| Title : Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead - Alkondon_1990_FEBS.Lett_261_124 |
| Author(s) : Alkondon M , Costa AC , Radhakrishnan V , Aronstam RS , Albuquerque EX |
| Ref : FEBS Letters , 261 :124 , 1990 |
|
Abstract :
The effect of Pb2+ on glutamate receptor activity in rat hippocampal neurons was investigated with a view of explaining the cognitive and learning deficits produced by this heavy metal. Pb2+ (2.5-50 microM) selectively inhibited N-methyl-D-aspartate (NMDA)-induced whole-cell and single-channel currents in a concentration-dependent but voltage-independent manner, without significantly altering currents induced by either quisqualate or kainate. The frequency of NMDA-induced channel activation was decreased by Pb2+. Neither glycine (10-100 microM), nor Ca2+ (10 mM) reversed the effect of Pb2+. Pb2+ also inhibited the [3H]MK-801 binding to rat hippocampal membranes in vitro. The elucidation of the actions of Pb2+ on the NMDA receptor ion channel complex provides important insights into the clinical and toxic effects of this cation. |
| PubMedSearch : Alkondon_1990_FEBS.Lett_261_124 |
| PubMedID: 1689669 |
Alkondon M, Costa AC, Radhakrishnan V, Aronstam RS, Albuquerque EX (1990)
Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead
FEBS Letters
261 :124
Alkondon M, Costa AC, Radhakrishnan V, Aronstam RS, Albuquerque EX (1990)
FEBS Letters
261 :124