| Title : Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme - Andrade_2005_Bioorg.Med.Chem_13_4092 |
| Author(s) : Andrade MT , Lima JA , Pinto AC , Rezende CM , Carvalho MP , Epifanio RA |
| Ref : Bioorganic & Medicinal Chemistry , 13 :4092 , 2005 |
|
Abstract :
Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis (Muell. Arg) Miers were tentatively identified by GC-MS, viz., coronaridine (1), voacangine (2), voacangine hydroxyindolenine (3), rupicoline (4), ibogamine (5), ibogaine (6), ibogaline (7), desethyl-voacangine (8), voachalotine (9), and affinisine (10). Of these, the first four were isolated by silica gel open column chromatography, identified by uni- and bidimensional NMR, IR, MS and showed anti-cholinesterasic activity at the same concentration as the reference compounds physostigmine and galanthamine (detection limit of 0.01mM) by TLC assay using the modified Ellman's method. |
| PubMedSearch : Andrade_2005_Bioorg.Med.Chem_13_4092 |
| PubMedID: 15911323 |
| Substrate | Voacangine |
Andrade MT, Lima JA, Pinto AC, Rezende CM, Carvalho MP, Epifanio RA (2005)
Indole alkaloids from Tabernaemontana australis (Muell. Arg) Miers that inhibit acetylcholinesterase enzyme
Bioorganic & Medicinal Chemistry
13 :4092
Andrade MT, Lima JA, Pinto AC, Rezende CM, Carvalho MP, Epifanio RA (2005)
Bioorganic & Medicinal Chemistry
13 :4092