| Title : Synthesis and Biological Evaluation of New Tacrine Analogues under Microwave Irradiation - Alshareef_2017_Chem.Pharm.Bull.(Tokyo)_65_732 |
| Author(s) : Alshareef HF , Mohamed H , Salaheldin AM |
| Ref : Chem Pharm Bull (Tokyo) , 65 :732 , 2017 |
|
Abstract :
Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe-Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedlander reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman's test on acetylcholinesterase inhibition. |
| PubMedSearch : Alshareef_2017_Chem.Pharm.Bull.(Tokyo)_65_732 |
| PubMedID: 28768927 |
Alshareef HF, Mohamed H, Salaheldin AM (2017)
Synthesis and Biological Evaluation of New Tacrine Analogues under Microwave Irradiation
Chem Pharm Bull (Tokyo)
65 :732
Alshareef HF, Mohamed H, Salaheldin AM (2017)
Chem Pharm Bull (Tokyo)
65 :732