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drome-ACHE

Drosophila melanogaster (Fruit fly) acetylcholinesterase H subunit

Comment

Cterminus H peptide || Nucleotide sequence of the Celera sequence differs from the published sequence for this transcript. In particular as pointed out by P. Menozzi & D Fournier position 99 relative to initiation Methionine 99 is R (CGG) instead of G (GGG) || Trembl Q8T0K7 GH25720p of Stapleton et al. only C term

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Drosophila melanogaster

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Protostomia N E > Ecdysozoa N E > Panarthropoda N E > Arthropoda N E > Mandibulata N E > Pancrustacea N E > Hexapoda N E > Insecta N E > Dicondylia N E > Pterygota N E > Neoptera N E > Holometabola N E > Diptera N E > Brachycera N E > Muscomorpha N E > Eremoneura N E > Cyclorrhapha N E > Schizophora N E > Acalyptratae N E > Ephydroidea N E > Drosophilidae N E > Drosophilinae N E > Drosophilini N E > Drosophila [fruit fly, genus] N E > Sophophora N E > melanogaster group N E > melanogaster subgroup N E > Drosophila melanogaster N E

Molecular evidence

A490C\/S571C_drome-ACHE C328V_drome-ACHE C615R_drome-ACHE D248N_drome-ACHE D413A_drome-ACHE D413G_drome-ACHE E107+A_drome-ACHE E107A_drome-ACHE E107K_drome-ACHE E107L_drome-ACHE E107W_drome-ACHE E107Y_drome-ACHE E107del_drome-ACHE E275A_drome-ACHE E275G_drome-ACHE E275Q_drome-ACHE F115S\/F368Y_drome-ACHE F115S\/G303A\/F368Y_drome-ACHE F115S\/I199V\/F368Y_drome-ACHE F115S\/I199V\/G303A\/F368Y_drome-ACHE F115S\/I199V\/G303A_drome-ACHE F115S\/I199V_drome-ACHE F115S_drome-ACHE F368A_drome-ACHE F368C_drome-ACHE F368G_drome-ACHE F368H_drome-ACHE F368I_drome-ACHE F368L_drome-ACHE F368S_drome-ACHE F368V_drome-ACHE F368W_drome-ACHE F368Y_drome-ACHE F409A_drome-ACHE F409G_drome-ACHE G303A\/F368Y_drome-ACHE G303A_drome-ACHE G406A_drome-ACHE I199A_drome-ACHE I199E_drome-ACHE I199G_drome-ACHE I199K_drome-ACHE I199R_drome-ACHE I199T\/G303A_drome-ACHE I199T_drome-ACHE I199V\/F368Y_drome-ACHE I199V\/G303A\/F368Y_drome-ACHE I199V\/G303A_drome-ACHE I199V_drome-ACHE I199W_drome-ACHE I365C\/D413C_drome-ACHE L366A_drome-ACHE L366F_drome-ACHE L392C\/A494C_drome-ACHE L426C\/Q464C_drome-ACHE M191A_drome-ACHE N126D_drome-ACHE N174S_drome-ACHE N331D_drome-ACHE N531D_drome-ACHE N569S_drome-ACHE P75L_drome-ACHE R108V_drome-ACHE R62C\/A207C_drome-ACHE S314F_drome-ACHE T407C\/M514C_drome-ACHE T502C\/S581C_drome-ACHE V356A_drome-ACHE V356D_drome-ACHE W121A\/W359A_drome-ACHE W121A_drome-ACHE W121E_drome-ACHE W121Y_drome-ACHE W309G_drome-ACHE W359+A_drome-ACHE W359A_drome-ACHE W359L_drome-ACHE W359del_drome-ACHE Y109A_drome-ACHE Y109D_drome-ACHE Y109G_drome-ACHE Y109K_drome-ACHE Y111A_drome-ACHE Y111Q_drome-ACHE Y200A_drome-ACHE Y362A_drome-ACHE Y408A_drome-ACHE Y408F_drome-ACHE Y412+A_drome-ACHE Y412A_drome-ACHE Y412del_drome-ACHE

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MAISCRQSRV LPMSLPLPLT IPLPLVLVLS LHLSGVCGVI DRLVVQTSSG PVRGRSVTVQ GREVHVYTGI PYAKPPVEDL RFRKPVPAEP WHGVLDATGL SATCVQERYE YFPGFSGEEI WNPNTNVSED CLYINVWAPA KARLRHGRGA NGGEHPNGKQ ADTDHLIHNG NPQNTTNGLP ILIWIYGGGF MTGSATLDIY NADIMAAVGN VIVASFQYRV GAFGFLHLAP EMPSEFAEEA PGNVGLWDQA LAIRWLKDNA HAFGGNPEWM TLFGESAGSS SVNAQLMSPV TRGLVKRGMM QSGTMNAPWS HMTSEKAVEI GKALINDCNC NASMLKTNPA HVMSCMRSVD AKTISVQQWN SYSGILSFPS APTIDGAFLP ADPMTLMKTA DLKDYDILMG NVRDEGTYFL LYDFIDYFDK DDATALPRDK YLEIMNNIFG KATQAEREAI IFQYTSWEGN PGYQNQQQIG RAVGDHFFTC PTNEYAQALA ERGASVHYYY FTHRTSTSLW GEWMGVLHGD EIEYFFGQPL NNSLQYRPVE RELGKRMLSA VIEFAKTGNP AQDGEEWPNF SKEDPVYYIF STDDKIEKLA RGPLAARCSF WNDYLPKVRS WAGTCDGDSG SASISPRLQL LGIAALIYIC AALRTKRVF

References (8)

Title : Drosophila melanogaster as a model organism for screening acetylcholinesterase reactivators - Macedo_2024_J.Toxicol.Environ.Health.A__1
Author(s) : Macedo PE , Batista JES , Souza LR , Dafre AL , Farina M , Kuca K , Posser T , Pinto PM , Boldo JT , Franco JL
Ref : J Toxicol Environ Health A , :1 , 2024
Abstract :
PubMedSearch : Macedo_2024_J.Toxicol.Environ.Health.A__1
PubMedID: 39292449
Gene_locus related to this paper: drome-ACHE

Title : A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster - Kumar_2021_Biochemistry_60_1312
Author(s) : Kumar K , Mhetre A , Ratnaparkhi GS , Kamat SS
Ref : Biochemistry , 60 :1312 , 2021
Abstract :
PubMedSearch : Kumar_2021_Biochemistry_60_1312
PubMedID: 33827210
Gene_locus related to this paper: drome-1vite , drome-2vite , drome-3vite , drome-ACHE , drome-aes01 , drome-aes02 , drome-aes03 , drome-aes04 , drome-aes05 , drome-aes06 , drome-aes08 , drome-aes09 , drome-aes10 , drome-CG1882 , drome-CG2493 , drome-CG3160 , drome-CG3523 , drome-CG3524 , drome-CG4267 , drome-CG4851 , drome-CG4979 , drome-CG5355 , drome-CG5966 , drome-CG6113 , drome-CG6271 , drome-CG6283 , drome-CG6295 , drome-CG6296 , drome-CG8424 , drome-CG8425 , drome-CG9186 , drome-CG9542 , drome-CG9858 , drome-CG11034 , drome-CG11055 , drome-CG12108 , drome-CG15101 , drome-CG15102 , drome-CG15106 , drome-CG17097 , drome-CG17101 , drome-CG17192 , drome-CG17374 , drome-CG18815 , drome-dnlg1 , drome-est6p , drome-EST23aes07 , drome-este4 , drome-este6 , drome-KRAKEN , drome-OME , harsa-e2bfn3

Title : A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides - Nachon_2020_Molecules_25_1198
Author(s) : Nachon F , Rosenberry TL , Silman I , Sussman JL
Ref : Molecules , 25 :1198 , 2020
Abstract :
PubMedSearch : Nachon_2020_Molecules_25_1198
PubMedID: 32155891
Gene_locus related to this paper: drome-ACHE

Title : Annotation of the Drosophila melanogaster euchromatic genome: a systematic review - Misra_2002_Genome.Biol_3_RESEARCH0083
Author(s) : Misra S , Crosby MA , Mungall CJ , Matthews BB , Campbell KS , Hradecky P , Huang Y , Kaminker JS , Millburn GH , Prochnik SE , Smith CD , Tupy JL , Whitfied EJ , Bayraktaroglu L , Berman BP , Bettencourt BR , Celniker SE , de Grey AD , Drysdale RA , Harris NL , Richter J , Russo S , Schroeder AJ , Shu SQ , Stapleton M , Yamada C , Ashburner M , Gelbart WM , Rubin GM , Lewis SE
Ref : Genome Biol , 3 :RESEARCH0083 , 2002
Abstract :
PubMedSearch : Misra_2002_Genome.Biol_3_RESEARCH0083
PubMedID: 12537572
Gene_locus related to this paper: drome-a1z6g9 , drome-abhd2 , drome-ACHE , drome-CG8058 , drome-CG8093 , drome-CG8233 , drome-CG8425 , drome-CG9059 , drome-CG9186 , drome-CG9542 , drome-CG10982 , drome-CG11309 , drome-CG11406 , drome-CG11598 , drome-CG17097 , drome-glita , drome-KRAKEN , drome-nrtac , drome-OME , drome-q7k274 , drome-q9vux3 , drome-q8mqj5

Title : The genome sequence of Drosophila melanogaster - Adams_2000_Science_287_2185
Author(s) : Adams MD , Celniker SE , Holt RA , Evans CA , Gocayne JD , Amanatides PG , Scherer SE , Li PW , Hoskins RA , Galle RF , George RA , Lewis SE , Richards S , Ashburner M , Henderson SN , Sutton GG , Wortman JR , Yandell MD , Zhang Q , Chen LX , Brandon RC , Rogers YH , Blazej RG , Champe M , Pfeiffer BD , Wan KH , Doyle C , Baxter EG , Helt G , Nelson CR , Gabor GL , Abril JF , Agbayani A , An HJ , Andrews-Pfannkoch C , Baldwin D , Ballew RM , Basu A , Baxendale J , Bayraktaroglu L , Beasley EM , Beeson KY , Benos PV , Berman BP , Bhandari D , Bolshakov S , Borkova D , Botchan MR , Bouck J , Brokstein P , Brottier P , Burtis KC , Busam DA , Butler H , Cadieu E , Center A , Chandra I , Cherry JM , Cawley S , Dahlke C , Davenport LB , Davies P , de Pablos B , Delcher A , Deng Z , Mays AD , Dew I , Dietz SM , Dodson K , Doup LE , Downes M , Dugan-Rocha S , Dunkov BC , Dunn P , Durbin KJ , Evangelista CC , Ferraz C , Ferriera S , Fleischmann W , Fosler C , Gabrielian AE , Garg NS , Gelbart WM , Glasser K , Glodek A , Gong F , Gorrell JH , Gu Z , Guan P , Harris M , Harris NL , Harvey D , Heiman TJ , Hernandez JR , Houck J , Hostin D , Houston KA , Howland TJ , Wei MH , Ibegwam C , Jalali M , Kalush F , Karpen GH , Ke Z , Kennison JA , Ketchum KA , Kimmel BE , Kodira CD , Kraft C , Kravitz S , Kulp D , Lai Z , Lasko P , Lei Y , Levitsky AA , Li J , Li Z , Liang Y , Lin X , Liu X , Mattei B , McIntosh TC , McLeod MP , McPherson D , Merkulov G , Milshina NV , Mobarry C , Morris J , Moshrefi A , Mount SM , Moy M , Murphy B , Murphy L , Muzny DM , Nelson DL , Nelson DR , Nelson KA , Nixon K , Nusskern DR , Pacleb JM , Palazzolo M , Pittman GS , Pan S , Pollard J , Puri V , Reese MG , Reinert K , Remington K , Saunders RD , Scheeler F , Shen H , Shue BC , Siden-Kiamos I , Simpson M , Skupski MP , Smith T , Spier E , Spradling AC , Stapleton M , Strong R , Sun E , Svirskas R , Tector C , Turner R , Venter E , Wang AH , Wang X , Wang ZY , Wassarman DA , Weinstock GM , Weissenbach J , Williams SM , WoodageT , Worley KC , Wu D , Yang S , Yao QA , Ye J , Yeh RF , Zaveri JS , Zhan M , Zhang G , Zhao Q , Zheng L , Zheng XH , Zhong FN , Zhong W , Zhou X , Zhu S , Zhu X , Smith HO , Gibbs RA , Myers EW , Rubin GM , Venter JC
Ref : Science , 287 :2185 , 2000
Abstract :
PubMedSearch : Adams_2000_Science_287_2185
PubMedID: 10731132
Gene_locus related to this paper: drome-1vite , drome-2vite , drome-3vite , drome-a1z6g9 , drome-abhd2 , drome-ACHE , drome-b6idz4 , drome-BEM46 , drome-CG5707 , drome-CG5704 , drome-CG1309 , drome-CG1882 , drome-CG1986 , drome-CG2059 , drome-CG2493 , drome-CG2528 , drome-CG2772 , drome-CG3160 , drome-CG3344 , drome-CG3523 , drome-CG3524 , drome-CG3734 , drome-CG3739 , drome-CG3744 , drome-CG3841 , drome-CG4267 , drome-CG4382 , drome-CG4390 , drome-CG4572 , drome-CG4582 , drome-CG4851 , drome-CG4979 , drome-CG5068 , drome-CG5162 , drome-CG5355 , drome-CG5377 , drome-CG5397 , drome-CG5412 , drome-CG5665 , drome-CG5932 , drome-CG5966 , drome-CG6018 , drome-CG6113 , drome-CG6271 , drome-CG6283 , drome-CG6295 , drome-CG6296 , drome-CG6414 , drome-CG6431 , drome-CG6472 , drome-CG6567 , drome-CG6675 , drome-CG6753 , drome-CG6847 , drome-CG7329 , drome-CG7367 , drome-CG7529 , drome-CG7632 , drome-CG8058 , drome-CG8093 , drome-CG8233 , drome-CG8424 , drome-CG8425 , drome-CG9059 , drome-CG9186 , drome-CG9287 , drome-CG9289 , drome-CG9542 , drome-CG9858 , drome-CG9953 , drome-CG9966 , drome-CG10116 , drome-CG10163 , drome-CG10175 , drome-CG10339 , drome-CG10357 , drome-CG10982 , drome-CG11034 , drome-CG11055 , drome-CG11309 , drome-CG11319 , drome-CG11406 , drome-CG11598 , drome-CG11600 , drome-CG11608 , drome-CG11626 , drome-CG11935 , drome-CG12108 , drome-CG12869 , drome-CG13282 , drome-CG13562 , drome-CG13772 , drome-CG14034 , drome-nlg3 , drome-CG14717 , drome-CG15101 , drome-CG15102 , drome-CG15106 , drome-CG15111 , drome-CG15820 , drome-CG15821 , drome-CG15879 , drome-CG17097 , drome-CG17099 , drome-CG17101 , drome-CG17191 , drome-CG17192 , drome-CG17292 , drome-CG18258 , drome-CG18284 , drome-CG18301 , drome-CG18302 , drome-CG18493 , drome-CG18530 , drome-CG18641 , drome-CG18815 , drome-CG31089 , drome-CG31091 , drome-CG32333 , drome-CG32483 , drome-CG33174 , drome-dnlg1 , drome-este4 , drome-este6 , drome-GH02384 , drome-GH02439 , drome-glita , drome-KRAKEN , drome-lip1 , drome-LIP2 , drome-lip3 , drome-MESK2 , drome-nrtac , drome-OME , drome-q7k274 , drome-Q9VJN0 , drome-Q8IP31 , drome-q9vux3 , drome-q8mqj5

Title : Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors - Harel_2000_Protein.Sci_9_1063
Author(s) : Harel M , Kryger G , Rosenberry TL , Mallender WD , Lewis T , Fletcher RJ , Guss JM , Silman I , Sussman JL
Ref : Protein Science , 9 :1063 , 2000
Abstract :
PubMedSearch : Harel_2000_Protein.Sci_9_1063
PubMedID: 10892800
Gene_locus related to this paper: drome-ACHE

Title : Multiple sources of character information and the phylogeny of Hawaiian Drosophila - Baker_1997_Syst.Biol_46_654
Author(s) : Baker RH , Desalle R
Ref : Syst Biol , 46 :654 , 1997
Abstract :
PubMedSearch : Baker_1997_Syst.Biol_46_654
PubMedID: 11975337
Gene_locus related to this paper: drome-ACHE

Title : The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5' leader - Hall_1986_EMBO.J_5_2949
Author(s) : Hall LM , Spierer P
Ref : EMBO Journal , 5 :2949 , 1986
Abstract :
PubMedSearch : Hall_1986_EMBO.J_5_2949
PubMedID: 3024971
Gene_locus related to this paper: drome-ACHE