Albuquerque_1978_Science_199_788

Reference

Title : Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor - Albuquerque_1978_Science_199_788
Author(s) : Albuquerque EX , Eldefrawi AT , Eldefrawi ME , Mansour NA , Tsai MC
Ref : Science , 199 :788 , 1978
Abstract :

Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.

PubMedSearch : Albuquerque_1978_Science_199_788
PubMedID: 622570

Related information

Citations formats

Albuquerque EX, Eldefrawi AT, Eldefrawi ME, Mansour NA, Tsai MC (1978)
Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor
Science 199 :788

Albuquerque EX, Eldefrawi AT, Eldefrawi ME, Mansour NA, Tsai MC (1978)
Science 199 :788