Aksu_2015_Arch.Pharm.(Weinheim)_348_446

The antioxidant and acetylcholinesterase inhibitory properties of novel symmetric sulfamides derived from phenethylamines were evaluated. Phenethylamines 8-11 were reacted with SO2 Cl2 in the presence of Et3 N to afford sulfamides in good yields. The synthesized sulfamides were converted to their phenolic derivatives with BBr3 . We elucidated the antioxidant activity of novel symmetric sulfamides by using different bioanalytical assays. For this purpose, the radical scavenging activities of the novel symmetric sulfamides were assessed by DPPH(*) , ABTS(*+) , DMPD(*+) , and O2 (*-) radical scavenging tests. In addition, the reducing abilities of the novel symmetric sulfamides were evaluated by Fe(3+) -Fe(2+) reducing, Cu(2+) -Cu(+) reducing, and [Fe(3+) -(TPTZ)2 ](3+) -[Fe(2+) -(TPTZ)2 ](2+) reducing activity tests. Also, the Fe(2+) chelating activity by the pipyrdyl reagent and the acetylcholinesterase inhibitory activities of the novel symmetric sulfamides were studied. Especially, the novel phenolic and symmetric sulfamides 16-19 showed high antioxidant and acetylcholinesterase inhibitory properties. On the other hand, IC50 values were calculated for the DPPH(*) , ABTS(*+) , DMPD(*+) , and O2 (*-) scavenging, the metal chelating, and the acetylcholinesterase inhibition effects of the novel symmetric sulfamides.