Title : A molecular approach in drug development for Alzheimer's disease - Agatonovic-Kustrin_2018_Biomed.Pharmacother_106_553
Author(s) : Agatonovic-Kustrin S , Kettle C , Morton DW
Ref : Biomed Pharmacother , 106 :553 , 2018
Abstract :

An increase in dementia numbers and global trends in population aging across the world prompts the need for new medications to treat the complex biological dysfunctions, such as neurodegeneration associated with dementia. Alzheimer's disease (AD) is the most common form of dementia. Cholinergic signaling, which is important in cognition, is slowly lost in AD, so the first line therapy is to treat symptoms with acetylcholinesterase inhibitors to increase levels of acetylcholine. Out of five available FDA-approved AD medications, donepezil, galantamine and rivastigmine are cholinesterase inhibitors while memantine, a N-methyl d-aspartate (NMDA) receptor antagonist, blocks the effects of high glutamate levels. The fifth medication consists of a combination of donepezil and memantine. Although these medications can reduce and temporarily slow down the symptoms of AD, they cannot stop the damage to the brain from progressing. For a superior therapeutic effect, multi-target drugs are required. Thus, a Multi-Target-Directed Ligand (MTDL) strategy has received more attention by scientists who are attempting to develop hybrid molecules that simultaneously modulate multiple biological targets. This review highlights recent examples of the MTDL approach and fragment based strategy in the rational design of new potential AD medications.

PubMedSearch : Agatonovic-Kustrin_2018_Biomed.Pharmacother_106_553
PubMedID: 29990843

Related information

Citations formats

Agatonovic-Kustrin S, Kettle C, Morton DW (2018)
A molecular approach in drug development for Alzheimer's disease
Biomed Pharmacother 106 :553

Agatonovic-Kustrin S, Kettle C, Morton DW (2018)
Biomed Pharmacother 106 :553