F331Y_cimle-ACHE1

General

Gene Locus : cimle-ACHE1

Mode of mutation : Natural mutant

Disease :

Summary : OP-resistance Insecticide resistance Komagata_2021_Insect.Biochem.Mol.Biol__103637

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : OP-resistance

Torpedo_number : 331

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
The position is 348 in the protein corresponding to 331 in Torpedo || p.Phe331Tyr p.Phe348Tyr || . AE027 inhibitor against both WT and resistant (F331Y) AChE, exhibiting IC(50) values of 10 and 43 microM, respectively

References (2)

Title : Identification of a Novel Inhibitor of Cimex lectularius Acetylcholinesterase - Qin_2024_J.Agric.Food.Chem__
Author(s) : Qin J , Yuchi Z
Ref : Journal of Agricultural and Food Chemistry , : , 2024
Abstract :
PubMedSearch : Qin_2024_J.Agric.Food.Chem__
PubMedID: 38771663

Title : Common substitution mutation F348Y of acetylcholinesterase gene contributes to organophosphate and carbamate resistance in Cimex lectularius and C. hemipterus - Komagata_2021_Insect.Biochem.Mol.Biol__103637
Author(s) : Komagata O , Kasai S , Itokawa K , Minagawa K , Kazuma T , Mizutani K , Muto A , Tanikawa T , Adachi M , Komatsu N , Tomita T
Ref : Insect Biochemistry & Molecular Biology , :103637 , 2021
Abstract :
PubMedSearch : Komagata_2021_Insect.Biochem.Mol.Biol__103637
PubMedID: 34454015
Gene_locus related to this paper: cimle-ACHE1