Gene Locus : drome-ACHE
Mode of mutation : Random
Disease :
Summary : Folding Folding (cold-sensitive) AceIJ29 mutation decrease secretion rates in xenopus oocyte Mutero_1994_Mol.Gen.Genet_243_699
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Folding
Torpedo_number : 238
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
AceIJ29 mutant is a cold-sensitive variant. In the homozygous condition, this mutation is lethal when animals are raised at restrictive temperatures, i.e. below 23 degrees C for AceIJ29. The amount of secreted acetylcholinesterase below the lethality threshold of around 25\% || p.Ser314Phe
| Title : Drosophila melanogaster acetylcholinesterase: identification and expression of two mutations responsible for cold- and heat-sensitive phenotypes - Mutero_1994_Mol.Gen.Genet_243_699 |
| Author(s) : Mutero A , Bride JM , Pralavorio M , Fournier D |
| Ref : Molecular & General Genetics , 243 :699 , 1994 |
| Abstract : |
| PubMedSearch : Mutero_1994_Mol.Gen.Genet_243_699 |
| PubMedID: 8028587 |