Title : Somatostatin and cognitive functions in Alzheimer's disease--the relationship of cerebrospinal fluid somatostatin increase with clinical response to tetrahydroaminoacridine - Alhainen_1991_Neurosci.Lett_130_46 |
Author(s) : Alhainen K , Sirvio J , Helkala EL , Reinikainen K , Riekkinen P, Sr. |
Ref : Neuroscience Letters , 130 :46 , 1991 |
Abstract :
We studied the effect of tetrahydroaminoacridine (THA) on cerebrospinal fluid somatostatin-like immunoreactivity (CSF-SLI) in probable Alzheimer disease (AD) patients (n = 20) who took part in an open THA treatment trial. The maintenance dose (100 mg/day) was continued for 4 weeks. Samples of CSF were obtained before treatment and at the end of the treatment period. The CSF-SLI increased significantly (P = 0.01) in the responders for the treatment (increase of the Mini-Mental State Examination score greater than or equal to 3; n = 11), while the non-responders (n = 9) showed a significant decrease of CSF-SLI (P = 0.003). The change of CSF-SLI had also a significant correlation (P = 0.001) with neuropsychological performance. We conclude that the effects of of THA on the CSF-SLI may be due to presynaptic cholinergic or direct somatostatinergic stimulation. |
PubMedSearch : Alhainen_1991_Neurosci.Lett_130_46 |
PubMedID: 1684233 |
Alhainen K, Sirvio J, Helkala EL, Reinikainen K, Riekkinen P, Sr. (1991)
Somatostatin and cognitive functions in Alzheimer's disease--the relationship of cerebrospinal fluid somatostatin increase with clinical response to tetrahydroaminoacridine
Neuroscience Letters
130 :46
Alhainen K, Sirvio J, Helkala EL, Reinikainen K, Riekkinen P, Sr. (1991)
Neuroscience Letters
130 :46