P75L_drome-ACHE

General

Gene Locus : drome-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Folding Folding (heat-sensitive) some protein with no activity, abnormal electrophoretic migration Mutero_1994_Mol.Gen.Genet_243_699

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Folding

Torpedo_number : 39

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.P75L Pro75Leu AceIJ40 mutant is an heat-sensitive variant. In the homozygous condition, this mutation is lethal when animals are raised at restrictive temperatures, i.e. above 25 degrees C for AceIJ40. The amount of secreted acetylcholinesterase below the lethality threshold of around 25\%

References (1)

Title : Drosophila melanogaster acetylcholinesterase: identification and expression of two mutations responsible for cold- and heat-sensitive phenotypes - Mutero_1994_Mol.Gen.Genet_243_699
Author(s) : Mutero A , Bride JM , Pralavorio M , Fournier D
Ref : Molecular & General Genetics , 243 :699 , 1994
PubMedID: 8028587