ratno-Ces1d

Rattus norvegicus (Rat) Carboxylesterase (ES-HVEL) pI 6.1 esterase (ES-10) CES1D Ces1d

Comment

sequence in Wallace et al.L81144 lung cytosolic carboxylesterase and Trembl Q91YG2 1aa different. named ces3 carboxylesterase 3 in trembl Q6P785 || Adipocyte carboxylesterase Q9R135 hepatic neutral cholesteryl ester hydrolase . Mutations S247 in rat carboxylesterase pI6.1(ES10) confirms the importance of this serine (Torpedo 226) for the proper orientation of active site Glu. (Stok et al)

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Rattus norvegicus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Rattus N E > Rattus norvegicus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Sequence

Peptide

MRLYPLVWLF LAACTAWGYP SSPPVVNTVK GKVLGKYVNL EGFAQPVAVF LGIPFAKPPL GSLRFAPPQP AEPWNFVKNT TSYPPMCSQD AVGGQVLSEL FTNRKENIPL QFSEDCLYLN VYTPADLTKN SRLPVMVWIH GGGLVVGGAS TYDGQVLSAH ENVVVVTIQY RLGIWGFFST GDEHSQGNWG HLDQVAALHW VQDNIANFGG NPGSVTIFGE SAGGFSVSAL VLSPLAKNLF HRAISESGVV LTSALITTDS KPIANLIATL SGCKTTTSAV MVHCLRQKTE DELLETSLKL NLFKLDLLGN PKESYPFLPT VIDGVVLPKT PEEILAEKSF NTVPYIVGIN KQEFGWIIPT LMGYPLSEGK LDQKTAKSLL WKSYPTLKIS EKMIPVVAEK YFGGTDDPAK RKDLFQDLVA DVMFGVPSVM VSRSHRDAGA PTFMYEFEYR PSFVSAMRPK TVIGDHGDEL FSVFGSPFLK DGASEEETNL SKMVMKYWAN FARNGNPNGG GLPHWPEYDQ KEGYLKIGAS TQAAQRLKDK EVAFWSELRA KEAAEEPSHW KHVEL

References (12)

Title : Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite - Yao_2019_Drug.Metab.Dispos_47_794
Author(s) : Yao H , Bai R , Ren T , Wang Y , Gu J , Guo Y
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 47 :794 , 2019
PubMedID: 31092394
Gene_locus related to this paper: ratno-Ces1d

Title : Hepatic carboxylesterase 3 (Ces3\/Tgh) is downregulated in the early stages of liver cancer development in the rat - Quiroga_2016_Biochim.Biophys.Acta_1862_2043
Author(s) : Quiroga AD , Ceballos MP , Parody JP , Comanzo CG , Lorenzetti F , Pisani GB , Ronco MT , Alvarez ML , Carrillo MC
Ref : Biochimica & Biophysica Acta , 1862 :2043 , 2016
PubMedID: 27523631
Gene_locus related to this paper: ratno-Ces1d

Title : Isolation and characterization of a microsomal acid retinyl ester hydrolase - Linke_2005_J.Biol.Chem_280_23287
Author(s) : Linke T , Dawson H , Harrison EH
Ref : Journal of Biological Chemistry , 280 :23287 , 2005
PubMedID: 15767260
Gene_locus related to this paper: mouse-Ces1d , ratno-Ces1d

Title : Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis - Stok_2004_Arch.Biochem.Biophys_430_247
Author(s) : Stok JE , Goloshchapov A , Song C , Wheelock CE , Derbel MB , Morisseau C , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 430 :247 , 2004
PubMedID: 15369824
Gene_locus related to this paper: ratno-Ces1d

Title : Genome sequence of the Brown Norway rat yields insights into mammalian evolution - Gibbs_2004_Nature_428_493
Author(s) : Gibbs RA , Weinstock GM , Metzker ML , Muzny DM , Sodergren EJ , Scherer S , Scott G , Steffen D , Worley KC , Burch PE , Okwuonu G , Hines S , Lewis L , DeRamo C , Delgado O , Dugan-Rocha S , Miner G , Morgan M , Hawes A , Gill R , Celera , Holt RA , Adams MD , Amanatides PG , Baden-Tillson H , Barnstead M , Chin S , Evans CA , Ferriera S , Fosler C , Glodek A , Gu Z , Jennings D , Kraft CL , Nguyen T , Pfannkoch CM , Sitter C , Sutton GG , Venter JC , Woodage T , Smith D , Lee HM , Gustafson E , Cahill P , Kana A , Doucette-Stamm L , Weinstock K , Fechtel K , Weiss RB , Dunn DM , Green ED , Blakesley RW , Bouffard GG , de Jong PJ , Osoegawa K , Zhu B , Marra M , Schein J , Bosdet I , Fjell C , Jones S , Krzywinski M , Mathewson C , Siddiqui A , Wye N , McPherson J , Zhao S , Fraser CM , Shetty J , Shatsman S , Geer K , Chen Y , Abramzon S , Nierman WC , Havlak PH , Chen R , Durbin KJ , Egan A , Ren Y , Song XZ , Li B , Liu Y , Qin X , Cawley S , Cooney AJ , D'Souza LM , Martin K , Wu JQ , Gonzalez-Garay ML , Jackson AR , Kalafus KJ , McLeod MP , Milosavljevic A , Virk D , Volkov A , Wheeler DA , Zhang Z , Bailey JA , Eichler EE , Tuzun E , Birney E , Mongin E , Ureta-Vidal A , Woodwark C , Zdobnov E , Bork P , Suyama M , Torrents D , Alexandersson M , Trask BJ , Young JM , Huang H , Wang H , Xing H , Daniels S , Gietzen D , Schmidt J , Stevens K , Vitt U , Wingrove J , Camara F , Mar Alba M , Abril JF , Guigo R , Smit A , Dubchak I , Rubin EM , Couronne O , Poliakov A , Hubner N , Ganten D , Goesele C , Hummel O , Kreitler T , Lee YA , Monti J , Schulz H , Zimdahl H , Himmelbauer H , Lehrach H , Jacob HJ , Bromberg S , Gullings-Handley J , Jensen-Seaman MI , Kwitek AE , Lazar J , Pasko D , Tonellato PJ , Twigger S , Ponting CP , Duarte JM , Rice S , Goodstadt L , Beatson SA , Emes RD , Winter EE , Webber C , Brandt P , Nyakatura G , Adetobi M , Chiaromonte F , Elnitski L , Eswara P , Hardison RC , Hou M , Kolbe D , Makova K , Miller W , Nekrutenko A , Riemer C , Schwartz S , Taylor J , Yang S , Zhang Y , Lindpaintner K , Andrews TD , Caccamo M , Clamp M , Clarke L , Curwen V , Durbin R , Eyras E , Searle SM , Cooper GM , Batzoglou S , Brudno M , Sidow A , Stone EA , Payseur BA , Bourque G , Lopez-Otin C , Puente XS , Chakrabarti K , Chatterji S , Dewey C , Pachter L , Bray N , Yap VB , Caspi A , Tesler G , Pevzner PA , Haussler D , Roskin KM , Baertsch R , Clawson H , Furey TS , Hinrichs AS , Karolchik D , Kent WJ , Rosenbloom KR , Trumbower H , Weirauch M , Cooper DN , Stenson PD , Ma B , Brent M , Arumugam M , Shteynberg D , Copley RR , Taylor MS , Riethman H , Mudunuri U , Peterson J , Guyer M , Felsenfeld A , Old S , Mockrin S , Collins F
Ref : Nature , 428 :493 , 2004
PubMedID: 15057822
Gene_locus related to this paper: rat-abhea , rat-abheb , rat-cd029 , rat-d3zaw4 , rat-dpp9 , rat-d3zhq1 , rat-d3zkp8 , rat-d3zuq1 , rat-d3zxw8 , rat-d4a4w4 , rat-d4a7w1 , rat-d4a9l7 , rat-d4a071 , rat-d4aa31 , rat-d4aa33 , rat-d4aa61 , rat-dglb , rat-f1lz91 , rat-Kansl3 , rat-nceh1 , rat-Tex30 , ratno-1hlip , ratno-1neur , ratno-1plip , ratno-2neur , ratno-3neur , ratno-3plip , ratno-ABH15 , ratno-ACHE , ratno-balip , ratno-BCHE , ratno-cauxin , ratno-Ces1d , ratno-Ces1e , ratno-Ces2f , ratno-d3ze31 , ratno-d3zp14 , ratno-d3zxi3 , ratno-d3zxq0 , ratno-d3zxq1 , ratno-d4a3d4 , ratno-d4aa05 , ratno-dpp4 , ratno-dpp6 , ratno-est8 , ratno-FAP , ratno-hyep , ratno-hyes , ratno-kmcxe , ratno-lmcxe , ratno-LOC246252 , ratno-MGLL , ratno-pbcxe , ratno-phebest , ratno-Ppgb , ratno-q4qr68 , ratno-q6ayr2 , ratno-q6q629 , ratno-SPG21 , ratno-thyro , rat-m0rc77 , rat-a0a0g2k9y7 , rat-a0a0g2kb83 , rat-d3zba8 , rat-d3zbj1 , rat-d3zcr8 , rat-d3zxw5 , rat-d4a340 , rat-f1lvg7 , rat-m0r509 , rat-m0r5d4 , rat-b5den3 , rat-d3zxk4 , rat-d4a1b6 , rat-d3zmg4 , rat-ab17c

Title : Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate - Sanghani_2002_Eur.J.Biochem_269_4387
Author(s) : Sanghani SP , Davis WI , Dumaual NG , Mahrenholz A , Bosron WF
Ref : European Journal of Biochemistry , 269 :4387 , 2002
PubMedID: 12230550
Gene_locus related to this paper: ratno-Ces1d , ratno-LOC246252 , ratno-pbcxe

Title : Mutation of residues 423 (Met\/Ile), 444 (Thr\/Met), and 506 (Asn\/Ser) confer cholesteryl esterase activity on rat lung carboxylesterase. Ser-506 is required for activation by cAMP-dependent protein kinase - Wallace_2001_J.Biol.Chem_276_33165
Author(s) : Wallace TJ , Kodsi EM , Langston TB , Gergis MR , Grogan WM
Ref : Journal of Biological Chemistry , 276 :33165 , 2001
PubMedID: 11429416
Gene_locus related to this paper: ratno-Ces1d

Title : Molecular cloning and expression of rat lung carboxylesterase and its potential role in the detoxification of organophosphorus compounds - Wallace_1999_Am.J.Respir.Cell.Mol.Biol_20_1201
Author(s) : Wallace TJ , Ghosh S , McLean Grogan W
Ref : American Journal of Respiratory Cellular & Molecular Biology , 20 :1201 , 1999
PubMedID: 10340939
Gene_locus related to this paper: ratno-Ces1d

Title : Molecular cloning and expression of rat hepatic neutral cholesteryl ester hydrolase - Ghosh_1995_Biochim.Biophys.Acta_1259_305
Author(s) : Ghosh S , Mallonee DH , Hylemon PB , Grogan WM
Ref : Biochimica & Biophysica Acta , 1259 :305 , 1995
PubMedID: 8541339
Gene_locus related to this paper: ratno-Ces1d

Title : The carboxylesterase family exhibits C-terminal sequence diversity reflecting the presence or absence of endoplasmic-reticulum-retention sequences - Medda_1992_Eur.J.Biochem_206_801
Author(s) : Medda S , Proia RL
Ref : European Journal of Biochemistry , 206 :801 , 1992
PubMedID: 1606962
Gene_locus related to this paper: ratno-Ces1d , ratno-Ces1e , ratno-CESRRL1

Title : Nucleotide sequence of cDNA coding for rat liver pI 6.1 esterase (ES-10), a carboxylesterase located in the lumen of the endoplasmic reticulum - Robbi_1990_Biochem.J_269_451
Author(s) : Robbi M , Beaufay H , Octave JN
Ref : Biochemical Journal , 269 :451 , 1990
PubMedID: 2386485
Gene_locus related to this paper: ratno-Ces1d