| Title : Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites - Al-Aboudi_2009_J.Enzyme.Inhib.Med.Chem_24_553 |
| Author(s) : Al-Aboudi A , Odeh H , Khalid A , Naz Q , Choudhary MI |
| Ref : J Enzyme Inhib Med Chem , 24 :553 , 2009 |
|
Abstract :
Testosterone and ten of its metabolites were examined as inhibitors of butyrylcholinesterase. A significant enzyme inhibition activity (IC(50) = 1.55 microM) was observed for androst-4-en-3,7-dione. The kinetic parameters of butyrylcholinesterase inhibition were determined and molecular docking was carried out in order to develop a better understanding of the inhibitor-enzyme interactions. The results showed that the inhibition was non-competitive, stabilized mainly by hydrogen bonds and hydrophobic interactions between the inhibitor and butyrylcholinesterase. |
| PubMedSearch : Al-Aboudi_2009_J.Enzyme.Inhib.Med.Chem_24_553 |
| PubMedID: 18728994 |
Al-Aboudi A, Odeh H, Khalid A, Naz Q, Choudhary MI (2009)
Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites
J Enzyme Inhib Med Chem
24 :553
Al-Aboudi A, Odeh H, Khalid A, Naz Q, Choudhary MI (2009)
J Enzyme Inhib Med Chem
24 :553