| Title : Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N-Methylation in Omphalotin Biosynthesis - Aldemir_2017_Angew.Chem.Int.Ed.Engl_56_13570 |
| Author(s) : Aldemir H , Gulder TAM |
| Ref : Angew Chem Int Ed Engl , 56 :13570 , 2017 |
|
Abstract :
Tail-Me: The N-methylation of backbone amide bonds in peptide natural products was thought to be exclusive to non-ribosomal peptides. A newly discovered methylation mechanism now brings this structural feature into the world of ribosomal peptides, thereby significantly expanding the structural diversity of ribosomally synthesized and post-translationally modified peptides (RiPPs). |
| PubMedSearch : Aldemir_2017_Angew.Chem.Int.Ed.Engl_56_13570 |
| PubMedID: 28949431 |
| Substrate | Omphalotin-A |
Aldemir H, Gulder TAM (2017)
Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N-Methylation in Omphalotin Biosynthesis
Angew Chem Int Ed Engl
56 :13570
Aldemir H, Gulder TAM (2017)
Angew Chem Int Ed Engl
56 :13570