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Mutation Report for: F362Y_lepsm-ACHE1A

Mode of mutation|Natural mutant
Amino Acid change|F362Y
Torpedo number|331
Comment|Mutation found in one of the two copies of ace1 in this species of copepod. It could play a role in azamethiphos sensivity. The position is 362 in the protein corresponding to 331 in Torpedo. The mutation pre-dates organophosphate use in salmon farming
Kinetic parameters|none

    Title: The mechanism (Phe362Tyr mutation) behind resistance in Lepeophtheirus salmonis pre-dates organophosphate use in salmon farming
    Kaur K, Besnier F, Glover KA, Nilsen F, Aspehaug VT, Fjortoft HB, Horsberg TE
    Ref: Sci Rep, 7:12349, 2017 : PubMed


    Title: Phe362Tyr in AChE: A Major Factor Responsible for Azamethiphos Resistance in Lepeophtheirus salmonis in Norway
    Kaur K, Jansen PA, Aspehaug VT, Horsberg TE
    Ref: PLoS ONE, 11:e0149264, 2016 : PubMed


    Title: Mechanism behind Resistance against the Organophosphate Azamethiphos in Salmon Lice (Lepeophtheirus salmonis)
    Kaur K, Helgesen KO, Bakke MJ, Horsberg TE
    Ref: PLoS ONE, 10:e0124220, 2015 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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