Al-Rashid_2011_Bioorg.Med.Chem.Lett_21_2687

Reference

Title : (+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase - Al-Rashid_2011_Bioorg.Med.Chem.Lett_21_2687
Author(s) : Al-Rashid ZF , Hsung RP
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2687 , 2011
Abstract :

A computation docking study of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. The model suggests that (+)-arisugacin A is a dual binding site covalent inhibitor of AChE. These findings are examined in the context of Alzheimer's disease-modifying therapeutic design. (+)-Arisugacin A's revealed mode of action is unique, and may serve as a basis for the development of AD therapeutics capable of treating the symptomatic aspects of AD, while being neuroprotective with long term efficacy.

PubMedSearch : Al-Rashid_2011_Bioorg.Med.Chem.Lett_21_2687
PubMedID: 21216144

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Citations formats

Al-Rashid ZF, Hsung RP (2011)
(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 21 :2687

Al-Rashid ZF, Hsung RP (2011)
Bioorganic & Medicinal Chemistry Lett 21 :2687