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Mutation Report for: D70K_human-BCHE

Mode of mutation|Site directed mutagenesis
Amino Acid change|D70K
Torpedo number|72
Comment|p.D70K Asp70Lys (p.D98K Asp98Lys in primary sequence with 28 amino-acids signal peptide) Higher Km
Kinetic parameters|none

    Title: Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters
    Masson P, Froment MT, Fortier PL, Visicchio JE, Bartels CF, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1387:41, 1998 : PubMed


    Title: Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase
    Masson P, Legrand P, Bartels CF, Froment MT, Schopfer LM, Lockridge O
    Ref: Biochemistry, 36:2266, 1997 : PubMed


    Title: Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase
    Masson P, Froment MT, Bartels CF, Lockridge O
    Ref: Biochemical Journal, 325:53, 1997 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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