Title : Effect of the beta 2-adrenergic agonist clenbuterol on the growth of fast- and slow-twitch skeletal muscle of the dystrophic (C57BL6J dy2J\/dy2J) mouse - Agbenyega_1995_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_111_397 |
Author(s) : Agbenyega ET , Morton RH , Hatton PA , Wareham AC |
Ref : Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology , 111 :397 , 1995 |
Abstract :
Clenbuterol (4mg/kg in diet for 21 days) had no statistically significant effect on whole body growth. It did cause a significant increase (18.2%) in wet weight of the fast twitch muscle extensor digitorum longus (EDL) and a corresponding 14.9% increase in total muscle protein. In transverse sections through dystrophic muscle fibre sizes were more variable than in normal muscle. Clenbuterol treatment resulted in a reduction in the proportion of small diameter fibres, and therefore an increase in mean fibre diameter, in dystrophic EDL. Clenbuterol had no significant effect upon the slow twitch muscle soleus. |
PubMedSearch : Agbenyega_1995_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_111_397 |
PubMedID: 8564781 |
Agbenyega ET, Morton RH, Hatton PA, Wareham AC (1995)
Effect of the beta 2-adrenergic agonist clenbuterol on the growth of fast- and slow-twitch skeletal muscle of the dystrophic (C57BL6J dy2J\/dy2J) mouse
Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology
111 :397
Agbenyega ET, Morton RH, Hatton PA, Wareham AC (1995)
Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology
111 :397