N506S_ratno-Ces1d

General

Gene Locus : ratno-Ces1d

Mode of mutation : Site directed mutagenesis

Disease :

Summary : cholesteryl esterase activity Ser-506 is required for activation by cAMP-dependent protein kinase Wallace_2001_J.Biol.Chem_276_33165

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : cholesteryl esterase activity

Torpedo_number : 481

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
Increases specific activity against PNPC by 6-fold and against PNPA by 8.7- fold, no activity on cholesteryl oleate. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold\; when associated with I-423. || p.Asn506Ser

References (1)

Title : Mutation of residues 423 (Met\/Ile), 444 (Thr\/Met), and 506 (Asn\/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase - Wallace_2001_J.Biol.Chem_276_33165
Author(s) : Wallace TJ , Kodsi EM , Langston TB , Gergis MR , Grogan WM
Ref : Journal of Biological Chemistry , 276 :33165 , 2001
Abstract :
PubMedSearch : Wallace_2001_J.Biol.Chem_276_33165
PubMedID: 11429416
Gene_locus related to this paper: ratno-Ces1d