Rattus norvegicus (Rat) Carboxylesterase (ES-HVEL) pI 6.1 esterase (ES-10) CES1D Ces1d
sequence in Wallace et al. L81144 lung cytosolic carboxylesterase and Trembl Q91YG2 1aa different. named ces3 carboxylesterase 3 in trembl Q6P785. || Adipocyte carboxylesterase Q9R135 hepatic neutral cholesteryl ester hydrolase . Mutations S247 in rat carboxylesterase pI6.1(ES10) confirms the importance of this serine (Torpedo 226) for the proper orientation of active site Glu. (Stok et al). Rat testicular carboxylesterase is also liver hydrolase A
Family : Carb_B_Chordata
Block : C
Position in NCBI Life Tree : Rattus norvegicus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Rattus N E > Rattus norvegicus N EMRLYPLVWLF LAACTAWGYP SSPPVVNTVK GKVLGKYVNL EGFAQPVAVF LGIPFAKPPL GSLRFAPPQP AEPWNFVKNT TSYPPMCSQD AVGGQVLSEL FTNRKENIPL QFSEDCLYLN VYTPADLTKN SRLPVMVWIH GGGLVVGGAS TYDGQVLSAH ENVVVVTIQY RLGIWGFFST GDEHSQGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGFSVSAL VLSPLAKNLF HRAISESGVV LTSALITTDS KPIANLIATL SGCKTTTSAV MVHCLRQKTE DELLETSLKL NLFKLDLLGN PKESYPFLPT VIDGVVLPKT PEEILAEKSF NTVPYIVGIN KQEFGWIIPT LMGYPLSEGK LDQKTAKSLL WKSYPTLKIS EKMIPVVAEK YFGGTDDPAK RKDLFQDLVA DVMFGVPSVM VSRSHRDAGA PTFMYEFEYR PSFVSAMRPK TVIGDHGDEL FSVFGSPFLK DGASEEETNL SKMVMKYWAN FARNGNPNGG GLPHWPEYDQ KEGYLKIGAS TQAAQRLKDK EVAFWSELRA KEAAEEPSHW KHVEL
| Title : Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite - Yao_2019_Drug.Metab.Dispos_47_794 |
| Author(s) : Yao H , Bai R , Ren T , Wang Y , Gu J , Guo Y |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 47 :794 , 2019 |
| Abstract : |
| PubMedSearch : Yao_2019_Drug.Metab.Dispos_47_794 |
| PubMedID: 31092394 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Hepatic carboxylesterase 3 (Ces3\/Tgh) is downregulated in the early stages of liver cancer development in the rat - Quiroga_2016_Biochim.Biophys.Acta_1862_2043 |
| Author(s) : Quiroga AD , Ceballos MP , Parody JP , Comanzo CG , Lorenzetti F , Pisani GB , Ronco MT , Alvarez ML , Carrillo MC |
| Ref : Biochimica & Biophysica Acta , 1862 :2043 , 2016 |
| Abstract : |
| PubMedSearch : Quiroga_2016_Biochim.Biophys.Acta_1862_2043 |
| PubMedID: 27523631 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Isolation and characterization of a microsomal acid retinyl ester hydrolase - Linke_2005_J.Biol.Chem_280_23287 |
| Author(s) : Linke T , Dawson H , Harrison EH |
| Ref : Journal of Biological Chemistry , 280 :23287 , 2005 |
| Abstract : |
| PubMedSearch : Linke_2005_J.Biol.Chem_280_23287 |
| PubMedID: 15767260 |
| Gene_locus related to this paper: mouse-Ces1d , ratno-Ces1d |
| Title : Gene and alternative splicing annotation with AIR - Florea_2005_Genome.Res_15_54 |
| Author(s) : Florea L , Di Francesco V , Miller J , Turner R , Yao A , Harris M , Walenz B , Mobarry C , Merkulov GV , Charlab R , Dew I , Deng Z , Istrail S , Li P , Sutton G |
| Ref : Genome Res , 15 :54 , 2005 |
| Abstract : |
| PubMedSearch : Florea_2005_Genome.Res_15_54 |
| PubMedID: 15632090 |
| Gene_locus related to this paper: mouse-Ppgb , rat-d3zaw4 , rat-dpp9 , rat-d3zhq1 , rat-d3zxw8 , rat-d4a4w4 , rat-d4a7w1 , rat-d4a071 , rat-Tex30 , ratno-1plip , ratno-3plip , ratno-ABH15 , ratno-balip , ratno-Ces1d , ratno-d3zxq0 , ratno-est8 , ratno-pbcxe , ratno-phebest , ratno-q6mg55 , ratno-thyro , rat-m0rc77 , rat-d3zba8 , rat-f1lvg7 , rat-b5den3 , rat-d4a1b6 , rat-d3zmg4 |
| Title : Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis - Stok_2004_Arch.Biochem.Biophys_430_247 |
| Author(s) : Stok JE , Goloshchapov A , Song C , Wheelock CE , Derbel MB , Morisseau C , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 430 :247 , 2004 |
| Abstract : |
| PubMedSearch : Stok_2004_Arch.Biochem.Biophys_430_247 |
| PubMedID: 15369824 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate - Sanghani_2002_Eur.J.Biochem_269_4387 |
| Author(s) : Sanghani SP , Davis WI , Dumaual NG , Mahrenholz A , Bosron WF |
| Ref : European Journal of Biochemistry , 269 :4387 , 2002 |
| Abstract : |
| PubMedSearch : Sanghani_2002_Eur.J.Biochem_269_4387 |
| PubMedID: 12230550 |
| Gene_locus related to this paper: ratno-Ces1d , ratno-LOC246252 , ratno-pbcxe |
| Title : Mutation of residues 423 (Met\/Ile), 444 (Thr\/Met), and 506 (Asn\/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase - Wallace_2001_J.Biol.Chem_276_33165 |
| Author(s) : Wallace TJ , Kodsi EM , Langston TB , Gergis MR , Grogan WM |
| Ref : Journal of Biological Chemistry , 276 :33165 , 2001 |
| Abstract : |
| PubMedSearch : Wallace_2001_J.Biol.Chem_276_33165 |
| PubMedID: 11429416 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Molecular cloning and expression of rat lung carboxylesterase and its potential role in the detoxification of organophosphorus compounds - Wallace_1999_Am.J.Respir.Cell.Mol.Biol_20_1201 |
| Author(s) : Wallace TJ , Ghosh S , McLean Grogan W |
| Ref : American Journal of Respiratory Cellular & Molecular Biology , 20 :1201 , 1999 |
| Abstract : |
| PubMedSearch : Wallace_1999_Am.J.Respir.Cell.Mol.Biol_20_1201 |
| PubMedID: 10340939 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Comparison of human and rat metabolism of molinate in liver microsomes and slices - Jewell_1999_Drug.Metab.Dispos_27_842 |
| Author(s) : Jewell WT , Miller MG |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 27 :842 , 1999 |
| Abstract : |
| PubMedSearch : Jewell_1999_Drug.Metab.Dispos_27_842 |
| PubMedID: 10383930 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Identification of a carboxylesterase as the major protein bound by molinate - Jewell_1998_Toxicol.Appl.Pharmacol_149_226 |
| Author(s) : Jewell WT , Miller MG |
| Ref : Toxicol Appl Pharmacol , 149 :226 , 1998 |
| Abstract : |
| PubMedSearch : Jewell_1998_Toxicol.Appl.Pharmacol_149_226 |
| PubMedID: 9571992 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Testicular toxicity of molinate in the rat: metabolic activation via sulfoxidation - Jewell_1998_Toxicol.Appl.Pharmacol_149_159 |
| Author(s) : Jewell WT , Hess RA , Miller MG |
| Ref : Toxicol Appl Pharmacol , 149 :159 , 1998 |
| Abstract : |
| PubMedSearch : Jewell_1998_Toxicol.Appl.Pharmacol_149_159 |
| PubMedID: 9571984 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Molecular aspects of carboxylesterase isoforms in comparison with other esterases - Satoh_1995_Toxicol.Lett_82-83_439 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Toxicol Lett , 82-83 :439 , 1995 |
| Abstract : |
| PubMedSearch : Satoh_1995_Toxicol.Lett_82-83_439 |
| PubMedID: 8597091 |
| Gene_locus related to this paper: human-CES1 , ratno-Ces1d , ratno-lmcxe , ratno-q68g49 |
| Title : Molecular cloning and expression of rat hepatic neutral cholesteryl ester hydrolase - Ghosh_1995_Biochim.Biophys.Acta_1259_305 |
| Author(s) : Ghosh S , Mallonee DH , Hylemon PB , Grogan WM |
| Ref : Biochimica & Biophysica Acta , 1259 :305 , 1995 |
| Abstract : |
| PubMedSearch : Ghosh_1995_Biochim.Biophys.Acta_1259_305 |
| PubMedID: 8541339 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences - Medda_1992_Eur.J.Biochem_206_801 |
| Author(s) : Medda S , Proia RL |
| Ref : European Journal of Biochemistry , 206 :801 , 1992 |
| Abstract : |
| PubMedSearch : Medda_1992_Eur.J.Biochem_206_801 |
| PubMedID: 1606962 |
| Gene_locus related to this paper: ratno-Ces1d , ratno-Ces1e , ratno-CESRRL1 |
| Title : Fatty acid ethyl ester synthase in rat adipose tissue and its relationship to carboxylesterase - Tsujita_1992_J.Biol.Chem_267_23489 |
| Author(s) : Tsujita T , Okuda H |
| Ref : Journal of Biological Chemistry , 267 :23489 , 1992 |
| Abstract : |
| PubMedSearch : Tsujita_1992_J.Biol.Chem_267_23489 |
| PubMedID: 1429692 |
| Gene_locus related to this paper: ratno-Ces1d |
| Title : Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum - Robbi_1990_Biochem.J_269_451 |
| Author(s) : Robbi M , Beaufay H , Octave JN |
| Ref : Biochemical Journal , 269 :451 , 1990 |
| Abstract : |
| PubMedSearch : Robbi_1990_Biochem.J_269_451 |
| PubMedID: 2386485 |
| Gene_locus related to this paper: ratno-Ces1d |