Albayrak_2022_Chem.Biodivers__

In this study, the anticholinesterase effects of the extracts and isolated compounds from the roots of endemic Prangos uechtritzii Boiss & Hausskn (Apiaceae) are reported. A novel polyacetylenic compound; (+)-8-O-methyloplopantriol A along with two known polyacetylenes; (-)-panaxynol, (+)-falcarindiol and fifteen known coumarin derivatives; umbelliferone, 6-formylumbelliferone, suberosin, 7-demethylsuberosin, (+)-ulopterol, tamarin, psoralen, imperatorin, (+)-oxypeucedanin, (+)-oxypeucedanin hydrate, (+)-oxypeucedanin methanolate, (+)-marmesin, (-)-prantschimgin, (+)-decursinol and (-)-adicardin were isolated from the n -hexane (Pu-HE), chloroform (Pu-CE), methanol (Pu-ME) extracts of P. uechtritzii roots. (-)-Panaxynol , (+)-falcarindiol , 6-formylumbelliferone , (+)-decursinol and (-)-adicardin were obtained from the genus Prangos for the first time. (+)-8-O-methyloplopantriol A inhibited both AChE (IC 50 = 194.5+/-5.8 microM) and BChE (IC 50 = 51.9+/-2.96 microM) enzymes. (+)-Falcarindiol, 6-formylumbelliferone, 7-demethylsuberosin, tamarin, and imperatorin also exhibited BChE specific inhibitory activities (IC 50 = 27.88-93.86 microM). (+)-Falcarindiol (IC 50 = 27.88+/-0.91 microM) and imperatorin (IC 50 = 30.89+/-1.40 microM) as the most active components could be lead compounds to develop new BChE inhibitors with further research against Alzheimer's Disease.