| Title : Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors - Alpan_2013_Bioorg.Med.Chem_21_4928 |
| Author(s) : Alpan AS , Parlar S , Carlino L , Tarikogullari AH , Alptuzun V , Gunes HS |
| Ref : Bioorganic & Medicinal Chemistry , 21 :4928 , 2013 |
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Abstract :
A series of N-{2-[4-(1H-benzimidazole-2-yl)phenoxy]ethyl}substituted amine derivatives were designed to assess cholinesterase inhibitor activities. Acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) inhibitor activities were evaluated in vitro by using Ellman's method. It was discovered that most of the compounds displayed AChE and/or BCHE inhibitor activity and few compounds were selective against AChE/BCHE. Compound 3c and 3e were the most active compounds in the series against eeAChE and hAChE, respectively. Molecular docking studies and molecular dynamics simulations were also carried out. |
| PubMedSearch : Alpan_2013_Bioorg.Med.Chem_21_4928 |
| PubMedID: 23891231 |
Alpan AS, Parlar S, Carlino L, Tarikogullari AH, Alptuzun V, Gunes HS (2013)
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry
21 :4928
Alpan AS, Parlar S, Carlino L, Tarikogullari AH, Alptuzun V, Gunes HS (2013)
Bioorganic & Medicinal Chemistry
21 :4928