Title : In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae (Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer's disease - Ajiboye_2018_Food.Sci.Nutr_6_1803 |
Author(s) : Ajiboye BO , Ojo OA , Okesola MA , Akinyemi AJ , Talabi JY , Idowu OT , Fadaka AO , Boligon AA , Anraku de Campos MM |
Ref : Food Sci Nutr , 6 :1803 , 2018 |
Abstract :
The phenolic extract of Senecio biafrae leaves was investigated to determine the in vitro antioxidant, phenolic profiles, and inhibition of key enzymes relevant to type II diabetes mellitus (alpha-amylase and alpha-glucosidase) and Alzheimer's disease (acetylcholinesterase and butrylcholinesterase). The phenolic extract demonstrated significant scavenging abilities against all in vitro antioxidant parameters assessed. Reversed-phase HPLC of the extract revealed the presence of gallic acid, chlorogenic, caffeic acid, rutin, quercetin, and kaempferol. The extract also inhibited activities of alpha-amylase (IC 50 = 126.90 mug/ml), alpha-glucosidase (IC 50 = 139.66 mug/ml), acetylcholinesterase (IC 50 = 347.22 mug/ml), and butrylcholinesterase (IC 50 = 378.79 mug/ml), which may be attributed to the antioxidant potential of the extract and its phenolic composition. Therefore, this study suggests that the leaves of S. biafrae may be useful in the management of diabetes mellitus and Alzheimer's disease. |
PubMedSearch : Ajiboye_2018_Food.Sci.Nutr_6_1803 |
PubMedID: 30349669 |
Ajiboye BO, Ojo OA, Okesola MA, Akinyemi AJ, Talabi JY, Idowu OT, Fadaka AO, Boligon AA, Anraku de Campos MM (2018)
In vitro antioxidant activities and inhibitory effects of phenolic extract of Senecio biafrae (Oliv and Hiern) against key enzymes linked with type II diabetes mellitus and Alzheimer's disease
Food Sci Nutr
6 :1803
Ajiboye BO, Ojo OA, Okesola MA, Akinyemi AJ, Talabi JY, Idowu OT, Fadaka AO, Boligon AA, Anraku de Campos MM (2018)
Food Sci Nutr
6 :1803