Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Acyl specificity replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE Kaplan_2001_Biochemistry_40_7433
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Acyl specificity
Torpedo_number : 70
Kinetic Parameter : Acetylthiocholine_Y72N_human-ACHE, Butyrylthiocholine_Y72N_human-ACHE
News : No news
Comment :
p.Y72N Tyr72Asn (p.103N Tyr103Asn in primary sequence with 31 amino-acids signal peptide) Acyl specificity\;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE
| Title : Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? - Kaplan_2001_Biochemistry_40_7433 |
| Author(s) : Kaplan D , Ordentlich A , Barak D , Ariel N , Kronman C , Velan B , Shafferman A |
| Ref : Biochemistry , 40 :7433 , 2001 |
| Abstract : |
| PubMedSearch : Kaplan_2001_Biochemistry_40_7433 |
| PubMedID: 11412096 |