Nachon_2005_Biochemistry_44_1154
Author(s) : Nachon F , Asojo OA , Borgstahl GE , Masson P , Lockridge O
Ref : Biochemistry , 44 :1154 , 2005
PubMedID: 15667209
Gene_locus related to this paper: human-BCHE

Title : Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products - Nicolet_2003_J.Biol.Chem_278_41141
Author(s) : Nicolet Y , Lockridge O , Masson P , Fontecilla-Camps JC , Nachon F
Ref : Journal of Biological Chemistry , 278 :41141 , 2003
PubMedID: 12869558
Gene_locus related to this paper: human-BCHE

Title : Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase - Sun_2002_J.Pharmacol.Exp.Ther_302_710
Author(s) : Sun H , Shen ML , Pang YP , Lockridge O , Brimijoin S
Ref : Journal of Pharmacology & Experimental Therapeutics , 302 :710 , 2002
PubMedID: 12130735
Gene_locus related to this paper: human-BCHE

Title : Re-engineering butyrylcholinesterase as a cocaine hydrolase - Sun_2002_Mol.Pharmacol_62_220
Author(s) : Sun H , Pang YP , Lockridge O , Brimijoin S
Ref : Molecular Pharmacology , 62 :220 , 2002
PubMedID: 12130672
Gene_locus related to this paper: human-BCHE

Title : The sequence of the human genome - Venter_2001_Science_291_1304
Author(s) : Venter JC , Adams MD , Myers EW , Li PW , Mural RJ , Sutton GG , Smith HO , Yandell M , Evans CA , Holt RA , Gocayne JD , Amanatides P , Ballew RM , Huson DH , Wortman JR , Zhang Q , Kodira CD , Zheng XH , Chen L , Skupski M , Subramanian G , Thomas PD , Zhang J , Gabor Miklos GL , Nelson C , Broder S , Clark AG , Nadeau J , McKusick VA , Zinder N , Levine AJ , Roberts RJ , Simon M , Slayman C , Hunkapiller M , Bolanos R , Delcher A , Dew I , Fasulo D , Flanigan M , Florea L , Halpern A , Hannenhalli S , Kravitz S , Levy S , Mobarry C , Reinert K , Remington K , Abu-Threideh J , Beasley E , Biddick K , Bonazzi V , Brandon R , Cargill M , Chandramouliswaran I , Charlab R , Chaturvedi K , Deng Z , Di Francesco V , Dunn P , Eilbeck K , Evangelista C , Gabrielian AE , Gan W , Ge W , Gong F , Gu Z , Guan P , Heiman TJ , Higgins ME , Ji RR , Ke Z , Ketchum KA , Lai Z , Lei Y , Li Z , Li J , Liang Y , Lin X , Lu F , Merkulov GV , Milshina N , Moore HM , Naik AK , Narayan VA , Neelam B , Nusskern D , Rusch DB , Salzberg S , Shao W , Shue B , Sun J , Wang Z , Wang A , Wang X , Wang J , Wei M , Wides R , Xiao C , Yan C , Yao A , Ye J , Zhan M , Zhang W , Zhang H , Zhao Q , Zheng L , Zhong F , Zhong W , Zhu S , Zhao S , Gilbert D , Baumhueter S , Spier G , Carter C , Cravchik A , Woodage T , Ali F , An H , Awe A , Baldwin D , Baden H , Barnstead M , Barrow I , Beeson K , Busam D , Carver A , Center A , Cheng ML , Curry L , Danaher S , Davenport L , Desilets R , Dietz S , Dodson K , Doup L , Ferriera S , Garg N , Gluecksmann A , Hart B , Haynes J , Haynes C , Heiner C , Hladun S , Hostin D , Houck J , Howland T , Ibegwam C , Johnson J , Kalush F , Kline L , Koduru S , Love A , Mann F , May D , McCawley S , McIntosh T , McMullen I , Moy M , Moy L , Murphy B , Nelson K , Pfannkoch C , Pratts E , Puri V , Qureshi H , Reardon M , Rodriguez R , Rogers YH , Romblad D , Ruhfel B , Scott R , Sitter C , Smallwood M , Stewart E , Strong R , Suh E , Thomas R , Tint NN , Tse S , Vech C , Wang G , Wetter J , Williams S , Williams M , Windsor S , Winn-Deen E , Wolfe K , Zaveri J , Zaveri K , Abril JF , Guigo R , Campbell MJ , Sjolander KV , Karlak B , Kejariwal A , Mi H , Lazareva B , Hatton T , Narechania A , Diemer K , Muruganujan A , Guo N , Sato S , Bafna V , Istrail S , Lippert R , Schwartz R , Walenz B , Yooseph S , Allen D , Basu A , Baxendale J , Blick L , Caminha M , Carnes-Stine J , Caulk P , Chiang YH , Coyne M , Dahlke C , Mays A , Dombroski M , Donnelly M , Ely D , Esparham S , Fosler C , Gire H , Glanowski S , Glasser K , Glodek A , Gorokhov M , Graham K , Gropman B , Harris M , Heil J , Henderson S , Hoover J , Jennings D , Jordan C , Jordan J , Kasha J , Kagan L , Kraft C , Levitsky A , Lewis M , Liu X , Lopez J , Ma D , Majoros W , McDaniel J , Murphy S , Newman M , Nguyen T , Nguyen N , Nodell M , Pan S , Peck J , Peterson M , Rowe W , Sanders R , Scott J , Simpson M , Smith T , Sprague A , Stockwell T , Turner R , Venter E , Wang M , Wen M , Wu D , Wu M , Xia A , Zandieh A , Zhu X
Ref : Science , 291 :1304 , 2001
PubMedID: 11181995
Gene_locus related to this paper: human-AADAC , human-ABHD1 , human-ABHD10 , human-ABHD11 , human-ACHE , human-BCHE , human-LDAH , human-ABHD18 , human-CMBL , human-ABHD17A , human-KANSL3 , human-LIPA , human-LYPLAL1 , human-NDRG2 , human-NLGN3 , human-NLGN4X , human-NLGN4Y , human-PAFAH2 , human-PREPL , human-RBBP9 , human-SPG21

Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166
Author(s) : Masson P , Xie W , Froment MT , Lockridge O
Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001
PubMedID: 11341926
Gene_locus related to this paper: human-BCHE

Title : Butyrylcholinesterase genes in individuals with abnormal inhibition numbers and with trace activity: one common mutation and two novel silent genes - Dey_1998_Ann.Clin.Biochem_35_302
Author(s) : Dey DC , Maekawa M , Sudo K , Kanno T
Ref : Annals of Clinical Biochemistry , 35 :302 , 1998
PubMedID: 9547905
Gene_locus related to this paper: human-BCHE

Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237
Author(s) : Millard CB , Lockridge O , Broomfield CA
Ref : Biochemistry , 37 :237 , 1998
PubMedID: 9425044
Gene_locus related to this paper: human-BCHE

Title : Human butyrylcholinesterase L330I mutation belongs to a fluoride-resistant gene, by expression in human fetal kidney cells - Sudo_1997_Biochem.Biophys.Res.Commun_240_372
Author(s) : Sudo K , Maekawa M , Akizuki S , Magara T , Ogasawara H , Tanaka T
Ref : Biochemical & Biophysical Research Communications , 240 :372 , 1997
PubMedID: 9388484
Gene_locus related to this paper: human-BCHE

Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H
Ref : Molecular Pharmacology , 50 :1423 , 1996
PubMedID: 8967962
Gene_locus related to this paper: human-BCHE

Title : Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods -
Author(s) : Greenberg CP , Primo-Parmo SL , Pantuck EJ , La Du BN
Ref : Anesthesia & Analgesia , 81 :419 , 1995
PubMedID: 7618741
Gene_locus related to this paper: human-BCHE

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35
Author(s) : Lockridge O
Ref : Pharmacol Ther , 47 :35 , 1990
PubMedID: 2195556
Gene_locus related to this paper: human-BCHE

Title : Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on in-ovo produced human butyrylcholinesterase - Neville_1990_J.Neurosci.Res_27_452
Author(s) : Neville LF , Gnatt A , Loewenstein Y , Soreq H
Ref : Journal of Neuroscience Research , 27 :452 , 1990
PubMedID: 2079709
Gene_locus related to this paper: human-BCHE

Title : Structure of human serum cholinesterase. -
Author(s) : Lockridge O
Ref : Bioessays , 9 :125 , 1988
PubMedID: 3067729
Gene_locus related to this paper: human-BCHE

Title : Brain cDNA clone for human cholinesterase - McTiernan_1987_Proc.Natl.Acad.Sci.U.S.A_84_6682
Author(s) : McTiernan C , Adkins S , Chatonnet A , Vaughan TA , Bartels CF , Kott M , Rosenberry TL , La Du BN , Lockridge O
Ref : Proceedings of the National Academy of Sciences of the United States of America , 84 :6682 , 1987
PubMedID: 3477799
Gene_locus related to this paper: human-BCHE

Title : Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues - Prody_1987_Proc.Natl.Acad.Sci.U.S.A_84_3555
Author(s) : Prody CA , Zevin-Sonkin D , Gnatt A , Goldberg O , Soreq H
Ref : Proceedings of the National Academy of Sciences of the United States of America , 84 :3555 , 1987
PubMedID: 3035536
Gene_locus related to this paper: human-BCHE

Title : Complete amino acid sequence of human serum cholinesterase - Lockridge_1987_J.Biol.Chem_262_549
Author(s) : Lockridge O , Bartels CF , Vaughan TA , Wong CK , Norton SE , Johnson LL
Ref : Journal of Biological Chemistry , 262 :549 , 1987
PubMedID: 3542989
Gene_locus related to this paper: human-BCHE