Agrawal_2020_Food.Chem.Toxicol__111684

Reference

Title : Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway - Agrawal_2020_Food.Chem.Toxicol__111684
Author(s) : Agrawal M , Perumal Y , Bansal S , Arora S , Chopra K
Ref : Food & Chemical Toxicology , :111684 , 2020
Abstract :

In this study, the effect of Phycocyanin (Pc) to ameliorate the cognitive dysfunction in experimental model of Alzheimer's disease (AD) was evaluated. Intracerebroventricular (ICV) induction of Streptozotocin (STZ) (3 mg/kg) was done bilaterally twice in rats on alternative days. Rats were injected with Pc (50, 100 mg/kg; i.p.) for 28 days daily for behavioural and cholinergic activity assessment. As the effect was only significant at 100 mg/kg, later molecular experiments were performed using the same only. STZ induction led to increased activity of hippocampal cholinesterases and BAX and decreased activity of BCL-2 and ChAT. It enhanced TNF-alpha, and NF-kappaB in rat's brain and reduced BDNF and IGF-1 levels. Dysfunctional insulin signaling and decreased gene expressions of PI3-K, AKT was also observed. However, Pc treatment significantly prevented STZ-induced increased activity of hippocampal cholinesterases and BAX as well as increased the levels of BCL-2 and ChAT. Neuroinflammation was significantly attenuated and BDNF and IGF-1 levels were upregulated. Further, Pc also alleviated dysfunctional insulin signaling as evidenced by increased gene expression of IRS-1, PI3-K, AKT. In conclusion, our study demonstrated the immense potential of Pc in attenuating STZ-induced cognitive decline and it may be further explored as a therapeutic agent in managing AD.

PubMedSearch : Agrawal_2020_Food.Chem.Toxicol__111684
PubMedID: 32805344

Related information

Citations formats

Agrawal M, Perumal Y, Bansal S, Arora S, Chopra K (2020)
Phycocyanin alleviates ICV-STZ induced cognitive and molecular deficits via PI3-Kinase dependent pathway
Food & Chemical Toxicology :111684

Agrawal M, Perumal Y, Bansal S, Arora S, Chopra K (2020)
Food & Chemical Toxicology :111684