Ahmad_2021_Curr.Neuropharmacol__

BACKGROUND: Alzheimer's disease (AD) affecting several people worldwide and has devastating impacts in society with a limited number of approaches for its pharmacological treatment. The main causes of AD are not clear. However, the formation of senile plaques, neurofibrillary tangles, hyper-phosphorylation of tau protein, and disruption of redox homeostasis is the reason for AD. These causes have a positive correlation with oxidative stress, producing the reactive ions which are responsible for altering the physiological condition of the body. CONCLUSION: Ongoing research recommended the use of phytochemicals as acetylcholinesterase inhibitors to hinder AD onset and progression. The natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory, antioxidant, and anti-amyloidogenic properties. The purpose of this article is to provide a brief introduction to AD along with the use of natural compounds as new therapeutic approaches for its management.