| Title : A new pancreatic lipase inhibitor from Broussonetia kanzinoki - Ahn_2012_Bioorg.Med.Chem.Lett_22_2760 |
| Author(s) : Ahn JH , Liu Q , Lee C , Ahn MJ , Yoo HS , Hwang BY , Lee MK |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :2760 , 2012 |
|
Abstract :
A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 muM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. |
| PubMedSearch : Ahn_2012_Bioorg.Med.Chem.Lett_22_2760 |
| PubMedID: 22450131 |
Ahn JH, Liu Q, Lee C, Ahn MJ, Yoo HS, Hwang BY, Lee MK (2012)
A new pancreatic lipase inhibitor from Broussonetia kanzinoki
Bioorganic & Medicinal Chemistry Lett
22 :2760
Ahn JH, Liu Q, Lee C, Ahn MJ, Yoo HS, Hwang BY, Lee MK (2012)
Bioorganic & Medicinal Chemistry Lett
22 :2760