Ahmed_2013_Indian.J.Clin.Biochem_28_381

Reference

Title : Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model? - Ahmed_2013_Indian.J.Clin.Biochem_28_381
Author(s) : Ahmed HH , Estefan SF , Mohamd EM , Farrag Ael R , Salah RS
Ref : Indian J Clinical Biochemistry , 28 :381 , 2013
Abstract :

This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl3 to induce AD and AD-induced rats treated with melatonin. Hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

PubMedSearch : Ahmed_2013_Indian.J.Clin.Biochem_28_381
PubMedID: 24426241

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Citations formats

Ahmed HH, Estefan SF, Mohamd EM, Farrag Ael R, Salah RS (2013)
Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model?
Indian J Clinical Biochemistry 28 :381

Ahmed HH, Estefan SF, Mohamd EM, Farrag Ael R, Salah RS (2013)
Indian J Clinical Biochemistry 28 :381