| Title : 1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation - Ahmed_2021_Pak.J.Pharm.Sci_34_855 |
| Author(s) : Ahmed A , Akhtar S , Mushtaq N , Haider S , Munawar R , Siddique HA , Akram A , Saify ZS , Arif M |
| Ref : Pak J Pharm Sci , 34 :855 , 2021 |
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Abstract :
Acetylcholine esterase (AChE) is a key biological target responsible for the management of cholinergic transmission, and its inhibitors are used for the therapy of Alzheimer's disease. In the present study, a small library of molecules with 1,3-di-4-piperidylpropane nucleus were docked on AChE. The selected compounds were synthesized and evaluated for their enzyme inhibition. P25 and P17 expressed significantly higher AChE inhibition than standards with IC50 values of 0.591microM and 0.625microM, respectively. Binding mode of derivatives in the active site of AChE revealed dual binding of molecules in peripheral anionic site (PAS) and catalytic anionic site (CAS) of enzyme cavity. |
| PubMedSearch : Ahmed_2021_Pak.J.Pharm.Sci_34_855 |
| PubMedID: 34602406 |
Ahmed A, Akhtar S, Mushtaq N, Haider S, Munawar R, Siddique HA, Akram A, Saify ZS, Arif M (2021)
1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation
Pak J Pharm Sci
34 :855
Ahmed A, Akhtar S, Mushtaq N, Haider S, Munawar R, Siddique HA, Akram A, Saify ZS, Arif M (2021)
Pak J Pharm Sci
34 :855