Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : OP-resistance increases Km towards BChE and IC50 for iso-OMPA Gnatt_1994_J.Neurochem_62_749
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : OP-resistance
Torpedo_number : 442
Kinetic Parameter : Butyrylthiocholine_Y440D_human-BCHE, Echothiophate_Y440D_human-BCHE, Iso-OMPA_Y440D_human-BCHE, DFP_Y440D_human-BCHE
News : No news
Comment :
p.Y440D Tyr440Asp (p.Y468D Tyr468Asp in primary sequence with 28 amino-acids signal peptide) OP-resistance\; increases Km towards BChE and IC50 for iso-OMPA
| Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749 |
| Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H |
| Ref : Journal of Neurochemistry , 62 :749 , 1994 |
| Abstract : |
| PubMedSearch : Gnatt_1994_J.Neurochem_62_749 |
| PubMedID: 8294937 |