Abaci_2023_Int.J.Environ.Health.Res__1

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Title : In vitro and in silico cholinesterase inhibitory and antioxidant effects of essential oils and extracts of two new Salvia fruticosa mill. cultivars (Turgut and Uysal) and GC-MS analysis of the essential oils - Abaci_2023_Int.J.Environ.Health.Res__1
Author(s) : Abaci N , Senol Deniz FS , Ekhteiari Salmas R , Uysal Bayar F , Turgut K , Orhan IE
Ref : Int J Environ Health Res , :1 , 2023
Abstract : The EtOH extracts of the leaves of two new cultivars (Uysal-SFU and Turgut-SFT) of Salvia fruticosa Mill. was tested against acetylcholinesterase (IC50: 30.62 +/- 3.27 and 32.97 +/- 2.33 microg/mL for SFU and SFT, respectively) and butyrylcholinesterase (IC50: 69.91 +/- 1.08 microg/mL and 86.55 +/- 1.26 microg/mL), respectively, relevant to Alzheimer's disease. The essential oils showed a stumpy inhibition against AChE and no inhibition against BChE. DPPH radical scavenging activity of the extracts (86.70 +/- 0.17% and 86.14 +/- 1.13% for SFU and SFT, respectively) was stronger than that of quercetin (85.51 +/- 0.17%): Their (1.24 +/- 0.05 and 1.04 +/- 0.16 for SFU and SFT, respectively) ferric-reducing antioxidant power were close to that of the reference (e.g. quercetin, 1.42 +/- 0.14). Molecular docking simulations were performed on their major monoterpenes. Our findings revealed that the leaf EtOH extracts of two cultivars are promising inhibitors of both AChE and BChE.
ESTHER : Abaci_2023_Int.J.Environ.Health.Res__1
PubMedSearch : Abaci_2023_Int.J.Environ.Health.Res__1
PubMedID: 36739545

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Citations formats

Abaci N, Senol Deniz FS, Ekhteiari Salmas R, Uysal Bayar F, Turgut K, Orhan IE (2023)
In vitro and in silico cholinesterase inhibitory and antioxidant effects of essential oils and extracts of two new Salvia fruticosa mill. cultivars (Turgut and Uysal) and GC-MS analysis of the essential oils
Int J Environ Health Res :1

Abaci N, Senol Deniz FS, Ekhteiari Salmas R, Uysal Bayar F, Turgut K, Orhan IE (2023)
Int J Environ Health Res :1