Title : Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo - Bajgar_2010_Chem.Biol.Interact_187_287 |
Author(s) : Bajgar J , Karasova JZ , Kassa J , Cabal J , Fusek J , Blaha V , Tesarova S |
Ref : Chemico-Biological Interactions , 187 :287 , 2010 |
Abstract :
Up to now, intensive attempts to synthesize a universal reactivator able to reactivate cholinesterases inhibited by all types of nerve agents/organophosphates were not successful. Therefore, another approach using a combination of two reactivators differently reactivating enzyme was used: in rats poisoned with tabun and treated with combination of atropine (fixed dose) and different doses of trimedoxime and HI-6, changes of acetylcholinesterase activities (blood, diaphragm and different parts of the brain) were studied. An increase of AChE activity was observed following trimedoxime treatment depending on its dose; HI-6 had very low effect. Combination of both oximes showed potentiation of their reactivation efficacy; this potentiation was expressed for peripheral AChE (blood, diaphragm) and some parts of the brain (pontomedullar area, frontal cortex); AChE in the basal ganglia was relatively resistant. These observations suggest that the action of combination of oximes in vivo is different from that observed in vitro. |
PubMedSearch : Bajgar_2010_Chem.Biol.Interact_187_287 |
PubMedID: 20167212 |
Reactivator | Trimedoxime |
Bajgar J, Karasova JZ, Kassa J, Cabal J, Fusek J, Blaha V, Tesarova S (2010)
Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo
Chemico-Biological Interactions
187 :287
Bajgar J, Karasova JZ, Kassa J, Cabal J, Fusek J, Blaha V, Tesarova S (2010)
Chemico-Biological Interactions
187 :287