| Title : Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1-b]thiazole derivatives - Andreani_2005_Eur.J.Med.Chem_40_1331 |
| Author(s) : Andreani A , Granaiola M , Guardigli M , Leoni A , Locatelli A , Morigi R , Rambaldi M , Roda A |
| Ref : Eur Journal of Medicinal Chemistry , 40 :1331 , 2005 |
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Abstract :
The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as acetylcholinesterase inhibitors by means of a chemiluminescent method suitable for high throughput screening. The compounds without quaternization had no appreciable inhibitory potency probably because they are poorly soluble in water. The corresponding quaternized compounds were good inhibitors with activity related to the spacer employed. |
| PubMedSearch : Andreani_2005_Eur.J.Med.Chem_40_1331 |
| PubMedID: 16129518 |
Andreani A, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Roda A (2005)
Synthesis and chemiluminescent high throughput screening for inhibition of acetylcholinesterase activity by imidazo[2,1-b]thiazole derivatives
Eur Journal of Medicinal Chemistry
40 :1331
Andreani A, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Roda A (2005)
Eur Journal of Medicinal Chemistry
40 :1331