bovin-thyro

Bos taurus (Bovine) Thyroglobulin

Comment

only c-term Pfam A COesterase 2190 2719 here only homologous region starting with first G in cholinesterase 2207

Relationship

Family : Thyroglobulin

Block : C

Position in NCBI Life Tree : Bos taurus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Ruminantia N E > Pecora N E > Bovidae N E > Bovinae N E > Bos N E > Bos taurus N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

HGQLLGRSQA IQVGTSWKPV DQFLGVPYAA PPLGEKRFRA PEHLNWTGSW EATKPRARCW QPGIRTPTPP GVSEDCLYLN VFVPQNMAPN ASVLVFFHNA AEGKGSGDRP AVDGSFLAAV GNLIVVTASY RTGIFGFLSS GSSELSGNWG LLDQVVALTW VQTHIQAFGG DPRRVTLAAD RGGADIASIH LVTTRAANSR LFRRAVLMGG SALSPAAVIR PERARQQAAA LAKEVGCPSS SVQEMVSCLR QEPARILNDA QTKLLAVSGP FHYWGPVVDG QYLRETPARV LQRAPRVKVD LLIGSSQDDG LINRAKAVKQ FEESQGRTSS KTAFYQALQN SLGGEAADAG VQAAATWYYS LEHDSDDYAS FSRALEQATR DYFIICPVID MASHWARTVR GNVFMYHAPE SYSHSSLELL TDVLYAFGLP FYPAYEGQFT LEEKSLSLKI MQYFSNFIRS GNPNYPHEFS RRAPEFAAPW PDFVPRDGAE SYKELSVLLP NRQGLKKADC SFWSKYIQSL KASADETKDG PSADSEEEDQ PAGSGLTEDL LGLPELASKT YSK

References (10)

Title : Structural Features of Thyroglobulin Linked to Protein Trafficking - Citterio_2023_Protein.Sci__e4784
Author(s) : Citterio CE , Kim K , Rajesh B , Pena K , Clarke OB , Arvan P
Ref : Protein Science , :e4784 , 2023
PubMedID: 37717261
Gene_locus related to this paper: bovin-thyro , human-TG

Title : Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin - Marechal_2022_Nat.Commun_13_2380
Author(s) : Marechal N , Serrano BP , Zhang X , Weitz CJ
Ref : Nat Commun , 13 :2380 , 2022
PubMedID: 35501346
Gene_locus related to this paper: bovin-thyro

Title : The structure of natively iodinated bovine thyroglobulin - Kim_2021_Acta.Crystallogr.D.Struct.Biol_77_1451
Author(s) : Kim K , Kopylov M , Bobe D , Kelley K , Eng ET , Arvan P , Clarke OB
Ref : Acta Crystallographica D Struct Biol , 77 :1451 , 2021
PubMedID: 34726172
Gene_locus related to this paper: bovin-thyro

Title : The genome sequence of taurine cattle: a window to ruminant biology and evolution - Elsik_2009_Science_324_522
Author(s) : Elsik CG , Tellam RL , Worley KC , Gibbs RA , Muzny DM , Weinstock GM , Adelson DL , Eichler EE , Elnitski L , Guigo R , Hamernik DL , Kappes SM , Lewin HA , Lynn DJ , Nicholas FW , Reymond A , Rijnkels M , Skow LC , Zdobnov EM , Schook L , Womack J , Alioto T , Antonarakis SE , Astashyn A , Chapple CE , Chen HC , Chrast J , Camara F , Ermolaeva O , Henrichsen CN , Hlavina W , Kapustin Y , Kiryutin B , Kitts P , Kokocinski F , Landrum M , Maglott D , Pruitt K , Sapojnikov V , Searle SM , Solovyev V , Souvorov A , Ucla C , Wyss C , Anzola JM , Gerlach D , Elhaik E , Graur D , Reese JT , Edgar RC , McEwan JC , Payne GM , Raison JM , Junier T , Kriventseva EV , Eyras E , Plass M , Donthu R , Larkin DM , Reecy J , Yang MQ , Chen L , Cheng Z , Chitko-McKown CG , Liu GE , Matukumalli LK , Song J , Zhu B , Bradley DG , Brinkman FS , Lau LP , Whiteside MD , Walker A , Wheeler TT , Casey T , German JB , Lemay DG , Maqbool NJ , Molenaar AJ , Seo S , Stothard P , Baldwin CL , Baxter R , Brinkmeyer-Langford CL , Brown WC , Childers CP , Connelley T , Ellis SA , Fritz K , Glass EJ , Herzig CT , Iivanainen A , Lahmers KK , Bennett AK , Dickens CM , Gilbert JG , Hagen DE , Salih H , Aerts J , Caetano AR , Dalrymple B , Garcia JF , Gill CA , Hiendleder SG , Memili E , Spurlock D , Williams JL , Alexander L , Brownstein MJ , Guan L , Holt RA , Jones SJ , Marra MA , Moore R , Moore SS , Roberts A , Taniguchi M , Waterman RC , Chacko J , Chandrabose MM , Cree A , Dao MD , Dinh HH , Gabisi RA , Hines S , Hume J , Jhangiani SN , Joshi V , Kovar CL , Lewis LR , Liu YS , Lopez J , Morgan MB , Nguyen NB , Okwuonu GO , Ruiz SJ , Santibanez J , Wright RA , Buhay C , Ding Y , Dugan-Rocha S , Herdandez J , Holder M , Sabo A , Egan A , Goodell J , Wilczek-Boney K , Fowler GR , Hitchens ME , Lozado RJ , Moen C , Steffen D , Warren JT , Zhang J , Chiu R , Schein JE , Durbin KJ , Havlak P , Jiang H , Liu Y , Qin X , Ren Y , Shen Y , Song H , Bell SN , Davis C , Johnson AJ , Lee S , Nazareth LV , Patel BM , Pu LL , Vattathil S , Williams RL, Jr. , Curry S , Hamilton C , Sodergren E , Wheeler DA , Barris W , Bennett GL , Eggen A , Green RD , Harhay GP , Hobbs M , Jann O , Keele JW , Kent MP , Lien S , McKay SD , McWilliam S , Ratnakumar A , Schnabel RD , Smith T , Snelling WM , Sonstegard TS , Stone RT , Sugimoto Y , Takasuga A , Taylor JF , Van Tassell CP , Macneil MD , Abatepaulo AR , Abbey CA , Ahola V , Almeida IG , Amadio AF , Anatriello E , Bahadue SM , Biase FH , Boldt CR , Carroll JA , Carvalho WA , Cervelatti EP , Chacko E , Chapin JE , Cheng Y , Choi J , Colley AJ , de Campos TA , De Donato M , Santos IK , de Oliveira CJ , Deobald H , Devinoy E , Donohue KE , Dovc P , Eberlein A , Fitzsimmons CJ , Franzin AM , Garcia GR , Genini S , Gladney CJ , Grant JR , Greaser ML , Green JA , Hadsell DL , Hakimov HA , Halgren R , Harrow JL , Hart EA , Hastings N , Hernandez M , Hu ZL , Ingham A , Iso-Touru T , Jamis C , Jensen K , Kapetis D , Kerr T , Khalil SS , Khatib H , Kolbehdari D , Kumar CG , Kumar D , Leach R , Lee JC , Li C , Logan KM , Malinverni R , Marques E , Martin WF , Martins NF , Maruyama SR , Mazza R , McLean KL , Medrano JF , Moreno BT , More DD , Muntean CT , Nandakumar HP , Nogueira MF , Olsaker I , Pant SD , Panzitta F , Pastor RC , Poli MA , Poslusny N , Rachagani S , Ranganathan S , Razpet A , Riggs PK , Rincon G , Rodriguez-Osorio N , Rodriguez-Zas SL , Romero NE , Rosenwald A , Sando L , Schmutz SM , Shen L , Sherman L , Southey BR , Lutzow YS , Sweedler JV , Tammen I , Telugu BP , Urbanski JM , Utsunomiya YT , Verschoor CP , Waardenberg AJ , Wang Z , Ward R , Weikard R , Welsh TH, Jr. , White SN , Wilming LG , Wunderlich KR , Yang J , Zhao FQ
Ref : Science , 324 :522 , 2009
PubMedID: 19390049
Gene_locus related to this paper: bovin-2neur , bovin-a0jnh8 , bovin-a5d7b7 , bovin-ACHE , bovin-balip , bovin-dpp4 , bovin-dpp6 , bovin-e1bi31 , bovin-e1bn79 , bovin-est8 , bovin-f1mbd6 , bovin-f1mi11 , bovin-f1mr65 , bovin-f1n1l4 , bovin-g3mxp5 , bovin-q0vcc8 , bovin-q2kj30 , bovin-q3t0r6 , bovin-thyro

Title : Thyroglobulin glycosylation: location and nature of the N-linked oligosaccharide units in bovine thyroglobulin - Rawitch_1993_Arch.Biochem.Biophys_300_271
Author(s) : Rawitch AB , Pollock HG , Yang SX
Ref : Archives of Biochemistry & Biophysics , 300 :271 , 1993
PubMedID: 8424663
Gene_locus related to this paper: bovin-thyro

Title : Structural organization of the bovine thyroglobulin gene and of its 5'-flanking region - de Martynoff_1987_Eur.J.Biochem_164_591
Author(s) : de Martynoff G , Pohl V , Mercken L , van Ommen GJ , Vassart G
Ref : European Journal of Biochemistry , 164 :591 , 1987
PubMedID: 3032624
Gene_locus related to this paper: bovin-thyro

Title : Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and exonization during evolution - Parma_1987_J.Mol.Biol_196_769
Author(s) : Parma J , Christophe D , Pohl V , Vassart G
Ref : Journal of Molecular Biology , 196 :769 , 1987
PubMedID: 3681978
Gene_locus related to this paper: bovin-thyro , human-TG

Title : Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA - Mercken_1985_Nature_316_647
Author(s) : Mercken L , Simons MJ , Swillens S , Massaer M , Vassart G
Ref : Nature , 316 :647 , 1985
PubMedID: 3855243
Gene_locus related to this paper: bovin-thyro

Title : Presence of hormonogenic and repetitive domains in the first 930 amino acids of bovine thyroglobulin as deduced from the cDNA sequence - Mercken_1985_Eur.J.Biochem_147_59
Author(s) : Mercken L , Simons MJ , de Martynoff G , Swillens S , Vassart G
Ref : European Journal of Biochemistry , 147 :59 , 1985
PubMedID: 3855750
Gene_locus related to this paper: bovin-thyro

Title : The 5'-end of bovine thyroglobulin mRNA encodes a hormonogenic peptide - Mercken_1982_FEBS.Lett_149_285
Author(s) : Mercken L , Simons MJ , Vassart G
Ref : FEBS Letters , 149 :285 , 1982
PubMedID: 7152045
Gene_locus related to this paper: bovin-thyro