| Title : A role for lysosomal phospholipase A2 in drug induced phospholipidosis - Abe_2007_Drug.Metab.Lett_1_49 |
| Author(s) : Abe A , Hiraoka M , Shayman JA |
| Ref : Drug Metab Lett , 1 :49 , 2007 |
|
Abstract :
Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity. |
| PubMedSearch : Abe_2007_Drug.Metab.Lett_1_49 |
| PubMedID: 19356018 |
Abe A, Hiraoka M, Shayman JA (2007)
A role for lysosomal phospholipase A2 in drug induced phospholipidosis
Drug Metab Lett
1 :49
Abe A, Hiraoka M, Shayman JA (2007)
Drug Metab Lett
1 :49