Title : Subchronic exposure to leachate activates key markers linked with neurological disorder in Wistar male rat - Akintunde_2015_Environ.Sci.Pollut.Res.Int_22_18541 |
Author(s) : Akintunde JK , Oboh G |
Ref : Environ Sci Pollut Res Int , 22 :18541 , 2015 |
Abstract :
The linking of various environmental chemicals exposure to neurodegenerative disorders is current. This study was undertaken to elucidate the toxic effects and the underlying biochemical mechanism of leachate obtained from Elewi Odo municipal battery recycling site (EOMABRL) using key markers of neuronal damage in rat via an oral route. Analysis of the concentrations of heavy metals showed that lead, cadmium, nickel, chromium, manganese, and iron were higher than the acceptable limits set by the regulatory authority-the World Health Organization. Whereas, copper, zinc, and cobalt were lower than permissible limits. EOMABRL was administered at 0, 20, 40, 60, 80, and 100 % concentrations to adult male rats for 60 days. An in vitro study was also carried out in the cerebellum to assess cholinesterase biochemistry assays. Following exposure, brain was collected to determine the antioxidant status. EOMABRL administration significantly increased superoxide dismutase (SOD) and catalase (CAT) activities, and a sequential decrease in reduced glutathione (GSH) level with a concomitant increase in the accumulation of hydrogen peroxide (H2O2) and malondialdehyde (MDA) level was observed, when compared with the control. The treated rat had a significant (P < 0.05) increase in the activities of acetycholinesterase (AChE) and butyrylcholinesterase (BuChE). Taken together, these findings conclude that some possible mechanisms by which EOMABRL elicits neuronal disorder in male rat could be through the activation of AChE and BuChE and induction of oxidative stress with necrosis of neuronal cells. |
PubMedSearch : Akintunde_2015_Environ.Sci.Pollut.Res.Int_22_18541 |
PubMedID: 26362636 |
Akintunde JK, Oboh G (2015)
Subchronic exposure to leachate activates key markers linked with neurological disorder in Wistar male rat
Environ Sci Pollut Res Int
22 :18541
Akintunde JK, Oboh G (2015)
Environ Sci Pollut Res Int
22 :18541