Shafferman A

General

Full name : Shafferman Avigdor

First name : Avigdor

Mail : Israel Institute for Biological Research\; POB 19\; Ness Ziona 74100

Zip Code :

City :

Country : Israel

Email : avigdors@iibr.gov.il

Phone : +97289381595

Fax : 972-8-401404

Website :

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References (102)

Title : Progress and novel strategies in vaccine development and treatment of anthrax - Chitlaru_2011_Immunol.Rev_239_221
Author(s) : Chitlaru T , Altboum Z , Reuveny S , Shafferman A
Ref : Immunol Rev , 239 :221 , 2011
Abstract :
PubMedSearch : Chitlaru_2011_Immunol.Rev_239_221
PubMedID: 21198675

Title : Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics - Kronman_2010_Chem.Biol.Interact_187_253
Author(s) : Kronman C , Cohen O , Mazor O , Ordentlich A , Raveh L , Velan B , Shafferman A
Ref : Chemico-Biological Interactions , 187 :253 , 2010
Abstract :
PubMedSearch : Kronman_2010_Chem.Biol.Interact_187_253
PubMedID: 20005217

Title : Postexposure immunization with modified vaccinia virus Ankara or conventional Lister vaccine provides solid protection in a murine model of human smallpox - Paran_2009_J.Infect.Dis_199_39
Author(s) : Paran N , Suezer Y , Lustig S , Israely T , Schwantes A , Melamed S , Katz L , Preuss T , Hanschmann KM , Kalinke U , Erez N , Levin R , Velan B , Lower J , Shafferman A , Sutter G
Ref : J Infect Dis , 199 :39 , 2009
Abstract :
PubMedSearch : Paran_2009_J.Infect.Dis_199_39
PubMedID: 19012492

Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213
Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A
Ref : Biochemical Journal , 417 :213 , 2009
Abstract :
PubMedSearch : Barak_2009_Biochem.J_417_213
PubMedID: 18729824

Title : Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response - Lustig_2009_Vaccine_27_1691
Author(s) : Lustig S , Maik-Rachline G , Paran N , Melamed S , Israely T , Erez N , Orr N , Reuveny S , Ordentlich A , Laub O , Shafferman A , Velan B
Ref : Vaccine , 27 :1691 , 2009
Abstract :
PubMedSearch : Lustig_2009_Vaccine_27_1691
PubMedID: 19195492

Title : Flexibility versus rigidity of the functional architecture of AChE active center - Shafferman_2008_Chem.Biol.Interact_175_166
Author(s) : Shafferman A , Barak D , Stein D , Kronman C , Velan B , Greig NH , Ordentlich A
Ref : Chemico-Biological Interactions , 175 :166 , 2008
Abstract :
PubMedSearch : Shafferman_2008_Chem.Biol.Interact_175_166
PubMedID: 18471807

Title : Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase - Mazor_2008_Mol.Pharmacol_74_755
Author(s) : Mazor O , Cohen O , Kronman C , Raveh L , Stein D , Ordentlich A , Shafferman A
Ref : Molecular Pharmacology , 74 :755 , 2008
Abstract :
PubMedSearch : Mazor_2008_Mol.Pharmacol_74_755
PubMedID: 18523134

Title : Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants - Cohen_2007_J.Biol.Chem_282_35491
Author(s) : Cohen O , Kronman C , Lazar A , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 282 :35491 , 2007
Abstract :
PubMedSearch : Cohen_2007_J.Biol.Chem_282_35491
PubMedID: 17932038

Title : Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication - Kronman_2007_Toxicology_233_40
Author(s) : Kronman C , Cohen O , Raveh L , Mazor O , Ordentlich A , Shafferman A
Ref : Toxicology , 233 :40 , 2007
Abstract :
PubMedSearch : Kronman_2007_Toxicology_233_40
PubMedID: 17045722

Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174
Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH
Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006
Abstract :
PubMedSearch : Luo_2006_J.Med.Chem_49_2174
PubMedID: 16570913

Title : Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds - Cohen_2006_Mol.Pharmacol_70_1121
Author(s) : Cohen O , Kronman C , Raveh L , Mazor O , Ordentlich A , Shafferman A
Ref : Molecular Pharmacology , 70 :1121 , 2006
Abstract :
PubMedSearch : Cohen_2006_Mol.Pharmacol_70_1121
PubMedID: 16801396

Title : Effects of spontaneous deamidation on the cytotoxic activity of the Bacillus anthracis protective antigen - Zomber_2005_J.Biol.Chem_280_39897
Author(s) : Zomber G , Reuveny S , Garti N , Shafferman A , Elhanany E
Ref : Journal of Biological Chemistry , 280 :39897 , 2005
Abstract :
PubMedSearch : Zomber_2005_J.Biol.Chem_280_39897
PubMedID: 16188881

Title : Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents - Barak_2005_Chem.Biol.Interact_157-158_219
Author(s) : Barak D , Ordentlich A , Kaplan D , Kronman C , Velan B , Shafferman A
Ref : Chemico-Biological Interactions , 157-158 :219 , 2005
Abstract :
PubMedSearch : Barak_2005_Chem.Biol.Interact_157-158_219
PubMedID: 16289124

Title : The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers - Ordentlich_2005_Chem.Biol.Interact_157-158_191
Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A
Ref : Chemico-Biological Interactions , 157-158 :191 , 2005
Abstract :
PubMedSearch : Ordentlich_2005_Chem.Biol.Interact_157-158_191
PubMedID: 16289014

Title : Host-regulated disposition of mammalian AChEs - Kronman_2005_Chem.Biol.Interact_157-158_51
Author(s) : Kronman C , Cohen O , Velan B , Shafferman A
Ref : Chemico-Biological Interactions , 157-158 :51 , 2005
Abstract :
PubMedSearch : Kronman_2005_Chem.Biol.Interact_157-158_51
PubMedID: 16289063

Title : Functional requirements for the optimal catalytic configuration of the AChE active center - Shafferman_2005_Chem.Biol.Interact_157-158_123
Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Kronman C , Velan B
Ref : Chemico-Biological Interactions , 157-158 :123 , 2005
Abstract :
PubMedSearch : Shafferman_2005_Chem.Biol.Interact_157-158_123
PubMedID: 16256968

Title : Some basic rules governing oligosaccharide-dependent circulatory residence of glycoproteins are revealed by MALDI-TOF mapping of the multiple N-glycans associated with recombinant bovine acetylcholinesterase. -
Author(s) : Kronman C , Chitlaru T , Seliger N , Lazar S , Lazar A , Zilberstein L , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :613 , 2004
PubMedID:

Title : Effect of post-translation modifications of human acetylcholinesterase on its circulatory residence. -
Author(s) : Chitlaru T , Kronman C , Lazar S , Seliger N , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :511 , 2004
PubMedID:

Title : Generation of pharmacokinetically improved recombinant human acetylcholinesterase by polyethylene glycol modification. -
Author(s) : Cohen O , Kronman C , Chitlaru T , Ordentlich A , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :519 , 2004
PubMedID:

Title : Attempts to engineer an enzyme mimic of butyrylcholinesterase by substitution of the six divergent aromatic amino acids in the active center of acetylcholinesterase. -
Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Baruch V , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :601 , 2004
PubMedID:

Title : A complex array of post-translation modifications determines the circulatory longevity of acetylcholinesterase in a hierarchical manner. -
Author(s) : Shafferman A , Chitlaru T , Ordentlich A , Velan B , Kronman C
Ref : Cholinergic Mechanisms, CRC Press :245 , 2004
PubMedID:

Title : MALDI-TOF\/MS analysis of tabun-acetylcholinesterase conjugate. -
Author(s) : Elhanany E , Ordentlich A , Dgany OR , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :563 , 2004
PubMedID:

Title : Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE - Ordentlich_2004_Biochemistry_43_11255
Author(s) : Ordentlich A , Barak D , Sod-Moriah G , Kaplan D , Mizrahi D , Segall Y , Kronman C , Karton Y , Lazar A , Marcus D , Velan B , Shafferman A
Ref : Biochemistry , 43 :11255 , 2004
Abstract :
PubMedSearch : Ordentlich_2004_Biochemistry_43_11255
PubMedID: 15366935

Title : Poster (14) The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases -
Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :327 , 2004
PubMedID:

Title : The aromatic trapping of histidine 447 in catalysis of acetylcholinesterases -
Author(s) : Shafferman A , Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :181 , 2004
PubMedID:

Title : Poster (21) Analysis of acetylcholinesterase adducts of alzheimer's drugs -
Author(s) : Ordentlich A , Kronman C , Barak D , Ariel N , Kaplan D , Velan B , Shafferman A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004
PubMedID:

Title : Poster (23) Phosphorylation and aging of AChE - insights from mutagenesis, mass spectrometry and structural studies -
Author(s) : Barak D , Ordentlich A , Kaplan D , Elhanani E , Segall Y , Barak R , Velan B , Shafferman A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :332 , 2004
PubMedID:

Title : Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase? - Kaplan_2004_Biochemistry_43_3129
Author(s) : Kaplan D , Barak D , Ordentlich A , Kronman C , Velan B , Shafferman A
Ref : Biochemistry , 43 :3129 , 2004
Abstract :
PubMedSearch : Kaplan_2004_Biochemistry_43_3129
PubMedID: 15023064

Title : Poster (35) The hierarchy of post-translation modifications determining circulatory longevity of acetylcholinesterase. -
Author(s) : Velan B , Kronman C , Chitlaru T , Cohen O , Ordentlich A , Shafferman A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :339 , 2004
PubMedID:

Title : Surprising findings from the functional analysis of human acetylcholinesterase adducts of Alzheimer?s disease drugs. -
Author(s) : Ordentlich A , Barak D , Ariel N , Kronman C , Kaplan D , Velan B , Shafferman A
Ref : Cholinergic Mechanisms, CRC Press :177 , 2004
PubMedID:

Title : Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta) - Cohen_2004_Biochem.J_378_117
Author(s) : Cohen O , Kronman C , Velan B , Shafferman A
Ref : Biochemical Journal , 378 :117 , 2004
Abstract :
PubMedSearch : Cohen_2004_Biochem.J_378_117
PubMedID: 14575524
Gene_locus related to this paper: macmu-ACHE

Title : Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability - Clery-Barraud_2002_Eur.J.Biochem_269_4297
Author(s) : Clery-Barraud C , Ordentlich A , Grosfeld H , Shafferman A , Masson P
Ref : European Journal of Biochemistry , 269 :4297 , 2002
Abstract :
PubMedSearch : Clery-Barraud_2002_Eur.J.Biochem_269_4297
PubMedID: 12199708

Title : The aromatic trapping of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase - Barak_2002_Biochemistry_41_8245
Author(s) : Barak D , Kaplan D , Ordentlich A , Ariel N , Velan B , Shafferman A
Ref : Biochemistry , 41 :8245 , 2002
Abstract :
PubMedSearch : Barak_2002_Biochemistry_41_8245
PubMedID: 12081473

Title : Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time - Chitlaru_2002_Biochem.J_363_619
Author(s) : Chitlaru T , Kronman C , Velan B , Shafferman A
Ref : Biochemical Journal , 363 :619 , 2002
Abstract :
PubMedSearch : Chitlaru_2002_Biochem.J_363_619
PubMedID: 11964163

Title : Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity - Cohen_2001_Biochem.J_357_795
Author(s) : Cohen O , Kronman C , Chitlaru T , Ordentlich A , Velan B , Shafferman A
Ref : Biochemical Journal , 357 :795 , 2001
Abstract :
PubMedSearch : Cohen_2001_Biochem.J_357_795
PubMedID: 11463350

Title : Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? - Kaplan_2001_Biochemistry_40_7433
Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Velan B , Shafferman A
Ref : Biochemistry , 40 :7433 , 2001
Abstract :
PubMedSearch : Kaplan_2001_Biochemistry_40_7433
PubMedID: 11412096

Title : Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: maldi-tof\/ms analysis of various nerve agent phosphyl adducts - Elhanany_2001_Chem.Res.Toxicol_14_912
Author(s) : Elhanany E , Ordentlich A , Dgany O , Kaplan D , Segall Y , Barak R , Velan B , Shafferman A
Ref : Chemical Research in Toxicology , 14 :912 , 2001
Abstract :
PubMedSearch : Elhanany_2001_Chem.Res.Toxicol_14_912
PubMedID: 11453739

Title : Effect of human acetylcholinesterase subunit assembly on its circulatory residence - Chitlaru_2001_Biochem.J_354_613
Author(s) : Chitlaru T , Kronman C , Velan B , Shafferman A
Ref : Biochemical Journal , 354 :613 , 2001
Abstract :
PubMedSearch : Chitlaru_2001_Biochem.J_354_613
PubMedID: 11237866

Title : Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II - Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
Author(s) : Kryger G , Harel M , Giles K , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL
Ref : Acta Crystallographica D Biol Crystallogr , 56 :1385 , 2000
Abstract :
PubMedSearch : Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385
PubMedID: 11053835
Gene_locus related to this paper: human-ACHE

Title : Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase - Kronman_2000_J.Biol.Chem_275_29488
Author(s) : Kronman C , Chitlaru T , Elhanany E , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 275 :29488 , 2000
Abstract :
PubMedSearch : Kronman_2000_J.Biol.Chem_275_29488
PubMedID: 10867010

Title : Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax - Cohen_2000_Infect.Immun_68_4549
Author(s) : Cohen S , Mendelson I , Altboum Z , Kobiler D , Elhanany E , Bino T , Leitner M , Inbar I , Rosenberg H , Gozes Y , Barak R , Fisher M , Kronman C , Velan B , Shafferman A
Ref : Infect Immun , 68 :4549 , 2000
Abstract :
PubMedSearch : Cohen_2000_Infect.Immun_68_4549
PubMedID: 10899854

Title : Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase - Barak_2000_Biochemistry_39_1156
Author(s) : Barak D , Ordentlich A , Kaplan D , Barak R , Mizrahi D , Kronman C , Segall Y , Velan B , Shafferman A
Ref : Biochemistry , 39 :1156 , 2000
Abstract :
PubMedSearch : Barak_2000_Biochemistry_39_1156
PubMedID: 10653663

Title : Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition - Malany_1999_Chem.Biol.Interact_119-120_99
Author(s) : Malany S , Baker NA , Verweyst M , Medhekar R , Quinn DM , Velan B , Kronman C , Shafferman A
Ref : Chemico-Biological Interactions , 119-120 :99 , 1999
Abstract :
PubMedSearch : Malany_1999_Chem.Biol.Interact_119-120_99
PubMedID: 10421443

Title : Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers - Ordentlich_1999_Biochemistry_38_3055
Author(s) : Ordentlich A , Barak D , Kronman C , Benschop HP , De Jong LP , Ariel N , Barak R , Segall Y , Velan B , Shafferman A
Ref : Biochemistry , 38 :3055 , 1999
Abstract :
PubMedSearch : Ordentlich_1999_Biochemistry_38_3055
PubMedID: 10074358

Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032
Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : Biochemistry , 38 :7032 , 1999
Abstract :
PubMedSearch : Millard_1999_Biochemistry_38_7032
PubMedID: 10353814
Gene_locus related to this paper: torca-ACHE

Title : Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad - Millard_1999_J.Am.Chem.Soc_121_9883
Author(s) : Millard CB , Koellner G , Ordentlich A , Shafferman A , Silman I , Sussman JL
Ref : Journal of the American Chemical Society , 121 :9883 , 1999
Abstract :
PubMedSearch : Millard_1999_J.Am.Chem.Soc_121_9883
PubMedID:
Gene_locus related to this paper: torca-ACHE

Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43
Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL
Ref : Chemico-Biological Interactions , 119-120 :43 , 1999
Abstract :
PubMedSearch : Silman_1999_Chem.Biol.Interact_119-120_43
PubMedID: 10421437
Gene_locus related to this paper: torca-ACHE

Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998
PubMedID:

Title : Functional characteristics of the oxyanion hole in human acetylcholinesterase - Ordentlich_1998_J.Biol.Chem_273_19509
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 273 :19509 , 1998
Abstract :
PubMedSearch : Ordentlich_1998_J.Biol.Chem_273_19509
PubMedID: 9677373

Title : Assembly of Acetylcholinesterase Subunits in vitro -
Author(s) : Giles K , Ben-Yohanan R , Velan B , Shafferman A , Sussman JL , Silman I
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :442 , 1998
PubMedID:

Title : Bovine Acetylcholinestrase Cloning, Expression and Characterization of the Recombinant Enzyme -
Author(s) : Mendelson I , Kronman C , Zeliger N , Seri T , Ordentlich A , Shafferman A , Velan B
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :148 , 1998
PubMedID:

Title : Structural Modifications of the Omega Loop in Human Acetylcholinesterase -
Author(s) : Ariel N , Velan B , Barak D , Leitner M , Bino T , Ordentlich A , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :453 , 1998
PubMedID:

Title : Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :454 , 1998
PubMedID:

Title : Contribution of the Active Center Functional Architecture to AChE Reactivity Toward Substrates and Inhibitors -
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Velan B
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :203 , 1998
PubMedID:

Title : Correlation of Isotope and Viscosity Effects -
Author(s) : Malany S , Taylor P , Quinn DM , Sawai M , Shafferman A , Velan B , Kronman C
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :232 , 1998
PubMedID:

Title : Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE? -
Author(s) : Ordentlich A , Barak D , Stein D , Berman D , Kronman C , Ariel N , Velan B , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :234 , 1998
PubMedID:

Title : The Aromatic Moiety at Position-86 of HuAChE Accelerate the Aging of Phosphonyl-AChE Conjugates through Cation- Interactions -
Author(s) : Barak D , Ordentlich A , Stein D , Segall Y , Velan B , Benschop HP , De Jong LP , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :246 , 1998
PubMedID:

Title : ESMS as a Unique Tool for the Molecular Monitoring of Reactions between HuAChE and Various OP-Agents -
Author(s) : Ordentlich A , Barak R , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :249 , 1998
PubMedID:

Title : Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase -
Author(s) : Millard CB , Kryger G , Ordentlich A , Harel M , Raves ML , Greenblatt HM , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL
Ref : In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :425 , 1998
PubMedID:
Gene_locus related to this paper: torca-ACHE

Title : Contribution of Primary Sequence and Post-Translation Modification to the Pharmacokinetics of Human and Bovine Acetylcholinesterases -
Author(s) : Velan B , Kronman C , Chitlaru T , Mendelson I , Ordentlich A , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :291 , 1998
PubMedID:

Title : Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels - Chitlaru_1998_Biochem.J_336_647
Author(s) : Chitlaru T , Kronman C , Zeevi M , Kam M , Harel A , Ordentlich A , Velan B , Shafferman A
Ref : Biochemical Journal , 336 :647 , 1998
Abstract :
PubMedSearch : Chitlaru_1998_Biochem.J_336_647
PubMedID: 9841877

Title : The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors - Ariel_1998_Biochem.J_335_95
Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A
Ref : Biochemical Journal , 335 :95 , 1998
Abstract :
PubMedSearch : Ariel_1998_Biochem.J_335_95
PubMedID: 9742217

Title : 3D Structure at 2.7 Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II -
Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :323 , 1998
PubMedID:

Title : Bovine acetylcholinesterase: cloning, expression and characterization - Mendelson_1998_Biochem.J_334_251
Author(s) : Mendelson I , Kronman C , Ariel N , Shafferman A , Velan B
Ref : Biochemical Journal , 334 :251 , 1998
Abstract :
PubMedSearch : Mendelson_1998_Biochem.J_334_251
PubMedID: 9693127
Gene_locus related to this paper: bovin-ACHE

Title : 3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Resolution -
Author(s) : Kryger G , Giles K , Harel M , Toker L , Velan B , Lazar A , Kronman C , Barak D , Ariel N , Shafferman A , Silman I , Sussman JL
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :370 , 1998
PubMedID:

Title : Compatibility of Structures Inferred from Mutagenesis and from X-Ray Crystallography for Various AChE Complexes -
Author(s) : Ariel N , Ordentlich A , Barak D , Bino T , Velan B , Shafferman A
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :375 , 1998
PubMedID:

Title : Aging of somanyl-acetylcholinesterase adducts: facts and models [letter] -
Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B
Ref : Biochemical Journal , 324 :996 , 1997
PubMedID: 9235881

Title : Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray- ionization mass spectrometry - Barak_1997_FEBS.Lett_407_347
Author(s) : Barak R , Ordentlich A , Barak D , Fischer M , Benschop HP , De Jong LP , Segall Y , Velan B , Shafferman A
Ref : FEBS Letters , 407 :347 , 1997
Abstract :
PubMedSearch : Barak_1997_FEBS.Lett_407_347
PubMedID: 9175882

Title : The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors - Ordentlich_1996_J.Biol.Chem_271_11953
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 271 :11953 , 1996
Abstract :
PubMedSearch : Ordentlich_1996_J.Biol.Chem_271_11953
PubMedID: 8662593

Title : Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives - Grosfeld_1996_Mol.Pharmacol_50_639
Author(s) : Grosfeld H , Barak D , Ordentlich A , Velan B , Shafferman A
Ref : Molecular Pharmacology , 50 :639 , 1996
Abstract :
PubMedSearch : Grosfeld_1996_Mol.Pharmacol_50_639
PubMedID: 8794905

Title : Structural modifications of the omega loop in human acetylcholinesterase - Velan_1996_FEBS.Lett_395_22
Author(s) : Velan B , Barak D , Ariel N , Leitner M , Bino T , Ordentlich A , Shafferman A
Ref : FEBS Letters , 395 :22 , 1996
Abstract :
PubMedSearch : Velan_1996_FEBS.Lett_395_22
PubMedID: 8849682

Title : Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre - Shafferman_1996_Biochem.J_318_833
Author(s) : Shafferman A , Ordentlich A , Barak D , Stein D , Ariel N , Velan B
Ref : Biochemical Journal , 318 :833 , 1996
Abstract :
PubMedSearch : Shafferman_1996_Biochem.J_318_833
PubMedID: 8836126

Title : Denaturation of Recombinant Human Acetylcholinesterase -
Author(s) : Lebleu M , Clery C , Masson P , Reuveny S , Marcus D , Velan B , Shafferman A
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :131 , 1995
PubMedID:

Title : Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase - Ordentlich_1995_J.Biol.Chem_270_2082
Author(s) : Ordentlich A , Barak D , Kronman C , Ariel N , Segall Y , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 270 :2082 , 1995
Abstract :
PubMedSearch : Ordentlich_1995_J.Biol.Chem_270_2082
PubMedID: 7836436

Title : Electrostatic Attraction by Surface Charge does not Contribute to the Catalytic Efficiency of Acetylcholinesterase -
Author(s) : Barak D , Ordentlich A , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B , Shafferman A
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :223 , 1995
PubMedID:

Title : Signal-Mediated Cellular Retention and Subunit Assembly of Human Acetylcholinesterase -
Author(s) : Kronman C , Flashner Y , Shafferman A , Velan B
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :293 , 1995
PubMedID:

Title : Amino Acids Determining Specificity to OP-Agents and Facilitating the Aging Process in Human Acetylcholinesterase -
Author(s) : Ordentlich A , Kronman C , Stein D , Ariel N , Reuveny S , Marcus D , Segall Y , Barak D , Velan B , Shafferman A
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :221 , 1995
PubMedID:

Title : Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite - Barak_1995_Biochemistry_34_15444
Author(s) : Barak D , Ordentlich A , Bromberg A , Kronman C , Marcus D , Lazar A , Ariel N , Velan B , Shafferman A
Ref : Biochemistry , 34 :15444 , 1995
Abstract :
PubMedSearch : Barak_1995_Biochemistry_34_15444
PubMedID: 7492545

Title : Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation - Kronman_1995_Biochem.J_311_959
Author(s) : Kronman C , Velan B , Marcus D , Ordentlich A , Reuveny S , Shafferman A
Ref : Biochemical Journal , 311 :959 , 1995
Abstract :
PubMedSearch : Kronman_1995_Biochem.J_311_959
PubMedID: 7487957

Title : Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases -
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ariel N , Leitner M , Segall Y , Bromberg A , Reuveny S , Marcus D , Bino T , Lazar A , Cohen S , Velan B
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :189 , 1995
PubMedID:

Title : Compilation of Evaluated Mutants of Cholinesterases -
Author(s) : Shafferman A , Kronman C , Ordentlich A
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :481 , 1995
PubMedID:

Title : Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase - Velan_1994_J.Biol.Chem_269_22719
Author(s) : Velan B , Kronman C , Flashner Y , Shafferman A
Ref : Journal of Biological Chemistry , 269 :22719 , 1994
Abstract :
PubMedSearch : Velan_1994_J.Biol.Chem_269_22719
PubMedID: 8077224

Title : Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase - Ashani_1994_Mol.Pharmacol_45_555
Author(s) : Ashani Y , Grunwald J , Kronman C , Velan B , Shafferman A
Ref : Molecular Pharmacology , 45 :555 , 1994
Abstract :
PubMedSearch : Ashani_1994_Mol.Pharmacol_45_555
PubMedID: 8145739
Gene_locus related to this paper: human-ACHE

Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296
Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :6296 , 1994
Abstract :
PubMedSearch : Barak_1994_J.Biol.Chem_269_6296
PubMedID: 8119978

Title : The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis - Kronman_1994_J.Biol.Chem_269_27819
Author(s) : Kronman C , Ordentlich A , Barak D , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :27819 , 1994
Abstract :
PubMedSearch : Kronman_1994_J.Biol.Chem_269_27819
PubMedID: 7961709

Title : Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase - Shafferman_1994_EMBO.J_13_3448
Author(s) : Shafferman A , Ordentlich A , Barak D , Kronman C , Ber R , Bino T , Ariel N , Osman R , Velan B
Ref : EMBO Journal , 13 :3448 , 1994
Abstract :
PubMedSearch : Shafferman_1994_EMBO.J_13_3448
PubMedID: 8062821

Title : Overexpressed monomeric human acetylcholinesterase induces subtle ultrastructural modifications in developing neuromuscular junctions of Xenopus laevis embryos - Seidman_1994_J.Neurochem_62_1670
Author(s) : Seidman S , Aziz-Aloya RB , Timberg R , Loewenstein Y , Velan B , Shafferman A , Liao J , Norgaard-Pedersen B , Brodbeck U , Soreq H
Ref : Journal of Neurochemistry , 62 :1670 , 1994
Abstract :
PubMedSearch : Seidman_1994_J.Neurochem_62_1670
PubMedID: 8158119

Title : Interrelations between assembly and secretion of recombinant human acetylcholinesterase - Kerem_1993_J.Biol.Chem_268_180
Author(s) : Kerem A , Kronman C , Bar-Nun S , Shafferman A , Velan B
Ref : Journal of Biological Chemistry , 268 :180 , 1993
Abstract :
PubMedSearch : Kerem_1993_J.Biol.Chem_268_180
PubMedID: 8416926

Title : Recombinant human acetylcholinesterase - Enzyme engineering -
Author(s) : Shafferman A , Velan B , Barak D , Kronman C , Ordentlich A , Flashner Y , Leitner M , Segal Y , Grosfeld H , Stein D , Ariel N
Ref : Medical Defense Bioscience Review , 3 :1097 , 1993
PubMedID:

Title : N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis - Velan_1993_Biochem.J_296_649
Author(s) : Velan B , Kronman C , Ordentlich A , Flashner Y , Leitner M , Cohen S , Shafferman A
Ref : Biochemical Journal , 296 :649 , 1993
Abstract :
PubMedSearch : Velan_1993_Biochem.J_296_649
PubMedID: 8280063

Title : Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket - Ordentlich_1993_J.Biol.Chem_268_17083
Author(s) : Ordentlich A , Barak D , Kronman C , Flashner Y , Leitner M , Segall Y , Ariel N , Cohen S , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 268 :17083 , 1993
Abstract :
PubMedSearch : Ordentlich_1993_J.Biol.Chem_268_17083
PubMedID: 8349597
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Evaluation of anchorage-dependent cell propagation systems for production of human acetylcholinesterase by recombinant 293 cells - Lazar_1993_Cytotech_13_115
Author(s) : Lazar A , Reuveny S , Kronman C , Velan B , Shafferman A
Ref : Cytotechnology , 13 :115 , 1993
Abstract :
PubMedSearch : Lazar_1993_Cytotech_13_115
PubMedID: 7764576

Title : Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center - Ordentlich_1993_FEBS.Lett_334_215
Author(s) : Ordentlich A , Kronman C , Barak D , Stein D , Ariel N , Marcus D , Velan B , Shafferman A
Ref : FEBS Letters , 334 :215 , 1993
Abstract :
PubMedSearch : Ordentlich_1993_FEBS.Lett_334_215
PubMedID: 8224249

Title : Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center - Shafferman_1992_EMBO.J_11_3561
Author(s) : Shafferman A , Velan B , Ordentlich A , Kronman C , Grosfeld H , Leitner M , Flashner Y , Cohen S , Barak D , Ariel N
Ref : EMBO Journal , 11 :3561 , 1992
Abstract :
PubMedSearch : Shafferman_1992_EMBO.J_11_3561
PubMedID: 1396557

Title : Acetylcholinesterase Catalysis - Protein Engineering Studies -
Author(s) : Shafferman A , Velan B
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :165 , 1992
PubMedID:

Title : Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding - Shafferman_1992_J.Biol.Chem_267_17640
Author(s) : Shafferman A , Kronman C , Flashner Y , Leitner M , Grosfeld H , Ordentlich A , Gozes Y , Cohen S , Ariel N , Barak D , Harel M , Silman I , Sussman JL , Velan B
Ref : Journal of Biological Chemistry , 267 :17640 , 1992
Abstract :
PubMedSearch : Shafferman_1992_J.Biol.Chem_267_17640
PubMedID: 1517212

Title : Production and secretion of high levels of recombinant human acetylcholinesterase in cultured cell lines: microheterogeneity of the catalytic subunit - Kronman_1992_Gene_121_295
Author(s) : Kronman C , Velan B , Gozes Y , Leitner M , Flashner Y , Lazar A , Marcus D , Sery T , Papier Y , Grosfeld H , Cohen S , Shafferman A
Ref : Gene , 121 :295 , 1992
Abstract :
PubMedSearch : Kronman_1992_Gene_121_295
PubMedID: 1446827

Title : The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant - Velan_1991_J.Biol.Chem_266_23977
Author(s) : Velan B , Grosfeld H , Kronman C , Leitner M , Gozes Y , Lazar A , Flashner Y , Marcus D , Cohen S , Shafferman A
Ref : Journal of Biological Chemistry , 266 :23977 , 1991
Abstract :
PubMedSearch : Velan_1991_J.Biol.Chem_266_23977
PubMedID: 1748670

Title : Recombinant human acetylcholinesterase is secreted from transiently transfected 293 cells as a soluble globular enzyme - Velan_1991_Cell.Mol.Neurobiol_11_143
Author(s) : Velan B , Kronman C , Grosfeld H , Leitner M , Gozes Y , Flashner Y , Sery T , Cohen S , Ben-Aziz R , Seidman S , Shafferman A , Soreq H
Ref : Cellular Molecular Neurobiology , 11 :143 , 1991
Abstract :
PubMedSearch : Velan_1991_Cell.Mol.Neurobiol_11_143
PubMedID: 1849451

Title : Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells - Cohen_1985_Dev.Biol.Stand_60_111
Author(s) : Cohen S , Velan B , Grosfeld H , Shalita Z , Leitner M , Shafferman A
Ref : Developmental Biology Stand , 60 :111 , 1985
Abstract :
PubMedSearch : Cohen_1985_Dev.Biol.Stand_60_111
PubMedID: 2995168

Title : Cloning of a bovine interferon-alpha gene subfamily and comparisons between genetically engineered and leukocyte bovine interferons - Velan_1985_Dev.Biol.Stand_60_355
Author(s) : Velan B , Cohen S , Grosfeld H , Shalita Z , Shafferman A
Ref : Developmental Biology Stand , 60 :355 , 1985
Abstract :
PubMedSearch : Velan_1985_Dev.Biol.Stand_60_355
PubMedID: 3899795

Title : Mutations not altering the symmetrical sequences in the trp operator yield a constitutive phenotype - Grosfeld_1984_Mol.Gen.Genet_195_358
Author(s) : Grosfeld H , Cohen S , Velan B , Shalita Z , Shafferman A
Ref : Molecular & General Genetics , 195 :358 , 1984
Abstract :
PubMedSearch : Grosfeld_1984_Mol.Gen.Genet_195_358
PubMedID: 6092859