Y124Q_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Acyl specificity\;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE\;Kaplan_2001_Biochemistry_40_7433

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Acyl specificity

Torpedo_number : 121

Kinetic Parameter : Acetylthiocholine_Y124Q_human-ACHE, Butyrylthiocholine_Y124Q_human-ACHE

News : No news

Comment : "Y124Q p.Tyr124Gln (Y155Q p.Tyr155Gln in primary sequence with 31 amino-acids signal peptide) Acyl specificity\;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE"

References (1)

Title : Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? - Kaplan_2001_Biochemistry_40_7433
Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Velan B , Shafferman A
Ref : Biochemistry , 40 :7433 , 2001
Abstract : Kaplan_2001_Biochemistry_40_7433
ESTHER : Kaplan_2001_Biochemistry_40_7433
PubMedSearch : Kaplan_2001_Biochemistry_40_7433
PubMedID: 11412096