W177C_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Natural mutant

Disease :

Summary : atural mutant Succinylcholine hydrolysis Millet_2021_Anaesth.Crit.Care.Pain.Med__100847

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Succinylcholine hydrolysis

Torpedo_number : 179

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.W177C Trp177Cys (p.W205C Trp205Cys in primary sequence with 28 amino-acids signal peptide) seems to be associated with prolonged post suxamethonium apnoea

References (1)

Title : Phenotype and genotype characteristics of 58 patients showing a prolonged effect of succinylcholine: a four-year experience - Millet_2021_Anaesth.Crit.Care.Pain.Med__100847
Author(s) : Millet C , Plaud B , Delacour H
Ref : Anaesth Crit Care Pain Med , :100847 , 2021
Abstract :
PubMedSearch : Millet_2021_Anaesth.Crit.Care.Pain.Med__100847
PubMedID: 33774263