Karasova JZ

General

Full name : Zdarova Karasova Jana

First name : Jana

Mail : Faculty of Military Health Sciences\; Department of Public Health\; Trebesska 1575\; Hradec Kralove\; 50001

Zip Code :

City :

Country : Czech Republic

Email : karasova@pmfhk.cz

Phone : +42097325312

Fax :

Website :

Directory :

References (71)

Title : Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents - Prchalova_2024_Arch.Toxicol__
Author(s) : Prchalova E , Andrys R , Pejchal J , Kohoutova Z , Knittelova K , Hofmanova T , Skarka A , Dlabkova A , Psotka M , Prchal L , Musilek K , Karasova JZ , Malinak D
Ref : Archives of Toxicology , : , 2024
Abstract :
PubMedSearch : Prchalova_2024_Arch.Toxicol__
PubMedID: 38789714

Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130
Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O
Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024
Abstract :
PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130
PubMedID: 38218127

Title : Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice - Kassa_2023_Toxicol.Mech.Methods__1
Author(s) : Kassa J , Karasova JZ
Ref : Toxicol Mech Methods , :1 , 2023
Abstract :
PubMedSearch : Kassa_2023_Toxicol.Mech.Methods__1
PubMedID: 37051629

Title : The measured CSF\/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease - Valis_2023_Biomed.Pharmacother_159_114223
Author(s) : Valis M , Dlabkova A , Hort J , Angelucci F , Pejchal J , Kuca K , Pavelek Z , Karasova JZ , Novotny M
Ref : Biomed Pharmacother , 159 :114223 , 2023
Abstract :
PubMedSearch : Valis_2023_Biomed.Pharmacother_159_114223
PubMedID: 36630846

Title : The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs - Tsianou_2023_PLoS.One_18_e0286386
Author(s) : Tsianou CC , Kvetina J , Radochova V , Kohoutova D , Rejchrt S , Valis M , Karasova JZ , Tacheci I , Knoblochova V , Soukup O , Bures J
Ref : PLoS ONE , 18 :e0286386 , 2023
Abstract :
PubMedSearch : Tsianou_2023_PLoS.One_18_e0286386
PubMedID: 37262057

Title : Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870 - Karasova_2022_Food.Chem.Toxicol__113236
Author(s) : Karasova JZ , Kassa J , Hepnarova V , Pejchal J , Junova L , Andrys R , Malinak D , Bzonek P , Kohoutova Z , Musilek K
Ref : Food & Chemical Toxicology , :113236 , 2022
Abstract :
PubMedSearch : Karasova_2022_Food.Chem.Toxicol__113236
PubMedID: 35738326

Title : Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors - Gorecki_2021_Eur.J.Med.Chem_219_113434
Author(s) : Gorecki L , Misiachna A , Damborsky J , Dolezal R , Korabecny J , Cejkova L , Hakenova K , Chvojkova M , Karasova JZ , Prchal L , Novak M , Kolcheva M , Kortus S , Vales K , Horak M , Soukup O
Ref : Eur Journal of Medicinal Chemistry , 219 :113434 , 2021
Abstract :
PubMedSearch : Gorecki_2021_Eur.J.Med.Chem_219_113434
PubMedID: 33892271

Title : A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats - Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145
Author(s) : Kassa J , Hatlapatkova J , Karasova JZ , Hepnarova V , Caisberger F , Pejchal J
Ref : Acta Medica (Hradec Kralove) , 64 :145 , 2021
Abstract :
PubMedSearch : Kassa_2021_Acta.Medica.(Hradec.Kralove)_64_145
PubMedID: 34779379

Title : Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs - Bures_2021_Pharmaceuticals.(Basel)_14_
Author(s) : Bures J , Tacheci I , Kvetina J , Radochova V , Kohoutova D , Valis M , Rejchrt S , Knoblochova V , Karasova JZ
Ref : Pharmaceuticals (Basel) , 14 : , 2021
Abstract :
PubMedSearch : Bures_2021_Pharmaceuticals.(Basel)_14_
PubMedID: 34207410

Title : Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study - Vanova_2021_J.Pharm.Sci__
Author(s) : Vanova N , Hojna A , Pejchal J , Herman D , Malinak D , Prchalova E , Musilek K , Karasova JZ
Ref : J Pharm Sci , : , 2021
Abstract :
PubMedSearch : Vanova_2021_J.Pharm.Sci__
PubMedID: 33545185

Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__
Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J
Ref : Archives of Toxicology , : , 2021
Abstract :
PubMedSearch : Gorecki_2021_Arch.Toxicol__
PubMedID: 33517499

Title : Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry - Andrys_2021_Mol.Pharm__
Author(s) : Andrys R , Klusonova A , Lisa M , Kassa J , Karasova JZ
Ref : Mol Pharm , : , 2021
Abstract :
PubMedSearch : Andrys_2021_Mol.Pharm__
PubMedID: 34019427

Title : Memantine and Its Combination with Acetylcholinesterase Inhibitors in Pharmacological Pretreatment of Soman Poisoning in Mice - Kassa_2021_Neurotox.Res__
Author(s) : Kassa J , Karasova JZ
Ref : Neurotox Res , : , 2021
Abstract :
PubMedSearch : Kassa_2021_Neurotox.Res__
PubMedID: 34292503

Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__
Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML
Ref : ACS Chem Neurosci , : , 2021
Abstract :
PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__
PubMedID: 33852284

Title : Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats - Karasova_2020_Iran.J.Pharm.Res_19_95
Author(s) : Karasova JZ , Hrabinova M , Krejciova M , Jun D , Kuca K
Ref : Iran J Pharm Res , 19 :95 , 2020
Abstract :
PubMedSearch : Karasova_2020_Iran.J.Pharm.Res_19_95
PubMedID: 33680013

Title : Interaction of Cucurbit[7]uril with Oxime K027, Atropine, and Paraoxon: Risky or Advantageous Delivery System? - Karasova_2020_Int.J.Mol.Sci_21_
Author(s) : Karasova JZ , Mzik M , Kucera T , Vecera Z , Kassa J , Sestak V
Ref : Int J Mol Sci , 21 : , 2020
Abstract :
PubMedSearch : Karasova_2020_Int.J.Mol.Sci_21_
PubMedID: 33114215

Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64
Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K
Ref : Toxicol Lett , 320 :64 , 2020
Abstract :
PubMedSearch : Karasova_2020_Toxicol.Lett_320_64
PubMedID: 31794810

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
Abstract :
PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1
Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K
Ref : Drug & Chemical Toxicology , :1 , 2019
Abstract :
PubMedSearch : Karasova_2019_Drug.Chem.Toxicol__1
PubMedID: 31257938

Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K
Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018
Abstract :
PubMedSearch : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
PubMedID: 29067789

Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018
Abstract :
PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8
PubMedID: 29467029

Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K
Ref : Drug Des Devel Ther , 12 :505 , 2018
Abstract :
PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505
PubMedID: 29563775

Title : Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis - Karasova_2017_Toxicol.Lett_277_24
Author(s) : Karasova JZ , Maderycova Z , Tumova M , Jun D , Rehacek V , Kuca K , Misik J
Ref : Toxicol Lett , 277 :24 , 2017
Abstract :
PubMedSearch : Karasova_2017_Toxicol.Lett_277_24
PubMedID: 28465191

Title : The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203 - Kassa_2017_Molecules_22_
Author(s) : Kassa J , Misik J , Hatlapatkova J , Karasova JZ , Sepsova V , Caisberger F , Pejchal J
Ref : Molecules , 22 : , 2017
Abstract :
PubMedSearch : Kassa_2017_Molecules_22_
PubMedID: 28696367

Title : A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats - Kassa_2017_Toxicol.Mech.Methods__1
Author(s) : Kassa J , Misik J , Hatlapatkova J , Karasova JZ
Ref : Toxicol Mech Methods , :1 , 2017
Abstract :
PubMedSearch : Kassa_2017_Toxicol.Mech.Methods__1
PubMedID: 28043192

Title : Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs - Karasova_2017_Toxicol.Lett_273_20
Author(s) : Karasova JZ , Kvetina J , Tacheci I , Radochova V , Musilek K , Kuca K , Bures J
Ref : Toxicol Lett , 273 :20 , 2017
Abstract :
PubMedSearch : Karasova_2017_Toxicol.Lett_273_20
PubMedID: 28343895

Title : Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity - Karasova_2016_Neurotox.Res_29_267
Author(s) : Karasova JZ , Hroch M , Musilek K , Kuca K
Ref : Neurotox Res , 29 :267 , 2016
Abstract :
PubMedSearch : Karasova_2016_Neurotox.Res_29_267
PubMedID: 26646154

Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016
Abstract :
PubMedSearch : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
PubMedID: 27030895

Title : Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning - Katalinic_2015_Arh.Hig.Rada.Toksikol_66_291
Author(s) : Katalinic M , Macek Hrvat N , Karasova JZ , Misik J , Kovarik Z
Ref : Arh Hig Rada Toksikol , 66 :291 , 2015
Abstract :
PubMedSearch : Katalinic_2015_Arh.Hig.Rada.Toksikol_66_291
PubMedID: 26751861

Title : The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats - Kassa_2015_Acta.Medica.(Hradec.Kralove)_58_135
Author(s) : Kassa J , Hatlapatkova J , Karasova JZ
Ref : Acta Medica (Hradec Kralove) , 58 :135 , 2015
Abstract :
PubMedSearch : Kassa_2015_Acta.Medica.(Hradec.Kralove)_58_135
PubMedID: 26960827

Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189
Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O
Ref : Gen Physiol Biophys , 34 :189 , 2015
Abstract :
PubMedSearch : Sepsova_2015_Gen.Physiol.Biophys_34_189
PubMedID: 25504063

Title : HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs - Kunes_2014_Neuro.Endocrinol.Lett_35_186
Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K
Ref : Neuro Endocrinol Lett , 35 :186 , 2014
Abstract :
PubMedSearch : Kunes_2014_Neuro.Endocrinol.Lett_35_186
PubMedID: 25638385

Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771
Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O
Ref : Physiol Res , 63 :771 , 2014
Abstract :
PubMedSearch : Sepsova_2014_Physiol.Res_63_771
PubMedID: 25157661

Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74
Author(s) : Karasova JZ , Zemek F , Kunes M , Kvetina J , Chladek J , Jun D , Bures J , Tacheci I , Kuca K
Ref : Neuro Endocrinol Lett , 34 :74 , 2013
Abstract :
PubMedSearch : Karasova_2013_Neuro.Endocrinol.Lett_34_74
PubMedID: 24362096

Title : Transdermal penetration of the acetylcholinesterase reactivator HI-6 in a rat model - Kracmarova_2013_Mil.Med.Sci.Lett_82_185
Author(s) : Kracmarova A , Bartosova L , Karasova JZ , Zemek F , Bajgar J
Ref : Military Medical Science Letters , 82 :185 , 2013
Abstract :
PubMedSearch : Kracmarova_2013_Mil.Med.Sci.Lett_82_185
PubMedID:

Title : Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats - Kassa_2013_Basic.Clin.Pharmacol.Toxicol_113_201
Author(s) : Kassa J , Misik J , Karasova JZ
Ref : Basic Clin Pharmacol Toxicol , 113 :201 , 2013
Abstract :
PubMedSearch : Kassa_2013_Basic.Clin.Pharmacol.Toxicol_113_201
PubMedID: 23647829

Title : Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma - Karasova_2013_J.Appl.Toxicol_33_18
Author(s) : Karasova JZ , Chladek J , Hroch M , Josef F , Hnidkova D , Kuca K
Ref : J Appl Toxicol , 33 :18 , 2013
Abstract :
PubMedSearch : Karasova_2013_J.Appl.Toxicol_33_18
PubMedID: 21717485

Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893
Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K
Ref : Curr Alzheimer Res , 10 :893 , 2013
Abstract :
PubMedSearch : Soukup_2013_Curr.Alzheimer.Res_10_893
PubMedID: 24093535

Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102
Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O
Ref : Mini Rev Med Chem , 13 :2102 , 2013
Abstract :
PubMedSearch : Kuca_2013_Mini.Rev.Med.Chem_13_2102
PubMedID: 24195661

Title : Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study - Sepsova_2013_Int.J.Mol.Sci_14_16882
Author(s) : Sepsova V , Karasova JZ , Korabecny J , Dolezal R , Zemek F , Bennion BJ , Kuca K
Ref : Int J Mol Sci , 14 :16882 , 2013
Abstract :
PubMedSearch : Sepsova_2013_Int.J.Mol.Sci_14_16882
PubMedID: 23959117

Title : Combined approach to demonstrate acetylcholinesterase activity changes in the rat brain following tabun intoxication and its treatment - Bajgar_2012_Toxicol.Mech.Methods_22_60
Author(s) : Bajgar J , Hajek P , Kassa J , Slizova D , Krs O , Karasova JZ , Fusek J , Capek L , Voicu VA
Ref : Toxicol Mech Methods , 22 :60 , 2012
Abstract :
PubMedSearch : Bajgar_2012_Toxicol.Mech.Methods_22_60
PubMedID: 21851296

Title : The ability of oxime mixtures to increase the reactivating and therapeutic efficacy of antidotal treatment of cyclosarin poisoning in rats and mice - Kassa_2012_Acta.Medica.(Hradec.Kralove)_55_27
Author(s) : Kassa J , Karasova JZ , Pavlikova R , Caisberger F , Bajgar J
Ref : Acta Medica (Hradec Kralove) , 55 :27 , 2012
Abstract :
PubMedSearch : Kassa_2012_Acta.Medica.(Hradec.Kralove)_55_27
PubMedID: 22696932

Title : Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings - Kassa_2012_Mini.Rev.Med.Chem_12_24
Author(s) : Kassa J , Musilek K , Karasova JZ , Kuca K , Bajgar J
Ref : Mini Rev Med Chem , 12 :24 , 2012
Abstract :
PubMedSearch : Kassa_2012_Mini.Rev.Med.Chem_12_24
PubMedID: 22360668

Title : Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study - Sepsova_2011_Mil.Med.Sci.Lett_80_178
Author(s) : Sepsova V , Karasova JZ , Zemek F , Bennion BJ , Kuca K
Ref : Military Medical Science Letters , 80 :178 , 2011
Abstract :
PubMedSearch : Sepsova_2011_Mil.Med.Sci.Lett_80_178
PubMedID:

Title : Method optimization for acetylcholinesterase modulators-albumin interactions - Zemek_2011_Mil.Med.Sci.Lett_80_58
Author(s) : Zemek F , Karasova JZ , Musilek K , Kuca K
Ref : Military Medical Science Letters , 80 :58 , 2011
Abstract :
PubMedSearch : Zemek_2011_Mil.Med.Sci.Lett_80_58
PubMedID:

Title : The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice - Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30
Author(s) : Kassa J , Karasova JZ , Sepsova V , Caisberger F
Ref : Basic Clin Pharmacol Toxicol , 109 :30 , 2011
Abstract :
PubMedSearch : Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30
PubMedID: 21235715

Title : A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice - Kassa_2011_Int.J.Toxicol_30_562
Author(s) : Kassa J , Karasova JZ , Sepsova V , Caisberger F , Bajgar J
Ref : Int J Toxicol , 30 :562 , 2011
Abstract :
PubMedSearch : Kassa_2011_Int.J.Toxicol_30_562
PubMedID: 22013137

Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97
Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J
Ref : Military Medical Science Letters , 80 :97 , 2011
Abstract :
PubMedSearch : Karasova_2011_Mil.Med.Sci.Lett_80_97
PubMedID:

Title : Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain - Karasova_2011_J.Pharm.Biomed.Anal_54_1082
Author(s) : Karasova JZ , Zemek F , Bajgar J , Vasatova M , Prochazka P , Novotny L , Kuca K
Ref : J Pharm Biomed Anal , 54 :1082 , 2011
Abstract :
PubMedSearch : Karasova_2011_J.Pharm.Biomed.Anal_54_1082
PubMedID: 21146949

Title : Colorimetric Detectors Based on Acetylcholinesterase and Its Construction - Pohanka_2010_Mil.Med.Sci.Lett_79_9
Author(s) : Pohanka M , Vlcek V , Karasova JZ , Kuca K , Cabal J
Ref : Military Medical Science Letters , 79 :9 , 2010
Abstract :
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_9
PubMedID:

Title : Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates. - Pohanka_2010_Mil.Med.Sci.Lett_79_105
Author(s) : Pohanka M , Drobik O , Krenkova Z , Karasova JZ , Cabal J , Kuca K
Ref : Military Medical Science Letters , 79 :105 , 2010
Abstract :
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_105
PubMedID:

Title : Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy. - Pohanka_2010_Mil.Med.Sci.Lett_79_111
Author(s) : Pohanka M , Hrabinova M , Karasova JZ , Holas O , Kuca K , Cabal J
Ref : Military Medical Science Letters , 79 :111 , 2010
Abstract :
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_111
PubMedID:

Title : New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning - Pavlikova_2010_Mil.Med.Sci.Lett_79_46
Author(s) : Pavlikova R , Marek J , Musilek K , Fusek J , Kuca K , Karasova JZ
Ref : Military Medical Science Letters , 79 :46 , 2010
Abstract :
PubMedSearch : Pavlikova_2010_Mil.Med.Sci.Lett_79_46
PubMedID:

Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L
Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010
Abstract :
PubMedSearch : Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
PubMedID: 21054236

Title : Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System? - Karasova_2010_Mil.Med.Sci.Lett_79_23
Author(s) : Karasova JZ , Kassa J , Musilek K , Jung Y , Kuca K
Ref : Military Medical Science Letters , 79 :23 , 2010
Abstract :
PubMedSearch : Karasova_2010_Mil.Med.Sci.Lett_79_23
PubMedID:

Title : Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX - Pohanka_2010_Talanta_81_621
Author(s) : Pohanka M , Karasova JZ , Kuca K , Pikula J , Holas O , Korabecny J , Cabal J
Ref : Talanta , 81 :621 , 2010
Abstract :
PubMedSearch : Pohanka_2010_Talanta_81_621
PubMedID: 20188972

Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63
Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K
Ref : Anal Sci , 26 :63 , 2010
Abstract :
PubMedSearch : Karasova_2010_Anal.Sci_26_63
PubMedID: 20065589

Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS
Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010
Abstract :
PubMedSearch : Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
PubMedID: 22545968

Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS
Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010
Abstract :
PubMedSearch : Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
PubMedID: 20233085

Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure - Karasova_2010_Toxicol.In.Vitro_24_1838
Author(s) : Karasova JZ , Pohanka M , Musilek K , Zemek F , Kuca K
Ref : Toxicol In Vitro , 24 :1838 , 2010
Abstract :
PubMedSearch : Karasova_2010_Toxicol.In.Vitro_24_1838
PubMedID: 20546883

Title : The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice - Kassa_2010_J.Appl.Toxicol_30_120
Author(s) : Kassa J , Karasova JZ , Pavlikova R , Misik J , Caisberger F , Bajgar J
Ref : J Appl Toxicol , 30 :120 , 2010
Abstract :
PubMedSearch : Kassa_2010_J.Appl.Toxicol_30_120
PubMedID: 19746406

Title : Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo - Bajgar_2010_Chem.Biol.Interact_187_287
Author(s) : Bajgar J , Karasova JZ , Kassa J , Cabal J , Fusek J , Blaha V , Tesarova S
Ref : Chemico-Biological Interactions , 187 :287 , 2010
Abstract :
PubMedSearch : Bajgar_2010_Chem.Biol.Interact_187_287
PubMedID: 20167212

Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227
Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K
Ref : Drug & Chemical Toxicology , 33 :227 , 2010
Abstract :
PubMedSearch : Kassa_2010_Drug.Chem.Toxicol_33_227
PubMedID: 20429807

Title : Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy - Pohanka_2009_J.Appl.Toxicol_29_483
Author(s) : Pohanka M , Karasova JZ , Musilek K , Kuca K , Kassa J
Ref : J Appl Toxicol , 29 :483 , 2009
Abstract :
PubMedSearch : Pohanka_2009_J.Appl.Toxicol_29_483
PubMedID: 19338015

Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K
Ref : Toxicol Mech Methods , 19 :346 , 2009
Abstract :
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_346
PubMedID: 19778210

Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356
Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K
Ref : Neurotox Res , 16 :356 , 2009
Abstract :
PubMedSearch : Karasova_2009_Neurotox.Res_16_356
PubMedID: 19728005

Title : Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats - Karasova_2009_Int.J.Mol.Sci_10_3065
Author(s) : Karasova JZ , Kassa J , Musilek K , Pohanka M , Novotny L , Kuca K
Ref : Int J Mol Sci , 10 :3065 , 2009
Abstract :
PubMedSearch : Karasova_2009_Int.J.Mol.Sci_10_3065
PubMedID: 19742125

Title : The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_547
Author(s) : Kassa J , Karasova JZ , Caisberger F , Bajgar J
Ref : Toxicol Mech Methods , 19 :547 , 2009
Abstract :
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_547
PubMedID: 19839724

Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY
Ref : Toxicol Mech Methods , 19 :232 , 2009
Abstract :
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_232
PubMedID: 19730756

Title : Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon - Kuca_2009_Molecules_14_4915
Author(s) : Kuca K , Musilova L , Palecek J , Cirkva V , Paar M , Musilek K , Hrabinova M , Pohanka M , Karasova JZ , Jun D
Ref : Molecules , 14 :4915 , 2009
Abstract :
PubMedSearch : Kuca_2009_Molecules_14_4915
PubMedID: 20032868

Title : Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats - Karasova_2008_Int.J.Mol.Sci_9_2243
Author(s) : Karasova JZ , Kassa J , Jung YS , Musilek K , Pohanka M , Kuca K
Ref : Int J Mol Sci , 9 :2243 , 2008
Abstract :
PubMedSearch : Karasova_2008_Int.J.Mol.Sci_9_2243
PubMedID: 19330072