| Title : Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels - AlGhamdi_2023_R.Soc.Open.Sci_10_230013 |
| Author(s) : AlGhamdi SA , Al-Abbasi FA , Alghamdi AM , Omer AB , Afzal O , Altamimi ASA , Alamri A , Alzarea SI , Almalki WH , Kazmi I |
| Ref : R Soc Open Sci , 10 :230013 , 2023 |
|
Abstract :
The current study was designed for the evaluation of barbigerone on memory loss. In this experimental study, 24 Wistar rats (n = 6) were used. Control rats and scopolamine (SCOP)-treated control group rats were orally administered with 3 ml of 0.5% sodium carboxymethyl cellulose (vehicle), whereas barbigerone was (10 and 20 mg kg(-1)) administered orally to the rats from the test group. During the 14-day treatment, control group rats were given 3 ml kg(-1) day(-1) saline, and all other groups were administered SCOP (1 mg kg(-1) day(-1), i.p.) 1 h after barbigerone p.o. treatment. The spontaneous alternation activities, learning capacities of a rat's memory were tested with Morris water maze and Y-maze. Reduced glutathione, malondialdehyde, acetylcholine esterase (AChE) and catalase (CAT) levels were measured in rat brain tissue as oxidative stress/antioxidant markers. Moreover, the levels of tumour necrosis factor, interleukin-6 (IL-6) and IL-1beta were also estimated. Treatment with barbigerone in SCOP-administered rats dramatically reduced SCOP-induced neurobehavioural deficits, oxidative stress and neuroinflammatory markers, improved endogenous antioxidants, and restored AChE activity. By improving cholinergic function and reducing oxidative damage, barbigerone could mitigate the effects of SCOP-induced changes in the brain. |
| PubMedSearch : AlGhamdi_2023_R.Soc.Open.Sci_10_230013 |
| PubMedID: 37063992 |
AlGhamdi SA, Al-Abbasi FA, Alghamdi AM, Omer AB, Afzal O, Altamimi ASA, Alamri A, Alzarea SI, Almalki WH, Kazmi I (2023)
Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels
R Soc Open Sci
10 :230013
AlGhamdi SA, Al-Abbasi FA, Alghamdi AM, Omer AB, Afzal O, Altamimi ASA, Alamri A, Alzarea SI, Almalki WH, Kazmi I (2023)
R Soc Open Sci
10 :230013