L286Q_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Acyl specificity Acyl pocket, Km X 9 for BTC IC50 high increase for echothiophate and iso-OMPA Gnatt_1994_J.Neurochem_62_749

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Acyl specificity

Torpedo_number : 288

Kinetic Parameter : Butyrylthiocholine_L286Q_human-BCHE, Iso-OMPA_L286Q_human-BCHE, Echothiophate_L286Q_human-BCHE, DFP_L286Q_human-BCHE

News : No news

Comment :
p.L286Q Leu286Gln (p.L314Q Leu314Gln in primary sequence with 28 amino-acids signal peptide) Acyl specificity\;Acyl pocket, Km X 9 for BTC IC50 high increase for echothiophate and iso-OMPA

References (1)

Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749
Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H
Ref : Journal of Neurochemistry , 62 :749 , 1994
PubMedID: 8294937