Gene Locus : ratno-Ces1d
Mode of mutation : Site directed mutagenesis
Disease :
Summary : cholesteryl esterase activity Ser-506 is required for activation by cAMP-dependent protein kinase Wallace_2001_J.Biol.Chem_276_33165
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : cholesteryl esterase activity
Torpedo_number : 481
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
Increases specific activity against PNPC by 6-fold and against PNPA by 8.7- fold, no activity on cholesteryl oleate. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold\; when associated with I-423. || p.Asn506Ser
| Title : Mutation of residues 423 (Met\/Ile), 444 (Thr\/Met), and 506 (Asn\/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase - Wallace_2001_J.Biol.Chem_276_33165 |
| Author(s) : Wallace TJ , Kodsi EM , Langston TB , Gergis MR , Grogan WM |
| Ref : Journal of Biological Chemistry , 276 :33165 , 2001 |
| Abstract : |
| PubMedSearch : Wallace_2001_J.Biol.Chem_276_33165 |
| PubMedID: 11429416 |
| Gene_locus related to this paper: ratno-Ces1d |