| Title : Three new cholinesterase-inhibiting cis-clerodane diterpenoids from Otostegia limbata - Ahmad_2005_Chem.Pharm.Bull.(Tokyo)_53_378 |
| Author(s) : Ahmad VU , Khan A , Farooq U , Kousar F , Khan SS , Nawaz SA , Abbasi MA , Choudhary MI |
| Ref : Chem Pharm Bull (Tokyo) , 53 :378 , 2005 |
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Abstract :
Three new tricyclic cis-clerodane type diterpenoids trivially named as limbatolide A (1), limbatolide B (2) and limbatolide C (3) have been isolated from the roots of Otostegia limbata along with two known compounds; oleanic acid and beta-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D) NMR techniques. Compounds 1-3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively. |
| PubMedSearch : Ahmad_2005_Chem.Pharm.Bull.(Tokyo)_53_378 |
| PubMedID: 15802835 |
| Inhibitor | Oleanolic-acid Ursolic-acid |
Ahmad VU, Khan A, Farooq U, Kousar F, Khan SS, Nawaz SA, Abbasi MA, Choudhary MI (2005)
Three new cholinesterase-inhibiting cis-clerodane diterpenoids from Otostegia limbata
Chem Pharm Bull (Tokyo)
53 :378
Ahmad VU, Khan A, Farooq U, Kousar F, Khan SS, Nawaz SA, Abbasi MA, Choudhary MI (2005)
Chem Pharm Bull (Tokyo)
53 :378