Abdel Moneim_2012_Biol.Trace.Elem.Res_148_363

Reference

Title : Flaxseed oil as a neuroprotective agent on lead acetate-induced monoamineric alterations and neurotoxicity in rats - Abdel Moneim_2012_Biol.Trace.Elem.Res_148_363
Author(s) : Abdel Moneim AE
Ref : Biol Trace Elem Res , 148 :363 , 2012
Abstract :

Lead remains a considerable occupational and public health problem, which is known to cause a number of adverse effects in both man and animals. Here, the neuroprotective effect of flaxseed oil (1,000 mg/kg) on lead acetate (20 mg/kg) induced alternation in monoamines and brain oxidative stress was examined in rats. The levels of lead, dopamine (DA), norepinephrine (NE), serotonin (5-HT), lipid peroxidation, nitrite/nitrate (NO), and glutathione (GSH) were determined; also, the activity of acetylcholinesterase (AChE) and Na(+)-K(+)-ATPase were estimated on different brain regions of adult male albino rats. The level of lead was markedly elevated in different brain regions of rats. This leads to enhancement of lipid peroxidation and NO production in brain with concomitant reduction in AChE activity and GSH level. In addition, the levels of DA, NE, and 5-HT were decreased in the brain. These findings were associated with BAX over expression. Treatment of rats with flaxseed oil induced a marked improvement in most of the studied parameters as well as the immunohistochemistry features. These data indicated that dietary flaxseed oil provide protection against lead-induced oxidative stress and neurotoxic effects.

PubMedSearch : Abdel Moneim_2012_Biol.Trace.Elem.Res_148_363
PubMedID: 22395955

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Citations formats

Abdel Moneim AE (2012)
Flaxseed oil as a neuroprotective agent on lead acetate-induced monoamineric alterations and neurotoxicity in rats
Biol Trace Elem Res 148 :363

Abdel Moneim AE (2012)
Biol Trace Elem Res 148 :363