Title : Rosinidin Protects Streptozotocin-Induced Memory Impairment-Activated Neurotoxicity by Suppressing Oxidative Stress and Inflammatory Mediators in Rats - Alharbi_2022_Medicina.(Kaunas)_58_ |
Author(s) : Alharbi KS , Afzal M , Alzarea SI , Khan SA , Alomar FA , Kazmi I |
Ref : Medicina (Kaunas) , 58 : , 2022 |
Abstract :
Background and Objectives: To assess the antioxidant and neuroprotective role of rosinidin on rat memory impairment that is induced by streptozotocin. Materials and Methods: Wistar rats were given an intraperitoneal (i.p) injection of streptozotocin (60 mg/kg) followed by treatment with rosinidin at selective doses (10 and 20 mg/kg) for 30 days. The behavioral parameters were estimated by Y-maze test and Morris water test. Biochemical parameters such as acetylcholinesterase (AChE), choline aacetyltransferase (ChAT), and nitric oxide, and antioxidants such as glutathione transferase (GSH), superoxide dismutase (SOD) IL-6, IL-10, Nrf2, and BDNF, were determined. Results: The study results revealed that rosinidin improved cognition by reverting the behavioral parameters. The treatment with rosinidin restored the antioxidant enzymes and inflammatory cytokines. Conclusions: From the results, it has been proven that rosinidin possesses antioxidant, anti-amnesic, and anti-inflammatory activity. Rosinidin improved the cognitive and behavioral deficits that were induced by streptozotocin. Furthermore, 20 mg/kg rosinidin was found to have strong protective action against streptozotocin-induced toxicity. |
PubMedSearch : Alharbi_2022_Medicina.(Kaunas)_58_ |
PubMedID: 35893108 |
Alharbi KS, Afzal M, Alzarea SI, Khan SA, Alomar FA, Kazmi I (2022)
Rosinidin Protects Streptozotocin-Induced Memory Impairment-Activated Neurotoxicity by Suppressing Oxidative Stress and Inflammatory Mediators in Rats
Medicina (Kaunas)
58 :
Alharbi KS, Afzal M, Alzarea SI, Khan SA, Alomar FA, Kazmi I (2022)
Medicina (Kaunas)
58 :