Gene Locus : bovin-thyro
Mode of mutation : Site directed mutagenesis
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification :
Torpedo_number : 25
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
Corresponds to K2223 in human-TG (p.K2204X Thr2204Glu, without 19-aminoacid signal peptide) K2225 residue on the surface of the Cholinesterase-like domain exhibits very close physical proximity with Tg region I. The mutation diminished secretion efficiency although secretory ChEL trafficking wasunaffected
| Title : Structural Features of Thyroglobulin Linked to Protein Trafficking - Citterio_2023_Protein.Sci__e4784 |
| Author(s) : Citterio CE , Kim K , Rajesh B , Pena K , Clarke OB , Arvan P |
| Ref : Protein Science , :e4784 , 2023 |
| Abstract : |
| PubMedSearch : Citterio_2023_Protein.Sci__e4784 |
| PubMedID: 37717261 |
| Gene_locus related to this paper: bovin-thyro , human-TG |